Effects of Dietary Nitrate on Age-related Vascular Function
Effects of Dietary Nitrate Supplementation on Age-related Vascular Dysfunction
1 other identifier
interventional
20
1 country
1
Brief Summary
Purpose of the study is to characterize the chronic effect of dietary nitrate on vascular function in healthy volunteers with particular emphasis on age-related alterations.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for phase_1
Started Oct 2012
Shorter than P25 for phase_1
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
October 1, 2012
CompletedFirst Submitted
Initial submission to the registry
November 14, 2012
CompletedFirst Posted
Study publicly available on registry
November 20, 2012
CompletedPrimary Completion
Last participant's last visit for primary outcome
May 1, 2013
CompletedStudy Completion
Last participant's last visit for all outcomes
May 1, 2013
CompletedDecember 9, 2013
December 1, 2013
7 months
November 14, 2012
December 6, 2013
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Endothelial function measured by flow-mediated dilation (FMD)
The effect of dietary nitrate on endothelial function as measured by flow-mediated dilation (FMD) after forearm ischemia and reperfusion.
30 days
Study Arms (2)
Nitrate
EXPERIMENTAL150µmol /Kg bodyweight /day
PLacebo
PLACEBO COMPARATOR150µmol /Kg bodyweight /day
Interventions
Eligibility Criteria
You may qualify if:
- \>55 Years Healthy
You may not qualify if:
- known cardiovascular disease
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Heinrich-Heine-University
Düsseldorf, North Rhine-Westphalia, 40225, Germany
MeSH Terms
Interventions
Intervention Hierarchy (Ancestors)
Study Design
- Study Type
- interventional
- Phase
- phase 1
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- PARTICIPANT, INVESTIGATOR
- Purpose
- PREVENTION
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
November 14, 2012
First Posted
November 20, 2012
Study Start
October 1, 2012
Primary Completion
May 1, 2013
Study Completion
May 1, 2013
Last Updated
December 9, 2013
Record last verified: 2013-12