The Effect of Bovine Colostrum Supplementation in Older Adults

NCT01792297 | Completed

• 1 other identifier: 12-255
• Study Type: interventional
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

Bovine colostrum is the initial milk secreted by cows during the first day after calving. Colostrum is high in protein and contains a number of substances that have potential to be beneficial for the immune system. Preliminary studies about effects of colostrum supplementation show its potential for increasing human exercise performance; however, more evidence across the lifespan is required to confirm effects and to understand mechanisms of action. The objectives are to determine the effect of 8 weeks of bovine colostrum supplementation, compared to whey protein supplementation on the following dependent variables in men and women 50 years and older while participating in a resistance-training program:

• muscle mass
• strength
• blood levels of growth factors and markers of inflammation
• urine levels of muscle and bone catabolic markers
• tests of cognitive ability It is hypothesized that bovine colostrum supplementation will result in greater increases in muscle mass, strength, blood IGF-1 levels (an anabolic hormone), and cognitive ability, and greater reductions in inflammation, and markers of muscle and bone catabolism, compared to placebo.

Conditions

Sarcopenia; Osteoporosis

Keywords

Sarcopenia; Osteoporosis; Cognition; Inflammation

Outcome Measures

Primary Outcomes (3)

• change from baseline in lean tissue mass at 8 weeks

  Lean tissue mass assessed by dual energy x-ray absorptiometry

  baseline and 8 weeks

• Change from baseline in Upper body strength at 8 weeks

  Bench Press Strength

  baseline and 8 weeks

• Change from baseline in Lower body strength at 8 weeks

  Leg press strength

  baseline and 8 weeks

Secondary Outcomes (8)

• Change from baseline in Insulin like growth factor-1 at 8 weeks

  baseline and 8 weeks

• Change from baseline in upper body muscle thickness at 8 weeks

  baseline and 8 weeks

• Change from baseline in lower body muscle thickness at 8 weeks

  baseline and 8 weeks

• Change from baseline in muscle catabolism at 8 weeks

  baseline and 8 weeks

• Change from baseline in bone catabolism at 8 weeks

  Baseline and 8 weeks

Study Arms (2)

Bovine Colostrum

EXPERIMENTAL

60 g/d bovine colostrum in powder form to be mixed with drinks. The dose will be spread out 3 times per day (20 g per dose)

Dietary Supplement: Bovine colostrum

Whey protein

ACTIVE COMPARATOR

60 g/d whey protein powder mixed into drinks. It is to be divided into 3 daily doses (20 g per dose)

Dietary Supplement: Whey protein

Interventions

Bovine colostrum DIETARY_SUPPLEMENT

Bovine Colostrum

Whey protein DIETARY_SUPPLEMENT

Whey protein

Eligibility Criteria

• Age: 50 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Men or women 50 y or older

You may not qualify if:

• Milk allergies
• Contraindications to exercise as indicated by the Physical Activity Readiness Questionnaire

Sponsors & Collaborators

• University of Saskatchewan: lead
• Mitacs: collaborator

Study Sites (1)

College of Kinesiology, University of Saskatchewan

Saskatoon, Saskatchewan, S7N 5B2, Canada

Location

Related Publications (2)

• Antonio J, Sanders MS, Van Gammeren D. The effects of bovine colostrum supplementation on body composition and exercise performance in active men and women. Nutrition. 2001 Mar;17(3):243-7. doi: 10.1016/s0899-9007(00)00552-9.

  PMID: 11312068 BACKGROUND

• Kerksick CM, Rasmussen C, Lancaster S, Starks M, Smith P, Melton C, Greenwood M, Almada A, Kreider R. Impact of differing protein sources and a creatine containing nutritional formula after 12 weeks of resistance training. Nutrition. 2007 Sep;23(9):647-56. doi: 10.1016/j.nut.2007.06.015.

  PMID: 17679046 BACKGROUND

MeSH Terms

Conditions

Sarcopenia; Osteoporosis; Inflammation

Interventions

Whey Proteins

Condition Hierarchy (Ancestors)

Muscular Atrophy; Neuromuscular Manifestations; Neurologic Manifestations; Nervous System Diseases; Atrophy; Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms; Signs and Symptoms; Bone Diseases, Metabolic; Bone Diseases; Musculoskeletal Diseases; Metabolic Diseases; Nutritional and Metabolic Diseases; Pathologic Processes

Intervention Hierarchy (Ancestors)

Milk Proteins; Animal Proteins, Dietary; Dietary Proteins; Proteins; Amino Acids, Peptides, and Proteins; Whey; Milk; Dairy Products; Food; Diet, Food, and Nutrition; Physiological Phenomena; Food and Beverages

Study Officials

• Philip D Chilibeck, PhD

  University of Saskatchewan

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: QUADRUPLE
• Who Masked: PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Ph.D.

Study Record Dates

• First Submitted: February 4, 2013
• First Posted: February 15, 2013
• Study Start: December 1, 2012
• Primary Completion: February 1, 2013
• Study Completion: February 1, 2013
• Last Updated: May 5, 2017

Record last verified: 2017-05

Locations

CA (1)