Exosomal MicroRNA Expression in Children With Autism Spectrum Disorder

NCT01749670 | Completed

• 1 other identifier: 346301-1
• Study Type: observational
• Target: 45
• Locations: 1 country
• Sites: 1

Brief Summary

There is accumulating evidence that genetic expression plays a role in autism spectrum disorder, but the regulation of such genes is poorly understood. Small RNA particles, called microRNA (miRNA), have the ability to alter gene expression. These particles can be packaged and released from brain cells into the blood. Changes in miRNA may contribute to the patterns observed in autism spectrum disorder. The purpose of this study is to identify small RNA particles that regulate gene expression in autism spectrum disorder. The goal is to identify miRNA expression patterns which may improve our understanding and diagnosis of autism spectrum disorder.

Conditions

Autism Spectrum Disorder

Keywords

Autism Spectrum Disorder; Exosomal miRNA expression

Outcome Measures

Primary Outcomes (1)

• Exosomal microRNA expression patterns

  1 day

Study Arms (2)

Autism

Children ages 4-17 years old with DSM-IV defined autism spectrum disorder

Control

Age- and gender-matched controls with typical neuropsychological developmental patterns

Eligibility Criteria

• Age: 4 Years - 17 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17)
• Sampling Method: Non-Probability Sample

Study Population

Children from the University Pediatric and Adolescent Center and the Center for Development Behavior and Genetics in Syracuse, New York.

You may qualify if:

• Children ages 4-17

You may not qualify if:

• neurological impairments (i.e. cerebral palsy, epilepsy)
• sensory deficits (i.e. sensory or visual impairments)
• psychological disorders (i.e. obsessive compulsive disorder, attention deficit disorder)
• control subjects with family history of autism spectrum disorder
• mental retardation
• history of preterm birth

Sponsors & Collaborators

• State University of New York - Upstate Medical University: lead

Study Sites (1)

SUNY Upstate Medical University

Syracuse, New York, 13210, United States

Location

Biospecimen

Retention: SAMPLES WITH DNA

Whole Blood

MeSH Terms

Conditions

Autism Spectrum Disorder

Condition Hierarchy (Ancestors)

Child Development Disorders, Pervasive; Neurodevelopmental Disorders; Mental Disorders

Study Officials

• Steven Hicks, MD, PhD

  SUNY Upstate Medical University, Department of Pediatrics

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 12, 2012
• First Posted: December 17, 2012
• Study Start: January 1, 2013
• Primary Completion: September 1, 2014
• Study Completion: September 1, 2014
• Last Updated: November 26, 2014

Record last verified: 2014-11

Locations

US (1)