Longitudinal Measures of Leptin in Pregnant Women Who Developed Preeclampsia

NCT01649167 | Completed

• 1 other identifier: MACSSD042010
• Study Type: observational
• Target: 55
• Locations: 0 countries
• Sites: N/A

Brief Summary

Background: Obesity in pregnancy is increasing and is a risk factor for metabolic pathology such as preeclampsia. Leptin is an adipokine which has a direct relationship to obesity. Aim: to measure leptin in lean, obese and diabetic pregnant women at three months intervals throughout their pregnancies. Methods: Pregnant women were recruited in the 1st trimester of pregnancy, and three groups were formed: a) with pregestational Body Mass Index (BMI) less than 25 kg/m2, b) BMI higher than 25 kg/m2 and c) with Gestational Diabetes Mellitus (GDM). Serum levels of leptin were measured with radioimmunoassay (RIA) technique.

Conditions

High-Risk Pregnancy

Keywords

body mass index; gestational diabetes; leptin; obesity; pregnancy.

Study Arms (3)

Overweight/obesity

Pregnant women with overweight/obesity

gestational diabetes

Pregnant women with gestational diabetes

normal weight

Pregnant women with normal weight

Eligibility Criteria

• Age: 16 Years - 46 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Women who had received medical attention during pregnancy at the HMPMP in Toluca, Mexico.

You may qualify if:

• Women in the first trimester of pregnancy who sought medical attention at the HMPMP, between 16 and 46 years of age with a singleton gestation.

You may not qualify if:

• A previously known chronic metabolic disease (diabetes, pregestational dyslipidemia, hypertension, collagen vascular diseases, inflammatory bowel disease and chronic inflammatory conditions, or corticosteroid use).

Sponsors & Collaborators

• Materno-Perinatal Hospital of the State of Mexico: lead
• Universidad Autonoma del Estado de Mexico: collaborator

Biospecimen

Retention: SAMPLES WITHOUT DNA

Serum

MeSH Terms

Conditions

Diabetes, Gestational; Obesity

Condition Hierarchy (Ancestors)

Pregnancy Complications; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Diabetes Mellitus; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Endocrine System Diseases; Overweight; Overnutrition; Nutrition Disorders; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Verónica Jackeline García Solorio, MSc

  Autonomous University of the State of Mexico

  PRINCIPAL INVESTIGATOR

• Hugo Mendieta Zerón, PhD

  Autonomous University of the State of Mexico

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Researcher of the Medical Research Center (CICMED)

Study Record Dates

• First Submitted: July 17, 2012
• First Posted: July 25, 2012
• Study Start: February 1, 2009
• Study Completion: November 1, 2010
• Last Updated: July 25, 2012

Record last verified: 2012-07