A Low Glycemic Index Diet as Prevention of the Catch-up Fat Phenomenon

NCT01737034 | Completed

• 1 other identifier: BMBF 0315681
• Study Type: interventional
• Target: 32
• Locations: 1 country
• Sites: 1

Brief Summary

The catch-up fat phenomenon is an evolutionary conserved physiological response to a starvationrefeeding cycle. It is characterized by long-term suppression of thermogenesis, reduced body protein regain and an increase in fat mass above basal level during refeeding. Clinically, it characterises weight cycling in overweight patients which is associated with increasing fat mass (visceral fat) and increased morbidity (e.g. insulin resistance, inflammation). In this project, the physiological, cellular and molecular mechanisms of this phenomenon will be investigated in humans, mice and C. elegans. It is hypothesized that refeeding a low GI (=glycemic index)- diet after weight loss prevents the catchup fat phenomenon and its sequelae. This translational research will provide comprehensive insights into the catch-up fat phenomenon as well as provide a suitable strategy of its prevention.

Conditions

Dietary Intervention

Keywords

partitioning of weight gain; refeeding; catch-up fat phenomenon; glycemic index

Outcome Measures

Primary Outcomes (1)

• Changes in body composition and energy metabolism after 3 weeks of underfeeding and 2 following weeks of refeeding

  Body composition measurement including BODPOD, QMR, BIA Energy Metabolism measurement using indirect calorimetry

  Body composition measurement after 4 and 6 study weeks

Study Arms (4)

low GI, low GI

EXPERIMENTAL

low GI diet (semi starvation phase) followed by low GI diet in the refeeding phase

Other: dietary intervention by varying GI diets

low GI, high GI

EXPERIMENTAL

low GI diet (semi starvation phase) followed by high GI diet in the refeeding phase

Other: dietary intervention by varying GI diets

high GI, low GI

EXPERIMENTAL

high GI diet (semi starvation phase) followed by low GI diet in the refeeding phase

Other: dietary intervention by varying GI diets

high GI, high GI

EXPERIMENTAL

high GI diet (semi starvation phase) followed by high GI diet in the refeeding phase

Other: dietary intervention by varying GI diets

Interventions

dietary intervention by varying GI diets OTHER

The human study intends to characterise the partitioning of weight gain during refeeding and to affect the catch-up fat phenomenon by the glycemic index (GI) of the diet.

high GI, high GI; high GI, low GI; low GI, high GI; low GI, low GI

Eligibility Criteria

• Age: 20 Years - 40 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• normal weight (BMI 20-24 kg/m2), normal fat mass

You may not qualify if:

• smoking, chronic diseases, drug intake, nutrient allergies, lactose intolerance, pacemaker, metalliferous implants

Sponsors & Collaborators

• University of Kiel: lead

Study Sites (1)

Institute of Human Nutrition

Kiel, Schleswig-Holstein, 24105, Germany

Location

Related Publications (6)

• Breusing N, Lagerpusch M, Engstler AJ, Bergheim I, Mueller MJ, Bosy-Westphal A. Influence of Energy Balance and Glycemic Index on Metabolic Endotoxemia in Healthy Men. J Am Coll Nutr. 2017 Jan;36(1):72-79. doi: 10.1080/07315724.2016.1156036. Epub 2017 Jan 6.

  PMID: 28060600 DERIVED

• Geisler C, Braun W, Pourhassan M, Schweitzer L, Gluer CC, Bosy-Westphal A, Muller MJ. Gender-Specific Associations in Age-Related Changes in Resting Energy Expenditure (REE) and MRI Measured Body Composition in Healthy Caucasians. J Gerontol A Biol Sci Med Sci. 2016 Jul;71(7):941-6. doi: 10.1093/gerona/glv211. Epub 2015 Nov 20.

  PMID: 26590912 DERIVED

• Muller MJ, Enderle J, Pourhassan M, Braun W, Eggeling B, Lagerpusch M, Gluer CC, Kehayias JJ, Kiosz D, Bosy-Westphal A. Metabolic adaptation to caloric restriction and subsequent refeeding: the Minnesota Starvation Experiment revisited. Am J Clin Nutr. 2015 Oct;102(4):807-19. doi: 10.3945/ajcn.115.109173. Epub 2015 Sep 23.

  PMID: 26399868 DERIVED

• Schweitzer L, Geisler C, Pourhassan M, Braun W, Gluer CC, Bosy-Westphal A, Muller MJ. What is the best reference site for a single MRI slice to assess whole-body skeletal muscle and adipose tissue volumes in healthy adults? Am J Clin Nutr. 2015 Jul;102(1):58-65. doi: 10.3945/ajcn.115.111203. Epub 2015 May 27.

  PMID: 26016860 DERIVED

• Karschin J, Lagerpusch M, Enderle J, Eggeling B, Muller MJ, Bosy-Westphal A. Endocrine determinants of changes in insulin sensitivity and insulin secretion during a weight cycle in healthy men. PLoS One. 2015 Feb 27;10(2):e0117865. doi: 10.1371/journal.pone.0117865. eCollection 2015.

  PMID: 25723719 DERIVED

• Lagerpusch M, Enderle J, Eggeling B, Braun W, Johannsen M, Pape D, Muller MJ, Bosy-Westphal A. Carbohydrate quality and quantity affect glucose and lipid metabolism during weight regain in healthy men. J Nutr. 2013 Oct;143(10):1593-601. doi: 10.3945/jn.113.179390. Epub 2013 Aug 14.

  PMID: 23946346 DERIVED

Study Officials

• Manfred J. Müller, Prof.

  Institute of Human Nutrition, University of Kiel

  STUDY CHAIR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: November 26, 2012
• First Posted: November 29, 2012
• Study Start: January 1, 2011
• Primary Completion: August 1, 2012
• Study Completion: August 1, 2012
• Last Updated: November 30, 2012

Record last verified: 2012-11

Locations

DE (1)