A Population-based Study of Macular Choroidal Neovascularization in a Chinese Population

NCT01666821 | Completed DMC

• 1 other identifier: 04-E-1
• Study Type: observational
• Target: 59
• Locations: 1 country
• Sites: 1

Brief Summary

To investigate pathomorphological and functional variations of choroidal neovascularization (CNV) in age-related macular degeneration (AMD) in a Chinese population using optical coherence tomography (OCT) to find which kinds of Fundus characteristics indicated exudative AMD.

Conditions

Geographic Atrophy; Wet Macular Degeneration; Retinal Drusen

Keywords

macular degeneration; choroidal neovascularization

Outcome Measures

Primary Outcomes (1)

• change of the early and intermediate-stage AMD

  Drusen with unclear boundaries and obvious pigment proliferation, with hypofluorescence around drusens seen on FFA and a slight small arch field located in the retinal pigment epithelium (RPE)/choriocapillary layer (CCL) on OCT indicated exudative AMD.

  May 2004-September 2008

Study Arms (1)

early and intermediate-stage AMD

Follow-up observation was implemented in whose fundus examination show lesions in the early and intermediate-stage AMD

Other: Follow-up observation

Interventions

Follow-up observation OTHER

a epidemiologic survey of ocular diseases in an adult population (\>45 years old) in Youyi Street, Baoshan District, Shanghai, China, conducted to determine the prevalence of AMD in the region. To this end, we utilized routine ocular examinations

early and intermediate-stage AMD

Eligibility Criteria

• Age: 45 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

recruited 1813 adults citizens aged above 45 years by probability sampling from the Youyi Street, Baoshan District, Shanghai, China for an epidemiologic survey. All participants gave written informed consent, and this study was approved by the local Ethics Committee in accordance with the Helsinki Declaration.

You may qualify if:

• adults citizens aged above 45 years

You may not qualify if:

• lost samples

Sponsors & Collaborators

• Shanghai University of Traditional Chinese Medicine: lead

Study Sites (1)

Youyi Street

Shanghai, Baoshan District, 201900, China

Location

MeSH Terms

Conditions

Geographic Atrophy; Wet Macular Degeneration; Retinal Drusen; Choroidal Neovascularization

Condition Hierarchy (Ancestors)

Macular Degeneration; Retinal Degeneration; Retinal Diseases; Eye Diseases; Choroid Diseases; Uveal Diseases; Neovascularization, Pathologic; Metaplasia; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• zhao jie, master

  Director of ophthalmology

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: ECOLOGIC OR COMMUNITY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Department of ophthalmology, Shuguang hospital(Baoshan branch),Shanghai University of TCM

Study Record Dates

• First Submitted: August 14, 2012
• First Posted: August 16, 2012
• Study Start: May 1, 2004
• Primary Completion: September 1, 2008
• Study Completion: January 1, 2009
• Last Updated: August 16, 2012

Record last verified: 2012-08

Locations

CN (1)