NCT01678274|Unknown
Prospective Characterization of the Heart, Aorta and Blood Pressure in Turner Syndrome. Association With Aortic Dissection.
TSCORII
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TSCORII
Sponsor study identifier
observational
106
1 country
1
Study Start
December 2013
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
March 2016
Actual (reported)Study Completion
October 2016
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Turner syndrome is a congenital complete or partial lack one of the female sex chromosomes affecting 1 of 2000 live born girls. The syndrome is characterized by an increased prevalence of ischemic heart disease, aortic dilation and dissection, hypertension, stroke and autoimmune diseases in general. Our study aim is:
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
October 2016
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
August 30, 2012
Actual (reported)September 3, 2012
Actual (reported)December 2013
Date type not reportedThis date has not been verified as actual or estimated.
March 2016
Actual (reported)October 2016
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Aortic dimensions
Aortic dimensions measured by MRI
Once
Agatston score
Coronary CT evaluation of Agatston score
Once
Segment involvement score
Segment involvement score (SIS) calculated as the sum of segments with one or more coronary plaques (score 0-18).
Once
Aortic distensibility
Females with Turner syndrome
age matched females acting as controls
Females with Turner Syndrome previously participating in our study number 2001024 are recruited from out-patient clinics. Controls are healthy volunteers recruited from the general population by advertisement.
Department of Endocrinology and Internal medicine
Aarhus, 8000, Denmark
Ridder LO, Stochholm K, Mortensen KH, Andersen NH, Gravholt CH. The TGFbeta system and TIMP1 and 3 genotypes in Turner syndrome-Relation with aortic congenital malformations. Clin Endocrinol (Oxf). 2023 Dec;99(6):545-551. doi: 10.1111/cen.14907. Epub 2023 Mar 15.
Viuff MH, Just J, Brun S, Dam TV, Hansen M, Melgaard L, Hougaard DM, Lappe M, Gravholt CH. Women With Turner Syndrome Are Both Estrogen and Androgen Deficient: The Impact of Hormone Replacement Therapy. J Clin Endocrinol Metab. 2022 Jun 16;107(7):1983-1993. doi: 10.1210/clinem/dgac167.
Blood Serum
Claus H Gravholt, MD
Aarhus University Hospital
Christian Trolle, MD
Aarhus University Hospital
106 participants (actual enrollment reported by the registry).
First Submitted
August 30, 2012
First Posted
September 3, 2012
Study Start
December 2013
Date type not reportedThis date has not been verified as actual or estimated.
Dan-NICAD - Danish Study of Non-Invasive Diagnostic Testing in Coronary Artery Disease
Aortic distensibillity as measured by MRI
Once
24 hour blood pressure
24 hour
Pulse Wave Velocity
Once
Augmentation index
Once
Central blood pressure
Once
echocardiography
Once
Contact the study team to confirm eligibility.
Wen J, Trolle C, Viuff MH, Ringgaard S, Laugesen E, Gutmark EJ, Subramaniam DR, Backeljauw P, Gutmark-Little I, Andersen NH, Mortensen KH, Gravholt CH. Impaired aortic distensibility and elevated central blood pressure in Turner Syndrome: a cardiovascular magnetic resonance study. J Cardiovasc Magn Reson. 2018 Dec 13;20(1):80. doi: 10.1186/s12968-018-0497-0.
Subramaniam DR, Stoddard WA, Mortensen KH, Ringgaard S, Trolle C, Gravholt CH, Gutmark EJ, Mylavarapu G, Backeljauw PF, Gutmark-Little I. Continuous measurement of aortic dimensions in Turner syndrome: a cardiovascular magnetic resonance study. J Cardiovasc Magn Reson. 2017 Feb 24;19(1):20. doi: 10.1186/s12968-017-0336-8.
Primary Completion
March 2016
Actual (reported)Study Completion
October 2016
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Last Updated
May 24, 2016
Record last verified: 2015-06
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