Examining Heart Attacks in Young Women
VIRGO
Variation in Recovery: Role of Gender on Outcomes of Young Acute Myocardial Infarction (AMI) Patients (VIRGO)
2 other identifiers
observational
2,985
1 country
92
Brief Summary
Heart disease and heart attacks pose a serious health risk to young women, and women tend to experience less successful recoveries after a heart attack than men do. This study will examine various factors that may predispose women to heart attacks and to poor recovery after a heart attack. The differences between men and women in the medical care that they receive following a heart attack will also be studied.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Sep 2007
Longer than P75 for all trials
92 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
September 1, 2007
CompletedFirst Submitted
Initial submission to the registry
January 9, 2008
CompletedFirst Posted
Study publicly available on registry
January 18, 2008
CompletedPrimary Completion
Last participant's last visit for primary outcome
February 1, 2013
CompletedStudy Completion
Last participant's last visit for all outcomes
February 1, 2013
CompletedMarch 30, 2020
June 1, 2014
5.4 years
January 9, 2008
March 27, 2020
Conditions
Keywords
Study Arms (2)
1
2,000 women between the ages of 18 and 55 years who are hospitalized with a heart attack
2
1,000 men between the ages of 18 and 55 years who are hospitalized with a heart attack
Eligibility Criteria
2,000 women and 1,000 men between the ages of 18 and 55 years who are hospitalized with a heart attack
You may qualify if:
- Elevated cardiac markers within 24 hours of arrival at initial or enrolling institution
- Supporting evidence suggestive of a heart attack
You may not qualify if:
- Previously enrolled in the VIRGO study
- Does not speak English or Spanish
- Too ill to interview
- Current prisoner
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Yale Universitylead
- National Heart, Lung, and Blood Institute (NHLBI)collaborator
Study Sites (92)
University of Alabama at Birmingham
Birmingham, Alabama, 35294-0007, United States
Providence Hospital
Mobile, Alabama, 36685, United States
Sharp Gross Hospital
La Mesa, California, 91942, United States
Saddleback Memorial Medical Center
Laguna Hills, California, 92653, United States
Long Beach Memorial Medical Center
Long Beach, California, 90806, United States
University of Southern California
Los Angeles, California, 90033, United States
Cedars-Sinai Medical Center/PRCC Cardiology Research
Los Angeles, California, 90048, United States
Memorial Medical Center (Sutter Gould Medical Foundation)
Modesto, California, 95355, United States
Sutter Medical Center Sacramento
Sacramento, California, 95819-3226, United States
Mercy General Hospital
Sacramento, California, 95819, United States
California Medical Center
San Francisco, California, 94120, United States
Stanford University Medical Center
Stanford, California, 94305, United States
St Joseph's Medical Center
Stockton, California, 95204, United States
Los Robles Hospital and Medical Center
Thousand Oaks, California, 91360, United States
Torrance Memorial Medical Center
Torrance, California, 90505, United States
Denver Health Medical Center
Denver, Colorado, 80204, United States
Centura Research Center
Denver, Colorado, 80210, United States
Bridgeport Hospital
Bridgeport, Connecticut, 06610, United States
St Francis Hospital and Medical Center
Hartford, Connecticut, 06105, United States
Yale University School of Medicine
New Haven, Connecticut, 06510, United States
Hospital of St. Raphael
New Haven, Connecticut, 06511, United States
Citrus Memorial Health Systems
Inverness, Florida, 34452, United States
Baptist Cardiac & Vascular Institute, Baptist Hospital of Miami
Miami, Florida, 33176, United States
Orlando Health
Orlando, Florida, 32806, United States
Pepin Heart Research Institute
Tampa, Florida, 33613, United States
St Elizabeth's Hospital
Belleville, Illinois, 62220, United States
Mercy Hospital and Medical Center
Chicago, Illinois, 60616, United States
University of Chicago Medical Center
Chicago, Illinois, 60637, United States
Northshore University Health System
Evanston, Illinois, 60201, United States
Memorial Health System
Springfield, Illinois, 62781, United States
Parkview Hospital
Fort Wayne, Indiana, 46805, United States
Krannert Heart Institute - Indiana University - Clarian Methodist Hospital
Indianapolis, Indiana, 46202, United States
The Indiana Heart Hospital
Indianapolis, Indiana, 46250, United States
St Vincent Hospital & Health Services
Indianapolis, Indiana, 46260, United States
Genesis Medical Center
Davenport, Iowa, 52803, United States
University of Iowa Hospitals and Clinics
Iowa City, Iowa, 54424, United States
Cotton-O'Neil Clinical Research Center
Topeka, Kansas, 66604, United States
Cardiovascular Research Foundation of Louisiana
Baton Rouge, Louisiana, 70808, United States
Central Maine Heart and Vascular Institute
Lewiston, Maine, 04240, United States
Boston Medical Center
Boston, Massachusetts, 02118, United States
Beth Israel Deaconess Medical Center
Boston, Massachusetts, 02215, United States
Oakwood Hospital and Medical Center
Dearborn, Michigan, 48123, United States
Henry Ford Hospital
Detroit, Michigan, 48202, United States
St John Hospital & Medical Center
Detroit, Michigan, 48236, United States
Spectrum Health
Grand Rapids, Michigan, 49503-2528, United States
Sparrow Hospital
Lansing, Michigan, 48909-7980, United States
Mount Clemens Regional Medical Center
Mount Clemens, Michigan, 48043, United States
Munson Medical Center
Traverse City, Michigan, 49684, United States
Minneapolis Heart Institute
Minneapolis, Minnesota, 55407, United States
St John's Regional Medical Center
Joplin, Missouri, 64804-1694, United States
Mid-America Heart Institute, St Luke's Hospital
Kansas City, Missouri, 64111, United States
Heartland Cardiovascular Consultants
Saint Joseph, Missouri, 64506, United States
Cox South Hospital
Springfield, Missouri, 65804, United States
St John's Medical Research Institute
Springfield, Missouri, 65807, United States
Washington University School of Medicine
St Louis, Missouri, 63110, United States
Bozeman Deaconess Hospital
Bozeman, Montana, 59715, United States
Glacier View Cardiology
Kalispell, Montana, 59901, United States
The International Heart Institute of Montana
Missoula, Montana, 59802, United States
Good Samaritan Hospital
Kearney, Nebraska, 68848, United States
BryanLGH Heart Institute
Lincoln, Nebraska, 68506, United States
The Valley Hospital
Ridgewood, New Jersey, 07450, United States
Overlook Hospital
Summit, New Jersey, 07929-0220, United States
Presbyterian Heart Group
Albuquerque, New Mexico, 87106, United States
Erie County Medical Center
Buffalo, New York, 14215, United States
Winthrop University Hospital
Mineola, New York, 11501, United States
Stony Brook University Medical Center
Stony Brook, New York, 11794-8167, United States
Jacobi Medical Center
The Bronx, New York, 10461, United States
Montefiore/Albert Einstein Medical Center
The Bronx, New York, 10461, United States
University of North Carolina at Chapel Hill
Chapel Hill, North Carolina, 27599-7075, United States
Presbyterian Hospital - Mid Carolina Cardiology
Charlotte, North Carolina, 28204, United States
Presbysterian Hospital - Mid Carolina Cardiology
Charlotte, North Carolina, 78704, United States
Forsyth Medical Center
Winston-Salem, North Carolina, 27103, United States
Summa Health System (Akron City Hospital)
Akron, Ohio, 44309, United States
The Ohio State University Medical Center
Columbus, Ohio, 43210, United States
St Rita's Medical Center
Lima, Ohio, 45801, United States
Heart Institute of the Cascades
Bend, Oregon, 97701-6015, United States
Samaritan Heart & Vascular Institute
Corvallis, Oregon, 97330, United States
Butler Memorial Hospital
Butler, Pennsylvania, 16001, United States
Geisinger Clinic - Cardiology
Danville, Pennsylvania, 17822-2160, United States
Hamot Medical Center
Erie, Pennsylvania, 16550-0001, United States
Pinnacle Health System
Harrisburg, Pennsylvania, 17101, United States
Allegheny General Hospital
Pittsburgh, Pennsylvania, 15212, United States
D. Guthrie Foundation for Education & Research
Sayre, Pennsylvania, 18840, United States
Sharon Regional Health System
Sharon, Pennsylvania, 16146, United States
Rhode Island Hospital
Providence, Rhode Island, 02903, United States
Baylor Research Institute
Dallas, Texas, 75226, United States
University of Texas Southwestern Medical Center at Dallas (UTSW)
Dallas, Texas, 75390-9034, United States
Fletcher Allen Health Care
Burlington, Vermont, 05401, United States
Sentara Hospital
Norfolk, Virginia, 23507, United States
Virginia Commonwealth University
Richmond, Virginia, 23298, United States
St Mary's Medical Center
Huntington, West Virginia, 25702, United States
Waukesha Memorial Hospital
Waukesha, Wisconsin, 53188, United States
Related Publications (8)
Sawano M, Lu Y, Caraballo C, Mahajan S, Dreyer R, Lichtman JH, D'Onofrio G, Spatz E, Khera R, Onuma O, Murugiah K, Spertus JA, Krumholz HM. Sex Difference in Outcomes of Acute Myocardial Infarction in Young Patients. J Am Coll Cardiol. 2023 May 9;81(18):1797-1806. doi: 10.1016/j.jacc.2023.03.383.
PMID: 37137590DERIVEDDing Q, Spatz ES, Lipska KJ, Lin H, Spertus JA, Dreyer RP, Whittemore R, Funk M, Bueno H, Krumholz HM. Newly diagnosed diabetes and outcomes after acute myocardial infarction in young adults. Heart. 2021 Apr;107(8):657-666. doi: 10.1136/heartjnl-2020-317101. Epub 2020 Oct 20.
PMID: 33082173DERIVEDDing Q, Funk M, Spatz ES, Whittemore R, Lin H, Lipska KJ, Dreyer RP, Spertus JA, Krumholz HM. Association of Diabetes Mellitus With Health Status Outcomes in Young Women and Men After Acute Myocardial Infarction: Results From the VIRGO Study. J Am Heart Assoc. 2019 Sep 3;8(17):e010988. doi: 10.1161/JAHA.118.010988. Epub 2019 Aug 23.
PMID: 31441351DERIVEDKhera AV, Chaffin M, Zekavat SM, Collins RL, Roselli C, Natarajan P, Lichtman JH, D'Onofrio G, Mattera J, Dreyer R, Spertus JA, Taylor KD, Psaty BM, Rich SS, Post W, Gupta N, Gabriel S, Lander E, Ida Chen YD, Talkowski ME, Rotter JI, Krumholz HM, Kathiresan S. Whole-Genome Sequencing to Characterize Monogenic and Polygenic Contributions in Patients Hospitalized With Early-Onset Myocardial Infarction. Circulation. 2019 Mar 26;139(13):1593-1602. doi: 10.1161/CIRCULATIONAHA.118.035658.
PMID: 30586733DERIVEDSafdar B, Spatz ES, Dreyer RP, Beltrame JF, Lichtman JH, Spertus JA, Reynolds HR, Geda M, Bueno H, Dziura JD, Krumholz HM, D'Onofrio G. Presentation, Clinical Profile, and Prognosis of Young Patients With Myocardial Infarction With Nonobstructive Coronary Arteries (MINOCA): Results From the VIRGO Study. J Am Heart Assoc. 2018 Jun 28;7(13):e009174. doi: 10.1161/JAHA.118.009174.
PMID: 29954744DERIVEDLu Y, Ding Q, Xu X, Spatz ES, Dreyer RP, D'Onofrio G, Caulfield M, Nasir K, Spertus JA, Krumholz HM. Sex Differences in Omega-3 and -6 Fatty Acids and Health Status Among Young Adults With Acute Myocardial Infarction: Results From the VIRGO Study. J Am Heart Assoc. 2018 May 30;7(11):e008189. doi: 10.1161/JAHA.117.008189.
PMID: 29848494DERIVEDLu Y, Zhou S, Dreyer RP, Spatz ES, Geda M, Lorenze NP, D'Onofrio G, Lichtman JH, Spertus JA, Ridker PM, Krumholz HM. Sex Differences in Inflammatory Markers and Health Status Among Young Adults With Acute Myocardial Infarction: Results From the VIRGO (Variation in Recovery: Role of Gender on Outcomes of Young Acute Myocardial Infarction Patients) Study. Circ Cardiovasc Qual Outcomes. 2017 Feb;10(2):e003470. doi: 10.1161/CIRCOUTCOMES.116.003470. Epub 2017 Feb 22.
PMID: 28228461DERIVEDLindau ST, Abramsohn EM, Bueno H, D'Onofrio G, Lichtman JH, Lorenze NP, Mehta Sanghani R, Spatz ES, Spertus JA, Strait K, Wroblewski K, Zhou S, Krumholz HM. Sexual activity and counseling in the first month after acute myocardial infarction among younger adults in the United States and Spain: a prospective, observational study. Circulation. 2014 Dec 23;130(25):2302-9. doi: 10.1161/CIRCULATIONAHA.114.012709. Epub 2014 Dec 15.
PMID: 25512442DERIVED
Biospecimen
Blood specimens for biomarker analysis and storage for future genetic studies
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Harlan M. Krumholz, MD, SM
Yale University
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
January 9, 2008
First Posted
January 18, 2008
Study Start
September 1, 2007
Primary Completion
February 1, 2013
Study Completion
February 1, 2013
Last Updated
March 30, 2020
Record last verified: 2014-06