NCT01783912

Brief Summary

This study tests whether pre-cessation interventions known to be effective in the general population will increase acceptance of evidence-based treatment, engagement and compliance with that treatment and initial quitting success. One hundred and seventy two patients will be recruited from 13 Community Support Programs (CSPs). CSPs provide community based care to those diagnosed with persistent and serious mental illness. All participants will receive two group sessions (40 minutes each) modeled after "Kicking Butts", a group-based quitting preparation program used for the past four years in two Milwaukee CSP programs run by Wisconsin Community Services. Individuals will then be randomly assigned to the experimental and control conditions (n=86 each). Experimental subjects will receive four evidence-based preparatory interventions (motivational interviewing, smoking reduction, practice quit attempt, and pre-quit use of nicotine replacement medication) (25 - 30 minutes each). Attention control subjects will also receive four individual sessions of the same duration. However their individual sessions' content will be a discussion of the personal relevance of the group material and will not include any of the preparatory interventions. Data will be collected via brief surveys taken pre-intervention, at the end of the last individual session, and three months later and from a database provided by the Wisconsin Tobacco Quit Line (WTQL).

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
270

participants targeted

Target at P75+ for phase_4

Timeline
Completed

Started Dec 2012

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

December 1, 2012

Completed
2 months until next milestone

First Submitted

Initial submission to the registry

January 22, 2013

Completed
14 days until next milestone

First Posted

Study publicly available on registry

February 5, 2013

Completed
1.3 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 1, 2014

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

June 1, 2014

Completed
1.7 years until next milestone

Results Posted

Study results publicly available

February 1, 2016

Completed
Last Updated

February 29, 2016

Status Verified

January 1, 2016

Enrollment Period

1.5 years

First QC Date

January 22, 2013

Results QC Date

December 21, 2015

Last Update Submit

January 29, 2016

Conditions

Keywords

SmokingNicotine DependenceMental Disorders

Outcome Measures

Primary Outcomes (1)

  • Acceptance of Wisconsin Tobacco Quit Line Services

    The primary outcome is participant acceptance of evidence based treatment through the WTQL at the end of the last individual session.

    4-6 weeks after study enrollment

Study Arms (3)

Cognitive/Motivational Intervention Group

EXPERIMENTAL

This arm of the project will address the following questions: After completion of experimental individual sessions, do the participants in the control group utilize the quit line services at the same, greater or lesser rate than those who are in the Active Control group? After completion of experimental individual sessions, do the participants in the control group utilize the quit line services at the same, greater or lesser rate than those who are in the Motivated Smokers Comparison group?

Behavioral: Cognitive / Motivational Individual SessionsDrug: Nicotine PatchBehavioral: Group Curriculum

Attention Control Group

ACTIVE COMPARATOR

This arm of the project will address the following question: After completion of control individual sessions, do the participants in the control group utilize the quit line services at the same, greater or lesser rate that those who are in the experimental treatment group? After completion of control individual sessions, do the participants in the control group utilize the quit line services at the same, greater or lesser rate than those who are in the Cognitive/Motivational Intervention Group?

Behavioral: Attention Control Individual SessionsBehavioral: Group Curriculum

Motivated Smokers Comparison Group

NO INTERVENTION

This arm of the project will address the following question: Do participants in the Motivated Smokers Comparison group (identified as motivated to quit upon recruitment) utilize the quit line services at the same, greater or lesser rate than those who are in the Motivated Smokers Comparison group? Do participants in the Motivated Smokers Comparison group (identified as motivated to quit upon recruitment) utilize the quit line services at the same, greater or lesser rate than those who are in the Active Control group? Participants will not receive any intervention but will be consented and enrolled into this group and assessed for utilization of the tobacco quit line services.

Interventions

Cognitive Motivational subjects will receive four evidence-based preparatory interventions (motivational interviewing, smoking reduction, practice quit attempt, and pre-quit use of nicotine replacement medication) (25 - 30 minutes each).

Cognitive/Motivational Intervention Group

Attention control subjects will receive four placebo individual sessions (25-30 minutes each). The session content will reemphasize group discussion of the personal health risks from smoking.

Attention Control Group

Cognitive Motivational subjects will be asked to take one 21 mg patch/day for 4 weeks.

Cognitive/Motivational Intervention Group

Everyone to be put into the experimental or active comparator group will attend 2 group meetings over two weeks each of which lasts 40 minutes. Experience with the Kicking Butts program indicates that this duration is well tolerated by this population. The content of these two group meetings is based on the Kicking Butts program. The Kicking Butts program was initially developed as a cessation intervention, but consistent with the literature about the need to prepare this population to make a quit attempt, has evolved to emphasize preparation for quitting. Topics addressed include the health consequences of smoking, reasons to quit and methods of quitting.

Attention Control GroupCognitive/Motivational Intervention Group

Eligibility Criteria

Age18 Years - 99 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • current smoker (smoking daily or smoking at least 10 cigarettes per week) (use of other tobacco products permitted such as chew and snuz in addition to smoking)
  • not willing to make a quit attempt
  • willingness to use the nicotine patch
  • plans to remain in the area for the next five four months.

You may not qualify if:

  • current use of any cessation medicine (nicotine patch, nicotine gum, nicotine lozenge, nicotine inhaler, nicotine nasal spray, bupropion, Wellbutrin, Zyban,Chantix or varenicline)
  • previous serious skin reaction or other allergic reaction to using the nicotine patch
  • stroke, heart attack or abnormal electrocardiogram in past four weeks
  • pregnancy, plans to get pregnant or nursing
  • exclusive use of other tobacco products (non-smoker tobacco user)
  • having a court-ordered guardian, or an activated power of attorney for health or observation by researchers during the consent procedure that suggests diminished decision making capacity

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University of Wisconsin Center for Tobacco Research and Intervention, School of Medicine and Public Health

Madison, Wisconsin, 53711, United States

Location

Related Links

MeSH Terms

Conditions

SmokingTobacco Use DisorderMental Disorders

Interventions

Tobacco Use Cessation Devices

Condition Hierarchy (Ancestors)

BehaviorSubstance-Related DisordersChemically-Induced Disorders

Intervention Hierarchy (Ancestors)

Therapeutics

Results Point of Contact

Title
Bruce Christiansen
Organization
Center for Tobacco Research and Intervention

Study Officials

  • Bruce Christiansen, PhD

    University of Wisconsin School of Medicine and Public Health, Center for Tobacco Research and Intervention

    PRINCIPAL INVESTIGATOR

Publication Agreements

PI is Sponsor Employee
No
Restrictive Agreement
No

Study Design

Study Type
interventional
Phase
phase 4
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
PARTICIPANT
Purpose
TREATMENT
Intervention Model
FACTORIAL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

January 22, 2013

First Posted

February 5, 2013

Study Start

December 1, 2012

Primary Completion

June 1, 2014

Study Completion

June 1, 2014

Last Updated

February 29, 2016

Results First Posted

February 1, 2016

Record last verified: 2016-01

Locations