The Effect of Alcohol on Food Reward
The Effect of Moderate Alcohol Consumption on Subsequent Food Reward
1 other identifier
interventional
24
1 country
1
Brief Summary
Rationale It has been shown in several studies that alcohol increases subsequent food intake. However, moderate alcohol consumption has no clear effects on hunger and satiety hormones. In the Western world, where palatable food is highly available, food reward may play an important role in food intake. Alcohol consumption is known to stimulate neurotransmitters important for food reward and may therefore stimulate the reward response on a subsequent meal. This may lead to higher food consumption than when no alcohol is consumed. It is hypothesized that the reward response of food or beverages can already be generated when food or beverages are sensed in the mouth, because oral nutrient sensing is known to induce a satiety response (i.e. the cephalic phase response). Moreover, taste buds directly signal brain areas closely connected to the reward areas in the brain. Primary objective
- To determine whether moderate alcohol consumption influences subsequent food reward, as measured by questionnaires on food 'wanting' and food 'liking', and salivary and blood parameters related to reward. Secondary objectives
- To determine whether food reward is different when food is consumed than when food is sensed in the mouth, as measured by questionnaires on food 'wanting' and food 'liking', and salivary and blood parameters related to food reward.
- To determine whether moderate alcohol consumption influences subsequent food reward differently when food is consumed than when food is sensed in the mouth, as measured by questionnaires on food 'wanting' and food 'liking', and salivary and blood parameters related to food reward.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable obesity
Started Oct 2012
Shorter than P25 for not_applicable obesity
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
October 1, 2012
CompletedFirst Submitted
Initial submission to the registry
November 28, 2012
CompletedFirst Posted
Study publicly available on registry
November 30, 2012
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2012
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2012
CompletedJanuary 3, 2013
January 1, 2013
2 months
November 28, 2012
January 2, 2013
Conditions
Outcome Measures
Primary Outcomes (4)
Explicit food 'wanting'
Questionnaire measuring food 'wanting' explicitly with the question: "How much do you want to eat at this moment?" This is scored on a visual analogue scale ranging from 0-100.
up to 75 minutes
Implicit food 'wanting' for different food categories
Computer task measuring food 'wanting' implicitly for different food categories. This is a forced choice task in which subjects have to choose as quick and precise the food product they want to eat most at that moment.
up to 30 minutes
explicit food 'wanting' for different food categories
Questionnaire measuring food wanting explicitly for different food categories on a visual analogue scale (ranging 0-100).
up to 30 minutes
explicit food 'liking' for different food categories
Questionnaire measuring food 'liking' for different food categories on a visual analogue scale (ranging 0-100).
up to 30 minutes
Study Arms (6)
Alcohol placebo and MSF
EXPERIMENTAL175 mL orange juice with 31 g Fantomalt maltodextrin and modified sham feeding of 40 g butter cake
Alcohol and MSF
EXPERIMENTAL65 mL vodka with 135 mL orange juice (ca 20 g alcohol)and modified sham feeding of 40 g butter cake
Alcohol placebo and consumption
EXPERIMENTAL175 mL orange juice with 31 g maltodextrin and consumption of 40 g butter cake
Alcohol and consumption
EXPERIMENTAL65 mL vodka with 135 mL orange juice and consumption of 40 g butter cake
Alcohol placebo and control
EXPERIMENTAL175 mL orange juice with 31 g maltodextrin and no oral exposure to butter cake
Alcohol and control
EXPERIMENTAL65 mL vodka with 135 mL orange juice and no oral exposure to butter cake
Interventions
chewing on 40 gram cake for 6 minutes and before swallowing expectorating the bolus in cup.
chewing for 6 min on 40 gram cake and then swallow it.
Eligibility Criteria
You may qualify if:
- Caucasian men;
- Age 25-50 years on the day of the screening;
- Body Mass Index (BMI) of 20-25 kg/m2;
- Body weight of 60-100 kg;
- Able to read, write and fully understand the Dutch language, and
- Able to participate int he sudy, willing to give written informed consent and to comply with the study procedures and restrictions.
You may not qualify if:
- Above average score (\>2.26) on the restrained scale of the Dutch Eating Behaviour Questionnaire;
- Alcohol consumption \<6 and \>20 standard glasses/week;
- Not having regular and normal Dutch eating habits;
- Not having a normal day/night rhythm;
- Smoking, or stopped with smoking \<3 months prior to start of the study;
- Using drugs, or stopped using drugs \<3 months prior to start of the study;
- Having a (family) history of alcohol or drug related problems;
- Reported slimming or being on a medically described diet;
- Having a vegan, vegetarian or macrobiotic lifestyle;
- Loss of blood outside the limits of Sanquin within 3 months prior to screening;
- Participation in a clinical trial within 3 months prior to the start of this study or more than 4 times a year;
- Having a food allergy, sensitivity or disliking one of the foods used in the study;
- Reported unexplained weight loss or gain of \>4 kg in the month prior to the screening;
- Inappropriate veins for cannula insertion;
- Not having a general practitioner or health insurance;
- +2 more criteria
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Centre for Human Drug Research (CHDR)
Leiden, South Holland, 2333 CL, Netherlands
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Henk Hendriks, PhD
TNO Zeist, The Netherlands
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- PARTICIPANT
- Purpose
- BASIC SCIENCE
- Intervention Model
- CROSSOVER
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR INVESTIGATOR
- PI Title
- Project Manager
Study Record Dates
First Submitted
November 28, 2012
First Posted
November 30, 2012
Study Start
October 1, 2012
Primary Completion
December 1, 2012
Study Completion
December 1, 2012
Last Updated
January 3, 2013
Record last verified: 2013-01