Beetroot Enriched Bread, Blood Pressure and Vascular Function
The Effects of Beetroot Enriched Bread on Postprandial Vascular Function, Arterial Stiffness and Blood Pressure in Healthy Men
2 other identifiers
interventional
24
1 country
1
Brief Summary
Dietary nitrate is known to lower blood pressure. Beetroot is a rich source of nitrate and could therefore be an important dietary component in the management of hypertension and cardiovascular disease, however consumption is relatively low. We evaluated the effects of beetroot enriched bread ingestion on acute microvascular reactivity, arterial stiffness and blood pressure response in healthy men.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable hypertension
Started Jun 2010
Shorter than P25 for not_applicable hypertension
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
June 1, 2010
CompletedPrimary Completion
Last participant's last visit for primary outcome
October 1, 2010
CompletedStudy Completion
Last participant's last visit for all outcomes
October 1, 2010
CompletedFirst Submitted
Initial submission to the registry
September 27, 2012
CompletedFirst Posted
Study publicly available on registry
October 15, 2012
CompletedOctober 15, 2012
October 1, 2012
4 months
September 27, 2012
October 12, 2012
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Vascular reactivity
Forearm blood flow by Laser Doppler Imaging with iontophoresis
Change from baseline at 2, 4 and 6 hours after bread consumption
Secondary Outcomes (4)
Arterial stiffness
Change from baseline at 2, 4 and 6 hours after bread consumption
Blood pressure
Change from baseline at 30 minute intervals for 7 hours
Plasma nitrate
Every 30 minutes for 7 hours
Plasma nitrite
Every 30 minutes for 7 hours
Study Arms (2)
Control white bread
PLACEBO COMPARATORBeetroot bread
EXPERIMENTALInterventions
Eligibility Criteria
You may qualify if:
- Male
- A signed consent form
- Age 18-64 years
- Body mass index - 18.5-30 kg/m2
- Non-smoking, healthy individuals
- Normal blood pressure at screening (\< 150/90)
You may not qualify if:
- Subjects with anaemia
- Sufferers of chronic illnesses
- Individuals with food allergies
- People with diabetes
- People with coeliac disease
- Women
- Vegetarians
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
University of Reading
Reading, Berkshire, RG6 6AP, United Kingdom
Related Publications (2)
Hobbs DA, Kaffa N, George TW, Methven L, Lovegrove JA. Blood pressure-lowering effects of beetroot juice and novel beetroot-enriched bread products in normotensive male subjects. Br J Nutr. 2012 Dec 14;108(11):2066-74. doi: 10.1017/S0007114512000190. Epub 2012 Mar 14.
PMID: 22414688BACKGROUNDHobbs DA, Goulding MG, Nguyen A, Malaver T, Walker CF, George TW, Methven L, Lovegrove JA. Acute ingestion of beetroot bread increases endothelium-independent vasodilation and lowers diastolic blood pressure in healthy men: a randomized controlled trial. J Nutr. 2013 Sep;143(9):1399-405. doi: 10.3945/jn.113.175778. Epub 2013 Jul 24.
PMID: 23884387DERIVED
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- PARTICIPANT
- Purpose
- PREVENTION
- Intervention Model
- CROSSOVER
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Professor
Study Record Dates
First Submitted
September 27, 2012
First Posted
October 15, 2012
Study Start
June 1, 2010
Primary Completion
October 1, 2010
Study Completion
October 1, 2010
Last Updated
October 15, 2012
Record last verified: 2012-10