Detection of Methylated Reprimo in Plasma for Asymptomatic Gastric Cancer
DEMRAC
Screening and Triage Test for Early Detection of Gastric Cancer
2 other identifiers
observational
3,000
1 country
1
Brief Summary
In this proposal the investigators aim to develop a commercial kit to be used in primary screening and non-invasive triage for early detection of gastric cancer. This kit will be cost-effective and more accessible to the general population. In addition, the investigators would like to expand our current patent already submitted to INAPI (National Institute for Intellectual Property) and propose royalties to biomedical diagnostic companies for the use of our product at international level.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Sep 2012
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
September 1, 2012
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2012
CompletedFirst Submitted
Initial submission to the registry
January 19, 2013
CompletedFirst Posted
Study publicly available on registry
January 23, 2013
CompletedStudy Completion
Last participant's last visit for all outcomes
March 1, 2014
CompletedJune 3, 2013
May 1, 2013
3 months
January 19, 2013
May 30, 2013
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Early detection of gastric cancer
Increase the frequency of early detection rate of gastric cancer
2 years
Secondary Outcomes (1)
Monitoring progression of disease
2 years
Other Outcomes (1)
Detection of H.pylori and gastric atrophy
2 years
Study Arms (1)
Molina - Chile
Molina is one of the counties with the highest mortality rate of gastric cancer in Chile. Molina has a population of 40.000 hab mostly rural. Half of the population lives in Molina city and the other half in the suburbs. Molina is located near the Mountain Andes.
Eligibility Criteria
3000 population base study from rural area in south of Chile. This is area has one of the highest incidence of gastric cancer in the world (35/100.000).
You may qualify if:
- Male or Female
- Age 40-70 y.o.
You may not qualify if:
- Gastric Cancer
- Dyspepsia
- Bleeding disorders
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Pontificia Universidad Catolica de Chilelead
- Ministerio de Salud de Chilecollaborator
- Hoffmann-La Rochecollaborator
- Red Salud UCcollaborator
Study Sites (1)
Hospital Santa Rosa de Molina
Molina, Maule Region, 8320000, Chile
Related Publications (2)
Bernal C, Aguayo F, Villarroel C, Vargas M, Diaz I, Ossandon FJ, Santibanez E, Palma M, Aravena E, Barrientos C, Corvalan AH. Reprimo as a potential biomarker for early detection in gastric cancer. Clin Cancer Res. 2008 Oct 1;14(19):6264-9. doi: 10.1158/1078-0432.CCR-07-4522.
PMID: 18829507BACKGROUNDCarrasco G, Corvalan AH. Helicobacter pylori-Induced Chronic Gastritis and Assessing Risks for Gastric Cancer. Gastroenterol Res Pract. 2013;2013:393015. doi: 10.1155/2013/393015. Epub 2013 Jul 29.
PMID: 23983680DERIVED
Related Links
Biospecimen
Blood and biopsy samples are collected
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
January 19, 2013
First Posted
January 23, 2013
Study Start
September 1, 2012
Primary Completion
December 1, 2012
Study Completion
March 1, 2014
Last Updated
June 3, 2013
Record last verified: 2013-05