Examining the Effects of Video-game Exercise on Mobility and Brain Plasticity in Individuals With Multiple Sclerosis

NCT01780792 | Completed

• 1 other identifier: 2011H0048
• Study Type: interventional
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

Dance Dance Revolution (DDR) may offer an innovative and highly effective format for delivering exercise programs to people with multiple sclerosis (MS). It is a fun, engaging and interactive video game that requires players to move their feet to targets while matching the rhythm of a song. In addition, DDR, involving both aerobic exercise and cognitive training, is an ideal intervention for improving cognitive functioning in those with MS. The purpose of this pilot study is to examine the use of DDR as a novel and highly specific exercise intervention to improve mobility and cognition among individuals with MS.

Conditions

Multiple Sclerosis

Keywords

multiple sclerosis; mobility; cognition; neuroplasticity; videogame play

Outcome Measures

Primary Outcomes (2)

• Berg Balance Scale

  The Berg Balance scale consists of 14 functional activities that test static and dynamic balance. Each item is scored on a scale of 0-4 with higher scores indicating better balance

  after 8 weeks

• PASAT

  The PASAT is a measure of sustained attention, working memory and information processing speed.

  after 8 weeks

Secondary Outcomes (7)

• 4 square step test

  after 8 weeks

• The Activities Specific Balance Confidence Scale

  after 8 weeks

• GAITRite

  after 8 weeks

• 6 minute walk test

  Immediately prior to starting the intervention/control period,, after 8 week intervention/control period and then at an 8 week follow up

• physical activity

  after 8 weeks

Study Arms (2)

Dance Dance Revolution game play

EXPERIMENTAL

Dance Dance Revolution video game play

Other: Dance Dance Revolution video game play

control

NO INTERVENTION

individuals continue usual care for 8 weeks

Interventions

Dance Dance Revolution video game play OTHER

Individuals play dance dance revolution 3 times a week for 8 weeks

Dance Dance Revolution game play

Eligibility Criteria

• Age: 30 Years - 59 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Expanded Disability Status Score of \< 5 and a diagnosis of relapsing-remitting multiple sclerosis

You may not qualify if:

• other neurological or orthopedic diagnosis that limits ambulation, age 30-59

Sponsors & Collaborators

• Ohio State University: lead

Study Sites (1)

The Ohio State University Atwell Hall

Columbus, Ohio, 43210, United States

Location

MeSH Terms

Conditions

Multiple Sclerosis

Condition Hierarchy (Ancestors)

Demyelinating Autoimmune Diseases, CNS; Autoimmune Diseases of the Nervous System; Nervous System Diseases; Demyelinating Diseases; Autoimmune Diseases; Immune System Diseases

Study Officials

• Deb Kegelmeyer, DPT, MS

  Ohio State University

  PRINCIPAL INVESTIGATOR

• Ruchika Prakash, PhD

  Ohio State University

  PRINCIPAL INVESTIGATOR

• Anne Kloos, PT, PhD

  Ohio State University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: INVESTIGATOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: November 7, 2012
• First Posted: January 31, 2013
• Study Start: August 1, 2011
• Primary Completion: August 1, 2015
• Study Completion: December 1, 2016
• Last Updated: April 7, 2017

Record last verified: 2017-04

Locations

US (1)