Determining the Association of Chromosomal Variants With Non-PV Triggers and Ablation-outcome in AF (DECAF)
DECAF
1 other identifier
observational
400
1 country
2
Brief Summary
This prospective study aims to examine the association of specific genetic variants (single nucleotide polymorphisms) located on chromosome 1, 4 and 16, with presence of non-pulmonary vein triggers (NPVT) as well as ablation-outcome in AF patients
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Dec 2012
2 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
December 1, 2012
CompletedFirst Submitted
Initial submission to the registry
December 11, 2012
CompletedFirst Posted
Study publicly available on registry
December 18, 2012
CompletedPrimary Completion
Last participant's last visit for primary outcome
August 1, 2013
CompletedStudy Completion
Last participant's last visit for all outcomes
August 1, 2014
CompletedSeptember 5, 2014
September 1, 2014
8 months
December 11, 2012
September 4, 2014
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
PVAI and isolation of all non-PV triggers
Isolation of pulmonary-vein antra and all extra-pulmonary vein triggers
1 hour of the ablation procedure
Secondary Outcomes (1)
Recurrence of arrhythmia
Within 1 year of follow-up
Study Arms (1)
genetic variants
AFib patients with or without the genetic variants
Eligibility Criteria
patients with atrial fibrillation
You may qualify if:
- Age ≥ 18 years
- AF patients undergoing catheter ablation
- Able and willing to provide written informed consent
You may not qualify if:
- Previous left atrial catheter ablation or MAZE procedure
- Reversible causes of atrial arrhythmia such as hyperthyroidism, sarcoidosis, pulmonary embolism etc
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (2)
Texas Cardiac Arrhythmia Institute, St. david's Medical Center
Austin, Texas, 78705, United States
Texas Cardiac arrhythmia Institute, St. David's Hospital
Austin, Texas, United States
Related Publications (1)
Mohanty S, Hall AW, Mohanty P, Prakash S, Trivedi C, Di Biase L, Santangeli P, Bai R, Burkhardt JD, Gallinghouse GJ, Horton R, Sanchez JE, Hranitzky PM, Al-Ahmad A, Iyer VR, Natale A. Novel association of polymorphic genetic variants with predictors of outcome of catheter ablation in atrial fibrillation: new directions from a prospective study (DECAF). J Interv Card Electrophysiol. 2016 Jan;45(1):7-17. doi: 10.1007/s10840-015-0069-2.
PMID: 26497660DERIVED
Biospecimen
Blood samples will be collected from which DNA would be extracted for SNP analysis
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY DIRECTOR
Andrea Natale, MD
TCAI
- PRINCIPAL INVESTIGATOR
Mitra Mohanty, MD
TCAI
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Executive Medical Director
Study Record Dates
First Submitted
December 11, 2012
First Posted
December 18, 2012
Study Start
December 1, 2012
Primary Completion
August 1, 2013
Study Completion
August 1, 2014
Last Updated
September 5, 2014
Record last verified: 2014-09