The Value of Radiotherapy in the Oligometastatic Non-squamous Non-small Cell Lung Cancer With Clinical Benefits From Erlotinib as Second-line Treatment

NCT01796288 | Unknown Phase 2 DMC

• 1 other identifier: 1209114-5
• Study Type: interventional
• Target: 200
• Locations: 1 country
• Sites: 1

Brief Summary

This was a multi-center randomized controlled Phase II clinical trial. Patients with oligometastatic stage IV (number of distant metastases ≤ 5) non-squamous non-small cell lung cancer treated with second-line erlotinib150mg daily for 3 months with clinical benefits (free-from progression) were randomized (stratified according to smoking status and different research centers) to the radiotherapy group (n = 100) and the non-radiotherapy group (n = 100). Radiotherapy group (experimental group) patients started simultaneously radiotherapy for all gross tumors soon after randomization; non-radiotherapy group (control group) received no radiotherapy for all gross tumors. Erlotinib was continuously used until to disease progression or unbearable adverse effect, and the subsequently further salvage therapies were determined by the investigators. The primary endpoint was PFS.

Conditions

Non Small Cell Lung Cancer, Oligometastatic

Keywords

NSCLC; oligometastatic; second-line; Radiotherapy; Erlotinib

Outcome Measures

Primary Outcomes (1)

• progession-free survival

  3.5 year

Secondary Outcomes (1)

• overall survival

  5 year

Study Arms (2)

Erlotinib & simultaneous radiotherapy

EXPERIMENTAL

patients started simultaneously radiotherapy for all gross tumors

Radiation: simultaneous radiotherapy; Drug: Erlotinib

Erlotinib & no radiotherapy

OTHER

patients received no radiotherapy for all gross tumors

Drug: Erlotinib

Interventions

simultaneous radiotherapy RADIATION

Erlotinib & simultaneous radiotherapy

Erlotinib DRUG

Erlotinib & no radiotherapy; Erlotinib & simultaneous radiotherapy

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Has signed informed consent;
• Male or female aged 18 years or older;
• Histologically or cytologically identified non-squamous non-small cell lung cancer;
• PS score 0-2;
• Stage IV patients with distant metastasis (according to the latest AJCC/UICC lung cancer staging, upper neck lymph nodes belonging to distant metastases; ipsilateral/contralateral mediastinal lymph nodes, supraclavicular and lower neck lymph nodes belonging to local regional areas and are not included in distant metastases), who occurred disease progression after receiving a course of systemic chemotherapy, or who hadn't complete the planned course of the first-line chemotherapy but they were intolerance or refused to continue treatment;
• Received second-line erlotinib treatment;
• The patients who taking erlotinib for 3 months then the efficacy evaluation found clinical benefits (CR+PR+SD);
• Metastatic NSCLC with distant metastases number ≤ 5 (for metastases in the same organ, the number counted as the separate metastatic focus) and the longest diameter of each metastatic foci on CT should \> 1cm, but brain (including the parenchyma and meninges) metastasis, malignant pleural/pericardial effusion, or abdominal effusion were not allowed;
• Have never received local treatment, including surgery, radiation therapy, and radiofrequency ablation for primary and distant metastases;
• Patients must received systemic PET-CT examination before treatment with erlotinib, to more accurately identify the status of patients with distant metastases;
• The diagnosis of bone and liver metastases:
• On the basis of clinical symptoms, an imaging support was necessary for the clinical diagnosis of bone metastases; if the clinical symptoms were absent, two imaging supports of bone metastases were necessary for the clinical diagnosis of bone metastasis; adjacent bone metastases (such as the two adjacent vertebral metastases) was considered to be a single metastasis.
• MRI or enhanced CT confirmations were needed for liver metastases diagnosis;
• Have never received other targeted drug treatments for EGFR inhibition;
• If metastases in a same organ ≤ 4 and the amount of metastatic focus ≤ 5, it should be determined by the radiation therapists in the research group to judge if the patients can tolerate all positive focus (including primary and metastatic focus) receiving radiotherapy, the radiotherapy dose should be selected by treating physician according to the patients' conditions from several regimens including conventional split curative doses or palliative doses, and hypofractionated radiotherapy (for details please refer to the radiation therapy section);

You may not qualify if:

• The pathological type was squamous cell carcinoma, or mixed with small cell components in non-small cell lung cancer;
• With brain metastasis regardless of parenchymal or meningeal metastasis;
• Malignant pleural effusion, pericardial effusion or peritoneal effusion;
• The longest diameter of metastatic focus on CT were \<1cm, or the amount of metastatic focus \> 5;
• Metastases appeared within a same organ simultaneously;
• The efficacy evaluation after erlotinib treatment for 3 months showed PD (progression of disease);
• Local treatment had been used for the primary and distant metastatic focus;
• Radiation therapists thought that the patient couldn't tolerate/receive radiotherapy for all the focus;
• Has previously suffered from interstitial lung disease, drug-induced interstitial lung disease, or any active interstitial lung disease with clinical evidences;
• Chest CT found idiopathic pulmonary fibrosis;
• Patients with multiple pulmonary bullae, chronic lung disease, or acute lung infection;
• With any chronic toxicity induced by previous anti-cancer treatment, it was undimunished and higher than CTCAE level 2;
• Diagnosed or accompanied by any other malignant disease (except basal cell carcinoma or cervical carcinoma in situ) over the past five years;
• According to the judgments of the investigators, there was any serious or uncontrolled systemic disease (e.g. heart, liver, or kidney disease) or active infection;
• Combined use with phenytoin, carbamazepine, rifampicin, phenobarbital, or St. John's wort;

Sponsors & Collaborators

• Wu Jieping Medical Foundation: lead
• Shanghai Chest Hospital: collaborator
• Shanghai Pulmonary Hospital, Shanghai, China: collaborator
• Fudan University: collaborator
• Zhejiang Cancer Hospital: collaborator
• Anhui Provincial Hospital: collaborator
• Anhui Medical University: collaborator
• Wuxi No. 4 People's Hospital: collaborator

Study Sites (1)

Fudan University Shanghai Cancer Center

Shanghai, Shanghai Municipality, 200032, China

RECRUITING

MeSH Terms

Conditions

Carcinoma, Non-Small-Cell Lung

Interventions

Erlotinib Hydrochloride

Condition Hierarchy (Ancestors)

Carcinoma, Bronchogenic; Bronchial Neoplasms; Lung Neoplasms; Respiratory Tract Neoplasms; Thoracic Neoplasms; Neoplasms by Site; Neoplasms; Lung Diseases; Respiratory Tract Diseases

Intervention Hierarchy (Ancestors)

Quinazolines; Heterocyclic Compounds, 2-Ring; Heterocyclic Compounds, Fused-Ring; Heterocyclic Compounds

Central Study Contacts

Xiaolong Fu, ph.D&MD

CONTACT

xlfu1964@126.com

Study Design

• Study Type: interventional
• Phase: phase 2
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Fudan University Shanghai Cancer Center

Study Record Dates

• First Submitted: February 18, 2013
• First Posted: February 21, 2013
• Study Start: October 1, 2012
• Primary Completion: April 1, 2016
• Study Completion: October 1, 2017
• Last Updated: February 21, 2013

Record last verified: 2012-10

Locations

CN (1)