NCT01678222|Completed
The COX-2 Gene and the Immune System
The Role of Functionally Relevant Cyclooxygenase-2 (COX-2) Gene Single Nucleotide Polymorphisms - 765G>C and 8473T>C in Lymphocyte Differentiation
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The Role of Functionally Relevant Cyclooxygenase-2 (COX-2) Gene Single Nucleotide Polymorphisms - 765G>C and 8473T>C in Lymphocyte Differentiation
Sponsor study identifier
Secondary identifiers
observational
117
1 country
1
Study Start
May 2, 2013
Actual (reported)Primary Completion
Not reported
Date not reportedStudy Completion
Not reported
Date not reportedBackground: \- The immune system contains several different types of cells in the blood and other parts of the body. The body can fight infections well with the right balance of these cell types. The wrong balance of cell types may cause diseases, such as allergies or asthma. The COX-2 gene may help decide the balance of cell types that the body makes as part of the immune system. It may also play a role in certain immune system diseases. Researchers want to see how COX-2 affects the cells in the immune system. Objectives: \- To study how the COX-2 gene works in the body s immune system. Eligibility: \- Individuals 18 years of age and above who are part of the Environmental Polymorphisms Registry. Design:
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
Not reported
Date not reportedClick on a node to explore related trials.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
August 30, 2012
Actual (reported)September 3, 2012
Actual (reported)May 2, 2013
Actual (reported)To determine whether 765>C is associated with altered Th2, Th9, and Th17 differentiation in vivo
To determine whether 765\>C is associated with altered Th2, Th9, and Th17 differentiation in vivo
Ongoing
To determine whether 8473T>C is associated with altered Th2, Th9, and Th17 differentiation in vivo
To determine whether 8473T\>C is associated with altered Th2, Th9, and Th17 differentiation in vivo
Ongoing
individuals who are homozygous for either the major or minor variant of both SNPs
individuals who are homozygous for either the major or minor variant of both SNPs@@@
NIEHS Clinical Research Unit (CRU)
Research Triangle Park, North Carolina, United States
Li H, Bradbury JA, Dackor RT, Edin ML, Graves JP, DeGraff LM, Wang PM, Bortner CD, Maruoka S, Lih FB, Cook DN, Tomer KB, Jetten AM, Zeldin DC. Cyclooxygenase-2 regulates Th17 cell differentiation during allergic lung inflammation. Am J Respir Crit Care Med. 2011 Jul 1;184(1):37-49. doi: 10.1164/rccm.201010-1637OC. Epub 2011 Apr 7.
McAdam BF, Catella-Lawson F, Mardini IA, Kapoor S, Lawson JA, FitzGerald GA. Systemic biosynthesis of prostacyclin by cyclooxygenase (COX)-2: the human pharmacology of a selective inhibitor of COX-2. Proc Natl Acad Sci U S A. 1999 Jan 5;96(1):272-7. doi: 10.1073/pnas.96.1.272.
Darryl C Zeldin, M.D.
National Institute of Environmental Health Sciences (NIEHS)
117 participants (actual enrollment reported by the registry).
First Submitted
August 30, 2012
First Posted
September 3, 2012
Study Start
May 2, 2013
Actual (reported)Asthma Express: Bridging the Emergency to Primary Care in Underserved Children
Contact the study team to confirm eligibility.
Mai J, Wang H, Yang XF. Th 17 cells interplay with Foxp3+ Tregs in regulation of inflammation and autoimmunity. Front Biosci (Landmark Ed). 2010 Jun 1;15(3):986-1006. doi: 10.2741/3657.
Last Updated
October 16, 2026
Record last verified: 2026-08-28
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