NCT01688622

Brief Summary

Glypican4, CTRP3, CTRP5 are emerging novel adipokines mediating obesity and inflammation related disorders. RBP4 and adiponectin are well known important adipokines. Therefore, we examine the circulating levels of theses adipokines in the subjects with or without metabolic syndrome. Furthermore, we tried to clarify the effect of exercise on the circulating these adipokines.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
90

participants targeted

Target at P50-P75 for not_applicable

Timeline
Completed

Started Jul 2012

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

July 1, 2012

Completed
2 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

September 1, 2012

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

September 1, 2012

Completed
12 days until next milestone

First Submitted

Initial submission to the registry

September 13, 2012

Completed
7 days until next milestone

First Posted

Study publicly available on registry

September 20, 2012

Completed
Last Updated

September 21, 2012

Status Verified

September 1, 2012

Enrollment Period

2 months

First QC Date

September 13, 2012

Last Update Submit

September 20, 2012

Conditions

Metabolic SyndromeObesity

Outcome Measures

Primary Outcomes (5)

  • The changes of circulating glypican4 levels after 3 months exercise

    baseline and 12weeks

  • The changes of circulating CTRP3 levels after 3 months exercise

    baseline and 12weeks

  • The changes of circulating CTRP5 levels after 3 months exercise

    baseline and 12weeks

  • The changes of circulating RBP4 levels after 3 months exercise

    baseline and 12weeks

  • The changes of circulating adiponectin levels after 3 months exercise

    baseline and 12weeks

Secondary Outcomes (5)

  • Circulating glypican4 levels in the subjects with or without metabolic syndrome

    baseline

  • Circulating CTRP3 levels in the subjects with or without metabolic syndrome

    baseline

  • Circulating CTRP5 levels in the subjects with or without metabolic syndrome

    baseline

  • Circulating RBP4 levels in the subjects with or without metabolic syndrome

    baseline

  • Circulating adiponectin levels in the subjects with or without metabolic syndrome

    baseline

Study Arms (1)

Exercise

OTHER

obese women who are volunteers for the 3 months exercise programs

Behavioral: 3months Exercise

Interventions

3months ExerciseBEHAVIORAL

training session consisting of a brief warm-up, followed by an approximately 45-min session of aerobic exercise at an intensity of 60-75% of the age-predicted maximum heart rate (approximately 300 kcal/day) and a 20-min muscle strength train- ing programme (approximately 100 kcal/day), followed by a brief cool-down period.

Exercise

Eligibility Criteria

Age20 Years - 80 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Women between 30 and 60 years of age who had a body mass index (BMI) more than 25 kg/m2
  • The subjects of metabolic syndrome and age, gender matched non metabolic syndrome among the participants of Korean SO Study (KSOS) study, which is an ongoing epidemiologic study supported by the Korea Science and Engineering Foundation

You may not qualify if:

  • participants had a history of cardiovascular disease
  • any type of diabetes
  • stage 2 hypertension
  • malignant disease, severe renal, or hepatic disease
  • Subjects taking medications that might affect body weight or body composition

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Korea University Guro Hospital

Seoul, South Korea

Location

Related Publications (2)

  • Choi HY, Park JW, Lee N, Hwang SY, Cho GJ, Hong HC, Yoo HJ, Hwang TG, Kim SM, Baik SH, Park KS, Youn BS, Choi KM. Effects of a combined aerobic and resistance exercise program on C1q/TNF-related protein-3 (CTRP-3) and CTRP-5 levels. Diabetes Care. 2013 Oct;36(10):3321-7. doi: 10.2337/dc13-0178. Epub 2013 Jun 18.

    PMID: 23780948DERIVED

  • Yoo HJ, Hwang SY, Cho GJ, Hong HC, Choi HY, Hwang TG, Kim SM, Bluher M, Youn BS, Baik SH, Choi KM. Association of glypican-4 with body fat distribution, insulin resistance, and nonalcoholic fatty liver disease. J Clin Endocrinol Metab. 2013 Jul;98(7):2897-901. doi: 10.1210/jc.2012-4297. Epub 2013 Apr 30.

    PMID: 23633195DERIVED

MeSH Terms

Conditions

Metabolic SyndromeObesity

Interventions

Exercise

Condition Hierarchy (Ancestors)

Insulin ResistanceHyperinsulinismGlucose Metabolism DisordersMetabolic DiseasesNutritional and Metabolic DiseasesOverweightOvernutritionNutrition DisordersBody WeightSigns and SymptomsPathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Motor ActivityMovementMusculoskeletal Physiological PhenomenaMusculoskeletal and Neural Physiological Phenomena

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NA
Masking
NONE
Intervention Model
SINGLE GROUP
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Professor

Study Record Dates

First Submitted

September 13, 2012

First Posted

September 20, 2012

Study Start

July 1, 2012

Primary Completion

September 1, 2012

Study Completion

September 1, 2012

Last Updated

September 21, 2012

Record last verified: 2012-09

Locations

KR(1)