Assessment of Atrial Tissue Obtained From Patients Undergoing Heart Surgery and Tissue Banking
1 other identifier
observational
37
1 country
1
Brief Summary
Over the past decade, techniques have been refined which permit an enormous amount of information relevant to disease mechanisms to be gained from the examination of heart tissue. The Cardiovascular Institute has extensive experience with these techniques, and has utilized them to examine other heart disease substrates. In this study, the investigators propose to obtain heart tissue at the time of cardiac surgery which would otherwise be discarded. Their plan is to examine this tissue and correlate their findings with clinical data. Their hope is that the proposed study will provide insight into atrial physiology, including the molecular mechanisms underlying atrial disease and the potential development of atrial fibrillation (AF).
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for all trials
Started Dec 2012
Typical duration for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
December 11, 2012
CompletedFirst Submitted
Initial submission to the registry
January 17, 2013
CompletedFirst Posted
Study publicly available on registry
February 15, 2013
CompletedPrimary Completion
Last participant's last visit for primary outcome
February 17, 2016
CompletedStudy Completion
Last participant's last visit for all outcomes
February 17, 2016
CompletedMarch 22, 2023
March 1, 2023
3.2 years
January 17, 2013
March 20, 2023
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Evidence of atrial physiology
Normally discarded atrial tissue samples will be collected at the time of cardiac surgery and microscopic histology will be performed using standard tissue stains
Visit 1, Atrial tissue sample obtained at the time of surgery
Secondary Outcomes (1)
Evidence of underlying molecular mechanisms of atrial disease
Visit 1, Atrial tissue samples obtained at the time of surgery
Study Arms (1)
nonemergent heart surgery, atrial tissue
patients undergoing non-emergent heart surgery
Interventions
Eligibility Criteria
Subjects are patients of UPMC Cardiothoracic Surgery who are having standard of care open heart surgery
You may qualify if:
- years or over
- Referred for heart surgery for standard indication
- Competent to give informed consent
You may not qualify if:
- Inability to give informed consent
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
University Pittsburgh Medical Center
Pittsburgh, Pennsylvania, 15213, United States
Related Publications (1)
Li YY, Feldman AM, Sun Y, McTiernan CF. Differential expression of tissue inhibitors of metalloproteinases in the failing human heart. Circulation. 1998 Oct 27;98(17):1728-34. doi: 10.1161/01.cir.98.17.1728.
PMID: 9788826BACKGROUND
Biospecimen
(1) myocardial tissue (2) DNA
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Yingze Zhang, PhD
University of Pittsburgh
Study Design
- Study Type
- observational
- Observational Model
- CASE ONLY
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Professor of Medicine and Human Genetics
Study Record Dates
First Submitted
January 17, 2013
First Posted
February 15, 2013
Study Start
December 11, 2012
Primary Completion
February 17, 2016
Study Completion
February 17, 2016
Last Updated
March 22, 2023
Record last verified: 2023-03