Carbon Monoxide Blood and DNA Biorepository

NCT01758653 | Enrolling By Invitation

• 1 other identifier: 1024109
• Study Type: observational
• Target: 300
• Locations: 1 country
• Sites: 2

Brief Summary

The purpose of this biorepository is to collect blood from patients at the time of CO poisoning and at follow-up visits months to years later. These samples can be used in the future to learn more about how CO damages the heart and brain and whether blood tests could predict which patients will have problems after CO poisoning.

Conditions

Carbon Monoxide Poisoning

Keywords

CO poisoning

Outcome Measures

Primary Outcomes (1)

• Biorepository for serum and plasma

  Serum and plasma from blood collected within 24 hours of acute CO poisoning

  Within 24 hours of CO Poisoning

Secondary Outcomes (3)

• Serum and plasma (sub-acute)

  4 weeks to 4 months after CO poisoning

• DNA Sequestration

  24 hours to 12 months after CO poisoning

• Serum and plasma (long-term)

  4 months to 12 months after CO poisoning

Study Arms (1)

Biorepository

Patients with acute CO poisoning. Blood collection for biorepository only, no study intervention.

Other: No study intervention

Interventions

No study intervention OTHER

There is no study-related intervention.

Biorepository

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Study population includes patients who present to LDS Hospital or Intermountain Medical Center with symptomatic carbon monoxide poisoning and documented exposure to carbon monoxide.

You may qualify if:

• Symptomatic carbon monoxide poisoning (headache, nausea, vomiting, dizziness, fatigue, muscle aches, slowed mentation, confusion, loss of consciousness, etc.).
• Documented exposure to carbon monoxide and no other reasonable explanation for their signs and symptoms.

You may not qualify if:

• Pregnancy
• Age \< 18 years
• Unable to obtain informed consent
• Anemia requiring blood products within the last 4 months or hematocrit less than the laboratory normal reference range

Sponsors & Collaborators

• Intermountain Health Care, Inc.: lead

Study Sites (2)

Intermountain Medical Center

Murray, Utah, 84107, United States

Location

LDS Hospital

Salt Lake City, Utah, 84143, United States

Location

Biospecimen

Retention: SAMPLES WITH DNA

Blood for plasma, serum, and DNA sequestration

MeSH Terms

Conditions

Carbon Monoxide Poisoning

Condition Hierarchy (Ancestors)

Gas Poisoning; Poisoning; Chemically-Induced Disorders

Study Officials

• Lindell K. Weaver, MD

  Intermountain Health Care, Inc.

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Lindell Weaver, MD

Study Record Dates

• First Submitted: December 27, 2012
• First Posted: January 1, 2013
• Study Start: February 1, 2012
• Primary Completion (Estimated): December 1, 2032
• Study Completion (Estimated): December 1, 2032
• Last Updated: September 29, 2023

Record last verified: 2023-09

Locations

US (2)