The Prevalence and Impact of Depression and Anxiety Symptoms in Patients With Non-CF Bronchiectasis

NCT01688180 | Unknown DMC

• 1 other identifier: Yonghua Gao
• Study Type: observational
• Target: 160
• Locations: 1 country
• Sites: 1

Brief Summary

Patients with chronic diseases are at great risk of depression and anxiety.It is known that depression and anxiety are one of the most common comorbidities associated with chronic lung diseases such as asthma and chronic obstructive pulmonary disease. However,to date,little is known about the rates and risk factors of depression and anxiety symptoms in non-CF bronchiectasis;and no large-scale prospective studies have been performed to investigate the effect of depression and anxiety on the healthy outcomes(such as number of exacerbations and hospitalizations over the ensuing year).Our purpose is to fill these gaps.

Conditions

Bronchiectasis

Keywords

bronchiectasis; depression; anxiety

Outcome Measures

Primary Outcomes (1)

• To evaluate the impact of depression and anxiety symptoms on non-CF bronchiectasis health outcomes.

  Depression and anxiety are assessed at baseline using the Hospital Anxiety and Depression Scale(HADS).Health-related quality of life(HRQL) is measured using St.George's Respiratory Questionnaire(SGRQ), Leicester cough questionnaire(LCQ) and COPD assessment test(CAT) at baseline and follow-up.In the ensuing year,patients are monitored monthly by telephnone for 12 months to document the occurrence and characteristics of non-CF bronchiectasis exacerbations and hospitalizations.Patients are also encouraged to report to their investigators and research nurses whenever they experience symptom worsening.An exacerbation was defined as persistent (\>24 hour) deterioration in at least three respiratory symptoms (including cough,dyspnoea, haemoptysis, increased sputum purulence or volume, and chest pain), with or without fever (\>37.5˚ C),radiographic deterioration, systemic disturbances, or deterioration in chest signs.

  one year

Secondary Outcomes (1)

• To estimate the prevalence of anxiety and depression symptoms in patients with non-CF bronchiectasis

  six months

Other Outcomes (1)

• To identify risk factors associated with symptoms of depression and anxiety in patients with non-CF bronchiectasis

  six months

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Adults with non-CF bronchiectasis attending the First Affiliated Hospital of Guangzhou Medical College,Guangzhou,Guangdong,China

You may qualify if:

• Age ≥18 years
• HRCT diagnosed Bronchiectasis
• No fever,no worsening of respiratory symptoms,and no medication change within the 4 weeks before recruitment.
• Capable of providing written informed consent

You may not qualify if:

• cystic fibrosis
• Previous lung transplantation

Sponsors & Collaborators

• The First Affiliated Hospital of Guangzhou Medical University: lead

Study Sites (1)

The First Affiliated Hospital of Guangzhou Medical University

Guangzhou, Guangdong, 510000, China

RECRUITING

Related Publications (1)

• Gao YH, Guan WJ, Xu G, Gao Y, Lin ZY, Tang Y, Lin ZM, Li HM, Luo Q, Zhong NS, Birring SS, Chen RC. Validation of the Mandarin Chinese version of the Leicester Cough Questionnaire in bronchiectasis. Int J Tuberc Lung Dis. 2014 Dec;18(12):1431-7. doi: 10.5588/ijtld.14.0195.

  PMID: 25517807 DERIVED

MeSH Terms

Conditions

Bronchiectasis; Depression; Anxiety Disorders

Condition Hierarchy (Ancestors)

Bronchial Diseases; Respiratory Tract Diseases; Behavioral Symptoms; Behavior; Mental Disorders

Study Officials

• Yongchang Chen, professor

  The First Affiliated Hospital of Guangzhou Medical University

  STUDY DIRECTOR

• Nanshan Zhong, Professor

  The First Affiliated Hospital of Guangzhou Medical University

  STUDY CHAIR

Central Study Contacts

yonghua gao, PHD

CONTACT

008615836704735; gaoyonghuahust@163.com

gang xu, PHD

CONTACT

008613580375817; 158572962@qq.com

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: PHD

Study Record Dates

• First Submitted: September 14, 2012
• First Posted: September 19, 2012
• Study Start: December 1, 2012
• Primary Completion: May 1, 2014
• Study Completion: May 1, 2014
• Last Updated: August 7, 2013

Record last verified: 2013-08

Locations

CN (1)