Isometric Exercise and Endogenous Pain Inhibition

NCT03778476 | Completed

• 1 other identifier: HR3035
• Study Type: interventional
• Target: 43
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to identify the acute effects of isometric exercise on the inhibition of pain in individuals with fibromyalgia.

Conditions

Fibromyalgia

Keywords

Exercise; pain sensitivity; fibromyalgia

Outcome Measures

Primary Outcomes (1)

• Conditioned Pain Modulation

  the change in pressure pain threshold (kPa) during or after the immersion of the foot in a cold water bath (approximately 6 degrees) compared with baseline (before foot submersion) constitutes the measure of conditioned pain modulation in this study.

  baseline, immediately after exercise or quiet rest

Secondary Outcomes (1)

• Vibration Perception Threshold

  baseline, immediately after exercise or quiet rest

Other Outcomes (1)

• Numerical Pain Rating Scale (NPRS)

  baseline, during exercise, and immediately after exercise or quiet rest

Study Arms (2)

Isometric Exercise

EXPERIMENTAL

Participants will perform a submaximal voluntary contraction of the quadriceps muscle to task failure.

Other: Isometric Exercise

Quiet Rest

NO INTERVENTION

Participants will sit quietly for a period of time that mimics the exercise.

Interventions

Isometric Exercise OTHER

Participants will be asked to hold a submaximal voluntary contraction of the quadriceps muscle as long as they can (task failure).

Isometric Exercise

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Men and women aged 18-75 diagnosed with fibromyalgia or healthy controls will be included in the study.

You may not qualify if:

• cardiovascular disease, cancer, pregnancy, arthritis, diabetes, claustrophobia, Reynaud's disease, osteoporosis, neuropathy.

Sponsors & Collaborators

• Marquette University: lead

Study Sites (1)

Marquette University

Milwaukee, Wisconsin, 53233, United States

Location

MeSH Terms

Conditions

Fibromyalgia; Motor Activity

Interventions

Exercise

Condition Hierarchy (Ancestors)

Muscular Diseases; Musculoskeletal Diseases; Rheumatic Diseases; Neuromuscular Diseases; Nervous System Diseases; Behavior

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Marie Hoeger Bement, PT, PhD

  Marquette University

  PRINCIPAL INVESTIGATOR

• Ali Alsouhibani, PT, MS

  Marquette University

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Masking Details: The participant is masked to the hypotheses of the treatment.
• Purpose: TREATMENT
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: The two groups will participate in two sessions receiving intervention or no intervention in a randomized manner.

Study Record Dates

• First Submitted: December 12, 2018
• First Posted: December 19, 2018
• Study Start: May 25, 2018
• Primary Completion: September 29, 2019
• Study Completion: October 29, 2019
• Last Updated: February 24, 2021

Record last verified: 2021-02

Locations

US (1)