NCT01653535

Brief Summary

The primary aim of this project is to evaluate the effects of a comprehensive intervention to prevent severe and chronic conduct problems in a sample of children selected as high-risk when they first entered school. It is hypothesized that the intervention will have positive effects on proximal child behavior in middle school, and high school affecting long-term adolescent outcomes such as conduct disorder, juvenile delinquency, school dropout, substance use, teen pregnancy, relational competence with peers, romantic partners and parents, education and employment and social and community integration.

Trial Health

75
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
891

participants targeted

Target at P75+ for not_applicable

Timeline
40mo left

Started Mar 1991

Longer than P75 for not_applicable

Geographic Reach
1 country

1 active site

Status
active not recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress92%
Mar 1991Aug 2029

Study Start

First participant enrolled

March 1, 1991

Completed
21.4 years until next milestone

First Submitted

Initial submission to the registry

July 16, 2012

Completed
15 days until next milestone

First Posted

Study publicly available on registry

July 31, 2012

Completed
17 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

August 1, 2029

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

August 1, 2029

Last Updated

February 18, 2025

Status Verified

February 1, 2025

Enrollment Period

38.4 years

First QC Date

July 16, 2012

Last Update Submit

February 14, 2025

Conditions

Conduct DisorderAnti-Social Behavior

Keywords

PreventionHealth Service UseBehavioral InterventionConduct ProblemsAnti-Social Behavior

Outcome Measures

Primary Outcomes (1)

  • Anti-Social Behaviors

    Assessment of participant rates of anti-social behaviors (e.g., fighting, criminal activity)

    Grades 1-12 and Ages 19, 20, 25, 32, 34, 41

Secondary Outcomes (9)

  • Substance Usage

    Grades 6-12 and Ages 19, 20, 25, 32, 34, 41

  • Sexual Activity

    Grades 6-12 and Ages 19, 20, 25, and 32

  • Psychiatric Disorders

    Grades 6-12 and Ages 19, 20, 25, 32, and 34

  • Academic Achievement

    Grades 1-12 and Ages 19, 20, 25, 32, and 34

  • Financial Well-Being

    Grades 10-12 and Ages 19, 20, 25, 32, 34, 41

  • +4 more secondary outcomes

Study Arms (2)

Fast Track Eligible

EXPERIMENTAL

Participants in the Experimental group received the "Fast Track" intervention. Intervention included school-based curriculum attended by high-risk children, parents, program staff, and occasionally teachers, home visiting, the the in-class PATHS prevention program.

Behavioral: Fast Track

Control Group

NO INTERVENTION

Participants in the Control group were not eligible to receive the Fast Track intervention. These children received other services as usual, and served as the randomized comparison group for examining Fast Track program impacts

Interventions

Fast TrackBEHAVIORAL

First grade intervention included a weekly two-hour curriculum-based day that was attended by high-risk children, parents, program staff, and teachers of the high-risk children. During each session, the staff modeled academic tutoring with target children in the presence of their parents. In 3rd and 4th grades, intervention consisted of monthly parent and child curriculum-based sessions during the academic year, home visiting, and teachers implementing the in-class PATHS prevention program. In 5th and 6th grades, intervention included monthly parent and child groups and home visiting. In grades 8, 9 and 10 staff developed sessions on an as needed basis to cover topics like transition to high school, note-taking, and study skills.

Also known as: Conduct Problems Prevention Research Group
Fast Track Eligible

Eligibility Criteria

Age6 Years - 8 Years
Sexall
Healthy VolunteersYes
Age GroupsChild (0-17)

You may qualify if:

  • must be in public schools in 4 study sites
  • must be in 1st grade

You may not qualify if:

  • cannot be older than 1st grade
  • could not score in the top 40% on the TOCA-R

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Duke University

Durham, North Carolina, 27705, United States

Location

Related Publications (23)

  • Rothenberg WA, Lansford JE, Godwin JW, Dodge KA, Copeland WE, Odgers CL, McMahon RJ, Goulter N; Conduct Problems Prevention Research Group. Intergenerational effects of the Fast Track intervention on the home environment: A randomized control trial. J Child Psychol Psychiatry. 2023 May;64(5):820-830. doi: 10.1111/jcpp.13648. Epub 2022 Jun 15.

    PMID: 35705512RESULT

  • Rothenberg WA, Lansford JE, Godwin JW, Dodge KA, Copeland WE, Odgers CL, McMahon RJ, Rybinska A; Conduct Problems Prevention Research Group. Intergenerational Effects of the Fast Track Intervention on Next-Generation Child Outcomes: A Preregistered Randomized Clinical Trial. Am J Psychiatry. 2024 Mar 1;181(3):213-222. doi: 10.1176/appi.ajp.20220927. Epub 2024 Feb 7.

    PMID: 38321914RESULT

  • McCabe G, Godwin JW, Rothenberg WA, Goulter N, Lansford JE; Conduct Problems Prevention Research Group. Fast Track Intervention Effects and Mechanisms of Action Through Established Adulthood. Prev Sci. 2025 May;26(4):667-680. doi: 10.1007/s11121-024-01736-0. Epub 2024 Oct 11.

    PMID: 39392546RESULT

  • Lansford JE, Godwin J, Copeland WE, Dodge KA, Odgers CL, Rothenberg WA, Rybinska A; Conduct Problems Prevention Research Group. Fast Track intervention effects on family formation. J Fam Psychol. 2023 Feb;37(1):54-64. doi: 10.1037/fam0001039. Epub 2022 Nov 3.

    PMID: 36326668RESULT

  • Jones D, Godwin J, Dodge KA, Bierman KL, Coie JD, Greenberg MT, Lochman JE, McMahon RJ, Pinderhughes EE. Impact of the fast track prevention program on health services use by conduct-problem youth. Pediatrics. 2010 Jan;125(1):e130-6. doi: 10.1542/peds.2009-0322. Epub 2009 Dec 14.

    PMID: 20008428RESULT

  • Slough NM, McMahon RJ, Bierman KL, Coie JD, Dodge KA, Foster EM, Greenberg MT, Lochman JE, McMahon RJ, Pinderhughes EE. Preventing Serious Conduct Problems in School-Age Youths: The Fast Track Program. Cogn Behav Pract. 2008 Feb 1;15(1):3-17. doi: 10.1016/j.cbpra.2007.04.002.

    PMID: 19890487RESULT

  • Bierman KL, Coie JD, Dodge KA, Foster EM, Greenberg MT, Lochman JE, McMahon RJ, Pinderhughes EE; Conduct Problems Prevention Research Group. The effects of the fast track program on serious problem outcomes at the end of elementary school. J Clin Child Adolesc Psychol. 2004 Dec;33(4):650-61. doi: 10.1207/s15374424jccp3304_1.

    PMID: 15498733RESULT

  • Bierman KL, Coie JD, Dodge KA, Greenberg MT, Lochman JE, McMahon RJ, Pinderhughes EE; Conduct Problems Prevention Research Group. Using the Fast Track randomized prevention trial to test the early-starter model of the development of serious conduct problems. Dev Psychopathol. 2002 Fall;14(4):925-43. doi: 10.1017/s0954579402004133.

    PMID: 12549710RESULT

  • Kam CM, Greenberg MT, Bierman KL, Coie JD, Dodge KA, Foster ME, Lochman JE, McMahon RJ, Pinderhughes EE; Conduct Problems Prevention Research Group. Maternal depressive symptoms and child social preference during the early school years: mediation by maternal warmth and child emotion regulation. J Abnorm Child Psychol. 2011 Apr;39(3):365-77. doi: 10.1007/s10802-010-9468-0.

    PMID: 21080053RESULT

  • Conduct Problems Prevention Research Group. The effects of the fast track preventive intervention on the development of conduct disorder across childhood. Child Dev. 2011 Jan-Feb;82(1):331-45. doi: 10.1111/j.1467-8624.2010.01558.x.

    PMID: 21291445RESULT

  • Conduct Problems Prevention Research Group. Fast Track intervention effects on youth arrests and delinquency. J Exp Criminol. 2010 Jun;6(2):131-157. doi: 10.1007/s11292-010-9091-7.

    PMID: 20577576RESULT

  • Conduct Problems Prevention Research Group. The effects of a multiyear universal social-emotional learning program: The role of student and school characteristics. J Consult Clin Psychol. 2010 Apr;78(2):156-68. doi: 10.1037/a0018607.

    PMID: 20350027RESULT

  • Dodge KA, Godwin J; Conduct Problems Prevention Research Group. Social-information-processing patterns mediate the impact of preventive intervention on adolescent antisocial behavior. Psychol Sci. 2013 Apr;24(4):456-65. doi: 10.1177/0956797612457394. Epub 2013 Feb 13.

    PMID: 23406610RESULT

  • Bierman KL, Coie J, Dodge K, Greenberg M, Lochman J, McMohan R, Pinderhughes E; Conduct Problems Prevention Research Group. School outcomes of aggressive-disruptive children: prediction from kindergarten risk factors and impact of the fast track prevention program. Aggress Behav. 2013 Mar-Apr;39(2):114-30. doi: 10.1002/ab.21467. Epub 2013 Feb 5.

    PMID: 23386568RESULT

  • Sorensen LC, Dodge KA; Conduct Problems Prevention Research Group. How Does the Fast Track Intervention Prevent Adverse Outcomes in Young Adulthood? Child Dev. 2016 Mar-Apr;87(2):429-45. doi: 10.1111/cdev.12467. Epub 2015 Dec 16.

    PMID: 26670938RESULT

  • Dodge KA, Bierman KL, Coie JD, Greenberg MT, Lochman JE, McMahon RJ, Pinderhughes EE; Conduct Problems Prevention Research Group. Impact of early intervention on psychopathology, crime, and well-being at age 25. Am J Psychiatry. 2015 Jan;172(1):59-70. doi: 10.1176/appi.ajp.2014.13060786. Epub 2014 Oct 31.

    PMID: 25219348RESULT

  • Albert D, Belsky DW, Crowley DM, Latendresse SJ, Aliev F, Riley B, Sun C; Conduct Problems Prevention Research Group; Dick DM, Dodge KA. Can Genetics Predict Response to Complex Behavioral Interventions? Evidence from a Genetic Analysis of the Fast Track Randomized Control Trial. J Policy Anal Manage. 2015 Summer;34(3):497-518. doi: 10.1002/pam.21811.

    PMID: 26106668RESULT

  • Albert D, Belsky DW, Crowley DM, Bates JE, Pettit GS, Lansford JE, Dick D, Dodge KA. Developmental mediation of genetic variation in response to the Fast Track prevention program. Dev Psychopathol. 2015 Feb;27(1):81-95. doi: 10.1017/S095457941400131X.

    PMID: 25640832RESULT

  • Zheng Y, Albert D, McMahon RJ, Dodge K, Dick D; Conduct Problems Prevention Research Group. Glucocorticoid Receptor (NR3C1) Gene Polymorphism Moderate Intervention Effects on the Developmental Trajectory of African-American Adolescent Alcohol Abuse. Prev Sci. 2018 Jan;19(1):79-89. doi: 10.1007/s11121-016-0726-4.

    PMID: 27817096RESULT

  • Goulter N, McMahon RJ, Dodge KA; Conduct Problems Prevention Research Group. Does the Fast Track Intervention Prevent Later Psychosis Symptoms? Prev Sci. 2019 Nov;20(8):1255-1264. doi: 10.1007/s11121-019-01041-1.

    PMID: 31422489RESULT

  • Godwin JW; Conduct Problems Prevention Research Group. The Fast Track intervention's impact on behaviors of despair in adolescence and young adulthood. Proc Natl Acad Sci U S A. 2020 Dec 15;117(50):31748-31753. doi: 10.1073/pnas.2016234117. Epub 2020 Dec 1.

    PMID: 33262281RESULT

  • Musci RJ, Kush JM, Masyn KE, Esmaeili MA, Susukida R, Goulter N, McMahon R, Eddy JM, Ialongo NS, Tolan P, Godwin J; Conduct Problems Prevention Research Group6; Wilcox HC. Psychosis Symptom Trajectories Across Childhood and Adolescence in Three Longitudinal Studies: An Integrative Data Analysis with Mixture Modeling. Prev Sci. 2023 Nov;24(8):1636-1647. doi: 10.1007/s11121-023-01581-7. Epub 2023 Aug 24.

    PMID: 37615885RESULT

  • Gorla L, Rothenberg WA, Godwin J, Copeland WE; Conduct Problems Prevention Research Group. Pathways of intergenerational transmission of depression: The role of the Fast Track intervention. Dev Psychopathol. 2025 Sep 10:1-11. doi: 10.1017/S0954579425100588. Online ahead of print.

    PMID: 40926564DERIVED

Related Links

MeSH Terms

Conditions

Conduct DisorderAntisocial Personality Disorder

Condition Hierarchy (Ancestors)

Attention Deficit and Disruptive Behavior DisordersNeurodevelopmental DisordersMental DisordersPersonality Disorders

Study Officials

  • Kenneth A Dodge, PhD

    Duke University

    PRINCIPAL INVESTIGATOR

  • Karen L Bierman, PhD

    Penn State University

    PRINCIPAL INVESTIGATOR

  • Mark T Greenberg, PhD

    Penn State University

    PRINCIPAL INVESTIGATOR

  • John E Lochman, PhD

    University of Alabama at Birmingham

    PRINCIPAL INVESTIGATOR

  • Robert J McMahon, PhD

    Simon Fraser University

    PRINCIPAL INVESTIGATOR

  • Ellen E Pinderhughes, PhD

    Tufts University

    PRINCIPAL INVESTIGATOR

  • Daniel M Crowley, PhD

    Penn State University

    PRINCIPAL INVESTIGATOR

  • Jennifer Lansford, PhD

    Duke University

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
PARTICIPANT
Purpose
PREVENTION
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

July 16, 2012

First Posted

July 31, 2012

Study Start

March 1, 1991

Primary Completion (Estimated)

August 1, 2029

Study Completion (Estimated)

August 1, 2029

Last Updated

February 18, 2025

Record last verified: 2025-02

Data Sharing

IPD Sharing
Will share

The Fast Track Project is committed to a policy of allowing the research community access to data, under conditions that strictly protect the rights and privacy of Fast Track participants. The research design that has guided Fast Track data collection over the entire study period requires a restricted-use mechanism for sharing the data with the research community. As noted, the restricted-use data policy currently applies to data collected in grades K-12 and at ages 19, 20, 25, 32 and 34. The full terms of the Fast Track data sharing plan and access criteria exceed the 1000 character limit. Full information about the data-use policy and application forms can be found at http://fasttrackproject.org/request-use-data.php

Shared Documents
STUDY PROTOCOL, SAP, ICF
Time Frame
Time Frames will vary, depending on the individual research plan.
Access Criteria
Eligibility of Investigators and Receiving Institutions In order to be considered eligible to receive Fast Track data, an investigator must have a Ph.D. or other terminal degree, and hold a faculty appointment or other research position at the receiving institution. Graduate students who wish to use Fast Track data for dissertation research must apply through their faculty advisors. Eligible receiving institutions include not-for-profit research organizations, government agencies, and institutions of higher education. Receiving institutions must have established protocols for reviewing research using sensitive data, through an Institutional Review Board or equivalent body.
More information

Locations

US(1)