Satiety Effects on the Neural Valuation of Food

NCT01721187 | Completed

• 1 other identifier: VOFIO3G
• Study Type: observational
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

Using fMRI, this study will explore the neural correlates of satiety when individuals make decisions about food. The investigators will also examine individual differences in satiety effects.

Conditions

Fasting; Fed

Keywords

fMRI; Satiety; Willingness to Pay; Incentive Delay; Dietary Disinhibition

Outcome Measures

Primary Outcomes (2)

• fMRI - Willingness to Pay task (BDM auction)

  A measurement of how much participants are willing to pay for foods and non-foods, as an assay for subjective value of goods.

  Fed and fasted visits (Wks 1 & 2)

• fMRI - Monetary and Food Incentive Delay task

  A measurement of neural response to anticipating and receiving money and food rewards.

  Fed and fasted visits (Wks 1 & 2)

Study Arms (2)

Low disinhibition

fMRI during fed and fasted states

High disinhibition

fMRI during fed and fasted states

Eligibility Criteria

• Age: 21 Years - 45 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Community sample

You may qualify if:

• Chinese ethnicity
• to 45 years old
• English as first language
• Right-handed
• Have normal eyesight, or have long-sightedness or myopia within +8.0 to -8.0 diopters (unless corrected by contact lenses)
• Weigh less than 100kg with an abdominal circumference of less than 120cm
• Non-smoker, or only smoke occasionally (less than 5 sticks a week)
• Consume less than 2 units (200 mg) of caffeine a day
• Consume less than 21 units of alcohol per week (e.g. 500ml 5% beer = 2.5 units, 250ml 14% wine = 3.5 unit)
• Habitually sleep before 1am and wake before 9am

You may not qualify if:

• On a restrictive diet (e.g., vegetarian/vegan diet)
• History of food allergies
• History of psychiatric or neurological disorders
• History of chronic medical illness
• Metal implants in or on the body (e.g. braces, dental retainers, pacemakers)
• Shift worker
• Claustrophobic
• High astigmatism (high = \>2.00 diopters)
• Colour-blind

Sponsors & Collaborators

• Duke-NUS Graduate Medical School: lead
• Institute for Human Development and Potential (IHDP), Singapore: collaborator

Study Sites (1)

Centre for Cognitive Neuroscience scanner suite

Singapore, Singapore, 169611, Singapore

Location

Related Publications (2)

• Plassmann H, O'Doherty J, Rangel A. Orbitofrontal cortex encodes willingness to pay in everyday economic transactions. J Neurosci. 2007 Sep 12;27(37):9984-8. doi: 10.1523/JNEUROSCI.2131-07.2007.

  PMID: 17855612 BACKGROUND

• Knutson B, Westdorp A, Kaiser E, Hommer D. FMRI visualization of brain activity during a monetary incentive delay task. Neuroimage. 2000 Jul;12(1):20-7. doi: 10.1006/nimg.2000.0593.

  PMID: 10875899 BACKGROUND

Biospecimen

Retention: NONE RETAINED

(NA)

MeSH Terms

Conditions

Fasting; Lecithin Cholesterol Acyltransferase Deficiency

Condition Hierarchy (Ancestors)

Feeding Behavior; Behavior; Hypoalphalipoproteinemias; Hypolipoproteinemias; Lipid Metabolism, Inborn Errors; Metabolism, Inborn Errors; Genetic Diseases, Inborn; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Dyslipidemias; Lipid Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases

Study Officials

• Michael WL Chee, MBBS

  Duke-NUS Graduate Medical School

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: October 23, 2012
• First Posted: November 5, 2012
• Study Start: October 1, 2012
• Primary Completion: December 1, 2013
• Study Completion: July 1, 2014
• Last Updated: August 5, 2015

Record last verified: 2015-08

Locations

SG (1)