The Effect of Anesthetics Agents on Vascular Injury and Level of Syndecan-1 During Knee Surgery
1 other identifier
interventional
80
1 country
1
Brief Summary
Ischeic reperfusion injury lead to a cellular dyfunction and increase in soluble glycocalyx of blood flow. syndecan-1 was a marker of glycocalyx. The purpose of this study is to prove the variation of level of serum syndecan-1 between preoperative and postoperative period.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for not_applicable
Started May 2016
Longer than P75 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
April 28, 2016
CompletedFirst Posted
Study publicly available on registry
April 29, 2016
CompletedStudy Start
First participant enrolled
May 30, 2016
CompletedPrimary Completion
Last participant's last visit for primary outcome
March 26, 2018
CompletedStudy Completion
Last participant's last visit for all outcomes
February 27, 2020
CompletedFebruary 28, 2020
February 1, 2020
1.8 years
April 28, 2016
February 27, 2020
Conditions
Outcome Measures
Primary Outcomes (1)
Syndecan-1
change of level of syndecan-1 (scores range from 0 to 100)
Preoperative time, Immediate before tourniquet off,5 min after tourniquet off,PACU, postoperation after 6hours, postoperation after 24hours
Study Arms (2)
propofol group
ACTIVE COMPARATORThe patient who anesthetized by using propofol.
Desflurane group
ACTIVE COMPARATORThe patient who anesthetized by using sevoflurane.
Interventions
Patient will be anesthetized by using propofol infusion during operation.
Patient will be anesthetized by using desflurane inhalation during operation.
Eligibility Criteria
You may qualify if:
- patients who was planned to undergo knee surgery.
You may not qualify if:
- age \< 20 years old
- history of previous cancer
- history of previous peripheral vascular disease
- Emergency surgery
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Konkuk University Medical Center
Seoul, 143-729, South Korea
Related Publications (1)
Oh CS, Choi JM, Park EH, Piao L, Park HJ, Rhee KY, Kim SH. Impact of Anesthetic Agents on Endothelial Glycocalyx Injury during Total Knee Arthroplasty: Desflurane- vs. Propofol-Based Anesthesia-A Prospective Randomized Controlled Trial. Biomed Res Int. 2021 Jan 23;2021:8880267. doi: 10.1155/2021/8880267. eCollection 2021.
PMID: 33564684DERIVED
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Seong-Hyop Kim, M.D,Ph.D
Konkuk University Medical Center
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- INVESTIGATOR
- Purpose
- BASIC SCIENCE
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Associate Professor
Study Record Dates
First Submitted
April 28, 2016
First Posted
April 29, 2016
Study Start
May 30, 2016
Primary Completion
March 26, 2018
Study Completion
February 27, 2020
Last Updated
February 28, 2020
Record last verified: 2020-02
Data Sharing
- IPD Sharing
- Will not share