Magnetic Resonance Elastography as a Method to Estimate Stiffness of Soft Tissues

NCT01757730 | Recruiting DMC

• 1 other identifier: 2012H0027
• Study Type: observational
• Target: 1,000
• Locations: 1 country
• Sites: 1

Brief Summary

Magnetic resonance elastography is a novel non-invasive MRI technique to obtain stiffness of soft tissues such as liver, heart, kidneys, etc. In this imaging technique a person is laid in an MR scanner and a paddle (plastic drum) is put on the area of interest to send sound vibration via a speaker placed outside the scan room which is connecting plastic drum via a plastic tube. These vibrations are scanned using MRI to estimate the stiffness of soft tissues such as liver, heart, kidneys, breast etc.

Conditions

Heart Failure; Liver Fibrosis; Cardiac Transplant Rejection; Aortic Aneurysms

Outcome Measures

Primary Outcomes (1)

• Stiffness of soft tissues

  Estimate any variation in stiffness

  Participants will be followed for the duration of hospital stay, ecah clinical visit after discharge for an expected average up to 1 year

Study Arms (2)

Altered Stiffness

Tissue stiffness will be evaluated in subjects those with disease conditions where stiffness changes from normal. These studies will be repeated for reproducibility.

Healthy Volunteers

Tissue stiffness will be evaluated in normal subjects to determine the normal values. These studies will be repeated for reproducibility.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

1. You are 18 and over and affected by a certain disease condition such as Heart/Kidney/Lung/liver/spleen or aortic aneurysms or any other kind of diseases where stiffness of the soft tissue is thought to change. 2. You are 18 and over and a healthy volunteer and not affected by any of the conditions mentioned in #1 above.

You may qualify if:

• Any participant 18 years or older and are MR safe.

You may not qualify if:

• That study participants will be excluded if they have any unapproved metal in their bodies, or if the volunteers are pregnant or possible of becoming pregnant. Also if the participants are claustrophobic.

Sponsors & Collaborators

• Arunark Kolipaka: lead

Study Sites (1)

The Ohio State University Wexner Medical Center

Columbus, Ohio, 43210, United States

RECRUITING

Related Publications (5)

• Damughatla AR, Raterman B, Sharkey-Toppen T, Jin N, Simonetti OP, White RD, Kolipaka A. Quantification of aortic stiffness using MR elastography and its comparison to MRI-based pulse wave velocity. J Magn Reson Imaging. 2015 Jan;41(1):44-51. doi: 10.1002/jmri.24506. Epub 2013 Nov 15.

  PMID: 24243654 RESULT

• Chamarthi SK, Raterman B, Mazumder R, Michaels A, Oza VM, Hanje J, Bolster B, Jin N, White RD, Kolipaka A. Rapid acquisition technique for MR elastography of the liver. Magn Reson Imaging. 2014 Jul;32(6):679-83. doi: 10.1016/j.mri.2014.02.013. Epub 2014 Feb 13.

  PMID: 24637083 RESULT

• Kenyhercz WE, Raterman B, Illapani VS, Dowell J, Mo X, White RD, Kolipaka A. Quantification of aortic stiffness using magnetic resonance elastography: Measurement reproducibility, pulse wave velocity comparison, changes over cardiac cycle, and relationship with age. Magn Reson Med. 2016 May;75(5):1920-6. doi: 10.1002/mrm.25719. Epub 2015 Jun 12.

  PMID: 26096227 RESULT

• Wassenaar PA, Eleswarpu CN, Schroeder SA, Mo X, Raterman BD, White RD, Kolipaka A. Measuring age-dependent myocardial stiffness across the cardiac cycle using MR elastography: A reproducibility study. Magn Reson Med. 2016 Apr;75(4):1586-93. doi: 10.1002/mrm.25760. Epub 2015 May 22.

  PMID: 26010456 RESULT

• Moldovan L, Anghelina M, Kantor T, Jones D, Ramadan E, Xiang Y, Huang K, Kolipaka A, Malarkey W, Ghasemzadeh N, Mohler PJ, Quyyumi A, Moldovan NI. A module of human peripheral blood mononuclear cell transcriptional network containing primitive and differentiation markers is related to specific cardiovascular health variables. PLoS One. 2014 Apr 23;9(4):e95124. doi: 10.1371/journal.pone.0095124. eCollection 2014.

  PMID: 24759906 RESULT

MeSH Terms

Conditions

Heart Failure; Liver Cirrhosis; Aortic Aneurysm

Condition Hierarchy (Ancestors)

Heart Diseases; Cardiovascular Diseases; Liver Diseases; Digestive System Diseases; Fibrosis; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Aneurysm; Vascular Diseases; Aortic Diseases

Study Officials

• Arunark Kolipaka, PhD

  Ohio State University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Arunark Kolipaka

CONTACT

614-366-0268; arunark.kolipaka@osumc.edu

Kristin L Thompson, B.S.

CONTACT

614-366-5429; Kristin.Thompson@osumc.edu

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: December 18, 2012
• First Posted: December 31, 2012
• Study Start: March 1, 2012
• Primary Completion (Estimated): March 1, 2028
• Study Completion (Estimated): March 1, 2028
• Last Updated: April 6, 2025

Record last verified: 2025-04

Locations

US (1)