SILVER-AMI: Outcomes in Older Persons With Heart Attacks
SILVER-AMI
SILVER-AMI: Risk Stratification in Older Persons With Acute Myocardial Infarction
2 other identifiers
observational
3,042
1 country
81
Brief Summary
SILVER-AMI is a research study of older persons who are admitted to the hospital with a heart attack. Patients will be interviewed in the hospital and again 6 months later. The researchers will also collect detailed medical record information to understand the effect of heart attacks on older persons. The research team at Yale University will use this information to develop a risk model that can be used to help doctors predict recovery. The goal of the study is to help older people in the future make well-informed decisions about their health care during a heart attack.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Jan 2013
Longer than P75 for all trials
81 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
November 27, 2012
CompletedFirst Posted
Study publicly available on registry
December 21, 2012
CompletedStudy Start
First participant enrolled
January 1, 2013
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 1, 2018
CompletedStudy Completion
Last participant's last visit for all outcomes
June 1, 2018
CompletedMay 28, 2019
May 1, 2019
5.4 years
November 27, 2012
May 23, 2019
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
All-cause hospital readmission
up to six months
Secondary Outcomes (2)
All-cause mortality
Up to six months
Decline in health status
up to six months
Eligibility Criteria
Older adults admitted to the hospital with a heart attack
You may qualify if:
- Age ≥75 years upon admission to the hospital
- Elevation of cardiac markers within 24 hours of presentation to the hospital
- a. Troponin must rise above the upper limit of normal established by the hospital as a determinate of cardiac injury.
- Any one of the following:
- Symptoms of ischemia
- ECG with ischemic changes
- Imaging evidence of Infarction
- Intracoronary thrombus on angiography
You may not qualify if:
- Patient transferred from another hospital with a length of stay \>48 hours at the referring hospital.
- Refused Informed Consent
- Decisional impairment with no legally authorized representative
- AMI is secondary to chest trauma
- AMI is secondary to in-patient procedure or surgery
- History of heart transplant
- Non-English/Non-Spanish speaking
- Inability to complete interview (e.g. comatose or aphasia)
- Inability to contact for follow-up (e.g. no access to phone, not living in the country)
- Currently a prisoner
- Death prior to enrollment
- Previously enrolled in SILVER-AMI
- Troponin elevation is the result of apical ballooning syndrome (i.e., Takotsubo)
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Yale Universitylead
- National Heart, Lung, and Blood Institute (NHLBI)collaborator
Study Sites (81)
Sparks Regional Medical Center
Fort Smith, Arkansas, 72901, United States
Los Alamitos Internal Medical Group
Los Alamitos, California, 90720, United States
Mercy General Hospital
Sacramento, California, 95816, United States
Santa Barbara Cottage Hospital
Santa Barbara, California, 93105, United States
St. Joseph's Medical Center
Stockton, California, 95204, United States
Torrance Memorial Medical Center
Torrance, California, 90505, United States
University of Colorado
Aurora, Colorado, 80045, United States
Denver Health Medical Center
Denver, Colorado, 80204, United States
Bridgeport Hospital
Bridgeport, Connecticut, 06610, United States
The Danbury Hospital and the Western Connecticut Medical
Danbury, Connecticut, 06810, United States
Saint Francis Hospital and Medical Center
Hartford, Connecticut, 06105, United States
Yale University
New Haven, Connecticut, 06511, United States
Florida Hospital Pepin Heart Institute
Tampa, Florida, 33613, United States
Emory University
Atlanta, Georgia, 30322, United States
The Corporation of Mercer University
Macon, Georgia, 31201, United States
South Georgia Medical Center
Valdosta, Georgia, 31602, United States
The Queen's Medical Center
Honolulu, Hawaii, 96813, United States
Saint Alphonsus Regional Medical Center
Boise, Idaho, 83706, United States
Northwestern Memorial Hospital
Chicago, Illinois, 60611, United States
Rush University Medical Center
Chicago, Illinois, 60612, United States
The University Of Chicago
Chicago, Illinois, 60637, United States
Northshore University Health System
Evanston, Illinois, 60201, United States
Parkview Research Center
Fort Wayne, Indiana, 46845, United States
St. Francis Medical Group
Indianapolis, Indiana, 46237, United States
Iowa Heart Center
Des Moines, Iowa, 50314, United States
University of Iowa Hospitals and Clinics
Iowa City, Iowa, 52242, United States
Cardiovascular Research Foundation of Louisiana
Baton Rouge, Louisiana, 70808, United States
Meritus Medical Center
Hagerstown, Maryland, 21740, United States
Brigham and Women's Hospital, Inc.
Boston, Massachusetts, 02115, United States
Boston Medical Center
Boston, Massachusetts, 02118, United States
Beth Israel Deaconess Medical Center
Boston, Massachusetts, 02215, United States
UMass Memorial Medical Center
Worcester, Massachusetts, 01605, United States
University of Michigan Health Systems
Ann Arbor, Michigan, 48109-1287, United States
Oakwood Hospital and Medical Center
Dearborn, Michigan, 48123, United States
St. John Hospital & Medical Center
Detroit, Michigan, 48236, United States
Spectrum Health Hospitals
Grand Rapids, Michigan, 49503, United States
McLaren Cardiovascular Group
Okemos, Michigan, 48864, United States
Munson Medical Center
Traverse City, Michigan, 49684, United States
Metropolitan Cardiology Consultants
Coon Rapids, Minnesota, 55433, United States
Minneapolis Heart Institute Foundation
Minneapolis, Minnesota, 55407, United States
Mayo Clinic
Rochester, Minnesota, 55905, United States
Mid America Heart Institute St. Luke's Hospital
Kansas City, Missouri, 64111, United States
Cox Health
Springfield, Missouri, 65807, United States
Washington University
St Louis, Missouri, 63110, United States
The International Heart Institute of Montana
Missoula, Montana, 59802, United States
Nebraska Specialty Network
Lincoln, Nebraska, 68526, United States
CHI-Health-Alegent Creighton Research
Omaha, Nebraska, 68124, United States
Advanced Heart Care, LLC
Bridgewater, New Jersey, 08807, United States
Englewood Hospital and Medical Center
Englewood, New Jersey, 07631, United States
Hackensack University Medical Center
Hackensack, New Jersey, 07601, United States
Overlook Medical Center
Summit, New Jersey, 07901, United States
Presbyterian Heart Group
Albuquerque, New Mexico, 87106, United States
New York University School of Medicine
New York, New York, 10016, United States
The Trustees of Columbia University in the City of New York
New York, New York, 10034, United States
St. Francis Research & Educational Corporation
Roslyn, New York, 11576, United States
The Research Foundation for the State University of New York
Stony Brook, New York, 11794-8167, United States
Montefiore/Albert Einstein Medical Center
The Bronx, New York, 10461, United States
Mission Medical Associates, Inc. dba Asheville Cardiology Associates
Asheville, North Carolina, 28803, United States
University of North Carolina at Chapel Hill
Chapel Hill, North Carolina, 27599, United States
Forsyth Medical Center
Winston-Salem, North Carolina, 27103, United States
Wake Forest University Health Sciences
Winston-Salem, North Carolina, 27157-1045, United States
Sanford Research
Fargo, North Dakota, 57104, United States
Oklahoma Heart Hospital Research Foundation
Oklahoma City, Oklahoma, 73120, United States
Good Samaritan Hospital, Corvallis
Corvallis, Oregon, 97330, United States
Providence Health & Services
Portland, Oregon, 97225, United States
OHSU: Oregon Health & Science University
Portland, Oregon, 97239, United States
Portland VA Medical Center
Portland, Oregon, 97239, United States
Doylestown Hospital
Doylestown, Pennsylvania, 18901, United States
Thomas Jefferson University
Philadelphia, Pennsylvania, 19107, United States
University of Pittsburgh Medical Center
Pittsburgh, Pennsylvania, 15261, United States
Donald Guthrie Foundation for Education and Research
Sayre, Pennsylvania, 18840, United States
Lankenau Hospital
Wynnewood, Pennsylvania, 19096, United States
Rhode Island Hospital
Providence, Rhode Island, 02903, United States
Rapid City Regional Hospital, Inc.
Rapid City, South Dakota, 57701, United States
Providence Healthcare Network
Waco, Texas, 76712, United States
Stroobants Cardiovascular Center
Lynchburg, Virginia, 24501, United States
Sentara Hospital
Norfolk, Virginia, 23507, United States
Virginia Commonwealth University
Richmond, Virginia, 23298, United States
St Mary's Medical Center
Huntington, West Virginia, 25702, United States
Bellin Memorial Hospital, Inc.
Green Bay, Wisconsin, 54301, United States
Aurora Research Institute
Milwaukee, Wisconsin, 53233, United States
Related Publications (3)
Dodson JA, Hajduk AM, Geda M, Krumholz HM, Murphy TE, Tsang S, Tinetti ME, Nanna MG, McNamara R, Gill TM, Chaudhry SI. Predicting 6-Month Mortality for Older Adults Hospitalized With Acute Myocardial Infarction: A Cohort Study. Ann Intern Med. 2020 Jan 7;172(1):12-21. doi: 10.7326/M19-0974. Epub 2019 Dec 10.
PMID: 31816630DERIVEDDodson JA, Hajduk AM, Murphy TE, Geda M, Krumholz HM, Tsang S, Nanna MG, Tinetti ME, Goldstein D, Forman DE, Alexander KP, Gill TM, Chaudhry SI. Thirty-Day Readmission Risk Model for Older Adults Hospitalized With Acute Myocardial Infarction. Circ Cardiovasc Qual Outcomes. 2019 May;12(5):e005320. doi: 10.1161/CIRCOUTCOMES.118.005320.
PMID: 31010300DERIVEDDodson JA, Geda M, Krumholz HM, Lorenze N, Murphy TE, Allore HG, Charpentier P, Tsang SW, Acampora D, Tinetti ME, Gill TM, Chaudhry SI. Design and rationale of the comprehensive evaluation of risk factors in older patients with AMI (SILVER-AMI) study. BMC Health Serv Res. 2014 Nov 5;14:506. doi: 10.1186/s12913-014-0506-4.
PMID: 25370536DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Sarwat Chaudhry, MD
Yale University
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
November 27, 2012
First Posted
December 21, 2012
Study Start
January 1, 2013
Primary Completion
June 1, 2018
Study Completion
June 1, 2018
Last Updated
May 28, 2019
Record last verified: 2019-05