NCT01763840

Brief Summary

The research protocol aims to compare the utility of contrast enhanced abdominal sonography with computerized tomography in the evaluation of children with blunt abdominal trauma. Hemodynamically stable children ages 7-18 who are transferred to Children's Hospital on the trauma service with a CT scan of abdomen \& pelvis already performed at the referring institution will be identified by the trauma service as eligible for inclusion. The ultrasounds will be performed by one of two Attending Radiologists involved in the study. The contrast being used for the study is Optison (GE Healthcare Inc, Princeton, NJ), which is an injectable suspension of Perflutren Protein-Type A Microspheres. This has been used in echocardiography as well as abdominal ultrasonography for evaluation of pediatric abdominal and pelvic solid tumors. The contrast enhanced ultrasound will be performed by radiologist. Contrast enhancement only lasts for 3-5 minutes per injection, therefore Optison will be redosed up to 2 additional doses for the completion of the ultrasound. Vital signs will be monitored for 30 minutes after the contrast agent is given and any adverse reactions will be recorded. Adverse reactions to Optison have occurred within this time frame in the literature. Subsequent medical care will be as indicated per the clinical practice guideline.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
18

participants targeted

Target at P25-P50 for phase_1

Timeline
Completed

Started Apr 2013

Typical duration for phase_1

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

January 4, 2013

Completed
5 days until next milestone

First Posted

Study publicly available on registry

January 9, 2013

Completed
3 months until next milestone

Study Start

First participant enrolled

April 1, 2013

Completed
2.5 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

October 1, 2015

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

October 1, 2015

Completed
Last Updated

January 31, 2017

Status Verified

January 1, 2017

Enrollment Period

2.5 years

First QC Date

January 4, 2013

Last Update Submit

January 30, 2017

Conditions

Abdominal Trauma

Keywords

Pediatric Abdominal Trauma Ultrasound Contrast

Outcome Measures

Primary Outcomes (1)

  • Primary outcome measured will be the identification of intra-abdominal injury

    Baseline

Secondary Outcomes (1)

  • Secondary outcome will be assessment of grade of solid organ injury.

    Baseline

Study Arms (1)

Contrast enhanced Ultrasound

EXPERIMENTAL

Presence and grade of solid organ injury on contrast enhanced ultrasound

Drug: Contrast enhanced Ultrasound

Interventions

Contrast enhanced UltrasoundDRUG

Ultrasound, then contrast enhanced ultrasound.

Also known as: Optison
Contrast enhanced Ultrasound

Eligibility Criteria

Age2 Years - 35 Years
Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64)

You may qualify if:

  • Hemodynamically stable
  • Age 10-18 years
  • Transferred to BCH Emergency Department to the Trauma Service for evaluation and management
  • Concern for blunt abdominal injury
  • CT A/P performed at referring institution
  • Planned for admission to the hospital on the trauma service

You may not qualify if:

  • Patients who are hemodynamically unstable
  • Known cardiac abnormality
  • Pulmonary hypertension
  • Known sensitivity to human albumin or blood products
  • Unable to roll over
  • Unable to assent
  • Pregnant
  • Lactating

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Boston Children's Hospital

Boston, Massachusetts, 02115, United States

Location

Related Publications (8)

  • Dolan MS, Gala SS, Dodla S, Abdelmoneim SS, Xie F, Cloutier D, Bierig M, Mulvagh SL, Porter TR, Labovitz AJ. Safety and efficacy of commercially available ultrasound contrast agents for rest and stress echocardiography a multicenter experience. J Am Coll Cardiol. 2009 Jan 6;53(1):32-8. doi: 10.1016/j.jacc.2008.08.066.

    PMID: 19118722BACKGROUND

  • Abdelmoneim SS, Bernier M, Scott CG, Dhoble A, Ness SA, Hagen ME, Moir S, McCully RB, Pellikka PA, Mulvagh SL. Safety of contrast agent use during stress echocardiography in patients with elevated right ventricular systolic pressure: a cohort study. Circ Cardiovasc Imaging. 2010 May;3(3):240-8. doi: 10.1161/CIRCIMAGING.109.895029. Epub 2010 Mar 16.

    PMID: 20233859BACKGROUND

  • Darge K; CEUS task force of the Society for Pediatric Radiology. Contrast-enhanced US (CEUS) in children: ready for prime time in the United States. Pediatr Radiol. 2011 Nov;41(11):1486-8. doi: 10.1007/s00247-011-2240-y. Epub 2011 Sep 22. No abstract available.

    PMID: 21938505BACKGROUND

  • McCarville MB. Contrast-enhanced sonography in pediatrics. Pediatr Radiol. 2011 May;41 Suppl 1:S238-42. doi: 10.1007/s00247-011-2005-7. Epub 2011 Apr 27.

    PMID: 21523607BACKGROUND

  • McCarville MB, Kaste SC, Hoffer FA, Khan RB, Walton RC, Alpert BS, Furman WL, Li C, Xiong X. Contrast-enhanced sonography of malignant pediatric abdominal and pelvic solid tumors: preliminary safety and feasibility data. Pediatr Radiol. 2012 Jul;42(7):824-33. doi: 10.1007/s00247-011-2338-2. Epub 2012 Jan 17.

    PMID: 22249601BACKGROUND

  • McMahon CJ, Ayres NA, Bezold LI, Lewin MB, Alonzo M, Altman CA, Kovalchin JP, Eidem BW, Pignatelli RH. Safety and efficacy of intravenous contrast imaging in pediatric echocardiography. Pediatr Cardiol. 2005 Jul-Aug;26(4):413-7. doi: 10.1007/s00246-004-0795-1.

    PMID: 16374692BACKGROUND

  • Valentino M, Serra C, Pavlica P, Labate AM, Lima M, Baroncini S, Barozzi L. Blunt abdominal trauma: diagnostic performance of contrast-enhanced US in children--initial experience. Radiology. 2008 Mar;246(3):903-9. doi: 10.1148/radiol.2463070652. Epub 2008 Jan 14.

    PMID: 18195385BACKGROUND

  • Wei K, Mulvagh SL, Carson L, Davidoff R, Gabriel R, Grimm RA, Wilson S, Fane L, Herzog CA, Zoghbi WA, Taylor R, Farrar M, Chaudhry FA, Porter TR, Irani W, Lang RM. The safety of deFinity and Optison for ultrasound image enhancement: a retrospective analysis of 78,383 administered contrast doses. J Am Soc Echocardiogr. 2008 Nov;21(11):1202-6. doi: 10.1016/j.echo.2008.07.019. Epub 2008 Oct 10.

    PMID: 18848430BACKGROUND

MeSH Terms

Conditions

Abdominal Injuries

Interventions

FS 069

Condition Hierarchy (Ancestors)

Wounds and Injuries

Study Officials

  • Jill Zalieckas, MD

    Boston Children's Hospital

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
phase 1
Allocation
NA
Masking
NONE
Purpose
DIAGNOSTIC
Intervention Model
SINGLE GROUP
Sponsor Type
OTHER
Responsible Party
SPONSOR INVESTIGATOR
PI Title
Associate Professor of Surgery

Study Record Dates

First Submitted

January 4, 2013

First Posted

January 9, 2013

Study Start

April 1, 2013

Primary Completion

October 1, 2015

Study Completion

October 1, 2015

Last Updated

January 31, 2017

Record last verified: 2017-01

Locations

US(1)