Rate Control in Atrial Fibrillation
Oral Propranolol, Diltiazem, Metoprolol and Verapamil in Atrial Fibrillation Rate Control in Patients With Stable Hemodynamic Status
1 other identifier
interventional
90
1 country
1
Brief Summary
Rate control in atrial fibrillation is a usual battle in emergency departments. Oral medications have a natural superiority to intravenous ones because they are easy-to-use and decrease the workload in busy emergency departments. This study wants to find an effective oral medication for rate control in rapid ventricular response atrial fibrillation. Propranolol and Metoprolol, Diltiazem and Verapamil are compared in patients with a stable hemodynamic status.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for phase_4
Started Feb 2011
Shorter than P25 for phase_4
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
February 1, 2011
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2011
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2011
CompletedFirst Submitted
Initial submission to the registry
July 30, 2012
CompletedFirst Posted
Study publicly available on registry
August 1, 2012
CompletedAugust 1, 2012
July 1, 2012
10 months
July 30, 2012
July 30, 2012
Conditions
Outcome Measures
Primary Outcomes (1)
Rate less than 100 per minute
Ventricular rate less than 100 per minute after 1 hour of per oral medication administration
In 1 hour
Secondary Outcomes (2)
Drugs adverse effects
2 hours
Unstability in hemodynamic
2 hours
Study Arms (4)
Metoprolol Per Oral
EXPERIMENTAL50 mg Metoprolol
Verapamil
EXPERIMENTAL40 mg Verapamil Per Oral
Propranolol
EXPERIMENTAL40 mg Propranolol Per Oral
Diltiazem
EXPERIMENTAL60 mg Diltiazem Per Oral
Interventions
Eligibility Criteria
You may qualify if:
- Age more than 18 years old
- Stability in hemodynamic
You may not qualify if:
- Systolic blood pressure less than 90 mm Hg
- Altered mental status attributable to rapid ventricular response atrial fibrillation
- Acute pulmonary edema attributable to rapid ventricular response atrial fibrillation
- Chest pain attributable to rapid ventricular response atrial fibrillation
- Allergy to Propranolol or Metoprolol or Verapamil or Diltiazem
- History of asthma
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Rasoul-e-Akram Hospital
Tehran, Tehran Province, 14436151, Iran
MeSH Terms
Interventions
Intervention Hierarchy (Ancestors)
Study Design
- Study Type
- interventional
- Phase
- phase 4
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- PARTICIPANT, CARE PROVIDER
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
July 30, 2012
First Posted
August 1, 2012
Study Start
February 1, 2011
Primary Completion
December 1, 2011
Study Completion
December 1, 2011
Last Updated
August 1, 2012
Record last verified: 2012-07