NCT01663883|CompletedDMC
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Sponsor study identifier
interventional
40
1 country
1
Study Start
February 2012
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
April 2012
Actual (reported)Study Completion
August 2012
Actual (reported)Constant despite changes in perfusion pressure. It is observed in many vascular beds of the human body to prevent that variations in perfusion pressure are directly transmitted into changes in blood flow. This is necessary to prevent ischemia and/or hypoxia during decreased blood flow and bleeding or increased capillary pressure during increased blood flow. In the eye, several studies have reported that retinal blood flow is autoregulated over a wide range of ocular perfusion pressures. Unfortunately only few data are available for the optic nerve head. To gain data about autoregulation is of special importance given that several important ocular diseases such as glaucoma and age-related macular degeneration are associated with impaired autoregulation. In humans most data were collected using laser Doppler flowmetry. The present study aims to investigate the phenomenon of transient reduction in blood flow and to gain insight in the regulatory mechanisms of optic nerve head blood flow during isometric exercise.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
August 2012
Actual (reported)Click on a node to explore related trials.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
January 24, 2012
Actual (reported)February 2012
Date type not reportedThis date has not been verified as actual or estimated.
April 2012
Actual (reported)August 2012
Actual (reported)August 13, 2012
Actual (reported)Optic nerve head blood flow
12 minutes
Systolic/diastolic blood pressure
14 minutes
Intraocular pressure
at baseline and minute 13
Pulse rate
14 minutes
use of a handgrip for 3x2 minutes
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
Department of Clinical Pharmacology
Vienna, State of Vienna, 1090, Austria
Gerhard Garhöfer, MD
Department of Clinical Pharmacology, Medical University of Vienna
40 participants (actual enrollment reported by the registry).
First Submitted
January 24, 2012
First Posted
August 13, 2012
Study Start
February 2012
Date type not reportedThis date has not been verified as actual or estimated.
Effects of Increased Muscle Mass on Resting Metabolic Rate
Contact the study team to confirm eligibility.
Primary Completion
April 2012
Actual (reported)Study Completion
August 2012
Actual (reported)Last Updated
August 13, 2012
Record last verified: 2012-08
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Source: ClinicalTrials.gov.
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