NCT01760018

Brief Summary

Total intravenous anesthesia (TIVA) and inhalation anesthesia are both widely and safely used, and there are many clinical trials comparing these on various aspects of anesthesia. However, there have not been studies comparing the quality of recovery from the different methods of general anesthesia. In this study, the investigators compare the functional recovery after general anesthesia in TIVA and inhalation anesthesia with QoR-40 questionnaire.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
76

participants targeted

Target at P50-P75 for not_applicable

Timeline
Completed

Started Dec 2012

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

December 1, 2012

Completed
1 month until next milestone

First Submitted

Initial submission to the registry

December 31, 2012

Completed
1 day until next milestone

Primary Completion

Last participant's last visit for primary outcome

January 1, 2013

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

January 1, 2013

Completed
2 days until next milestone

First Posted

Study publicly available on registry

January 3, 2013

Completed
Last Updated

February 19, 2014

Status Verified

February 1, 2014

Enrollment Period

1 month

First QC Date

December 31, 2012

Last Update Submit

February 17, 2014

Conditions

Thyroid Operation Under General Anesthesia

Keywords

desflurane, total intravenous anesthesia, QoR-40

Outcome Measures

Primary Outcomes (1)

  • QoR-40 score

    QoR-40 score is going to be measured at preoperative period, 24 hours, and 48 hours later after surgery.

    at 24 hours later after surgery

Study Arms (2)

Desflurane group

EXPERIMENTAL
Drug: desflurane group

TIVA(total intravenous anesthesia) group

ACTIVE COMPARATOR
Drug: TIVA group

Interventions

desflurane groupDRUG

anesthesia is maintained with desflurane and remifentanil (Desflurane group)

Desflurane group
TIVA groupDRUG

anesthesia is maintained with fresofol and remifentanil (TIVA group).

TIVA(total intravenous anesthesia) group

Eligibility Criteria

Age20 Years - 65 Years
Sexfemale
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • patients who are undergoing thyroid operation belong to ASA class 1 or 2

You may not qualify if:

  • patients who are belongs to ASA class 3 or more,
  • patients who have underlying complicated cardiovascular or psychological disease.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Severance Hospital

Seoul, Seoul, 120-752, South Korea

Location

Related Publications (2)

  • Myles PS, Weitkamp B, Jones K, Melick J, Hensen S. Validity and reliability of a postoperative quality of recovery score: the QoR-40. Br J Anaesth. 2000 Jan;84(1):11-5. doi: 10.1093/oxfordjournals.bja.a013366.

    PMID: 10740540BACKGROUND

  • Lee WK, Kim MS, Kang SW, Kim S, Lee JR. Type of anaesthesia and patient quality of recovery: a randomized trial comparing propofol-remifentanil total i.v. anaesthesia with desflurane anaesthesia. Br J Anaesth. 2015 Apr;114(4):663-8. doi: 10.1093/bja/aeu405. Epub 2014 Dec 10.

    PMID: 25500679DERIVED

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
PARTICIPANT, INVESTIGATOR
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

December 31, 2012

First Posted

January 3, 2013

Study Start

December 1, 2012

Primary Completion

January 1, 2013

Study Completion

January 1, 2013

Last Updated

February 19, 2014

Record last verified: 2014-02

Locations

KR(1)