NCT01645800

Brief Summary

The aim of this study is to assess the effectiveness in preventing exacerbation of 52 weeks lysozyme administration in patients with COPD.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
408

participants targeted

Target at P75+ for phase_4

Timeline
Completed

Started Aug 2012

Typical duration for phase_4

Geographic Reach
1 country

25 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

July 18, 2012

Completed
2 days until next milestone

First Posted

Study publicly available on registry

July 20, 2012

Completed
12 days until next milestone

Study Start

First participant enrolled

August 1, 2012

Completed
2.4 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

January 1, 2015

Completed
2 months until next milestone

Study Completion

Last participant's last visit for all outcomes

March 1, 2015

Completed
Last Updated

October 21, 2015

Status Verified

October 1, 2015

Enrollment Period

2.4 years

First QC Date

July 18, 2012

Last Update Submit

October 20, 2015

Conditions

Keywords

Lysozyme hydrochlorideCOPD

Outcome Measures

Primary Outcomes (1)

  • Acute exacerbation of COPD

    52 weeks

Secondary Outcomes (1)

  • Yearly reduction in FEV1 and QOL assessed by CAT

    52 weeks

Study Arms (2)

Lysozyme hydrochloride

EXPERIMENTAL
Drug: Lysozyme hydrochloride

Placebo

PLACEBO COMPARATOR
Drug: Placebo

Interventions

LYL 90mg capsule: Three times daily for 52 weeks.

Lysozyme hydrochloride

Matching Placebo capsule: Three times daily for 52 weeks.

Placebo

Eligibility Criteria

Age20 Years - 84 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may not qualify if:

  • Patients with egg allergy
  • Patients with domiciliary oxygen therapy
  • Patients with pneumonia or pulmonary tuberculosis
  • Patients with severe cardiovascular disorder,severe kidney disorder, severe hepatic disorder, severe hematological disorder.
  • Patients with cancer.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (25)

Unknown Facility

Nishio, Aichi-ken, Japan

Location

Unknown Facility

Noda, Chiba, Japan

Location

Unknown Facility

Fukuoka, Fukuoka, Japan

Location

Unknown Facility

Kasuga, Fukuoka, Japan

Location

Unknown Facility

Kyoto-gun, Fukuoka, Japan

Location

Unknown Facility

Yanagawa, Fukuoka, Japan

Location

Unknown Facility

Mabashi, Gunma, Japan

Location

Unknown Facility

Takasaki, Gunma, Japan

Location

Unknown Facility

Kitahiroshima, Hokkaido, Japan

Location

Unknown Facility

Sapporo, Hokkaido, Japan

Location

Unknown Facility

Himeji, Hyōgo, Japan

Location

Unknown Facility

Takamatsu, Kagawa-ken, Japan

Location

Unknown Facility

Yokohama, Kanagawa, Japan

Location

Unknown Facility

Yokosuka, Kanagawa, Japan

Location

Unknown Facility

Nagaoka, Niigata, Japan

Location

Unknown Facility

Ōita, Oita Prefecture, Japan

Location

Unknown Facility

Okayama, Okyama, Japan

Location

Unknown Facility

Osaka, Osaka, Japan

Location

Unknown Facility

Suita, Osaka, Japan

Location

Unknown Facility

Chuo-ku, Tokyo, Japan

Location

Unknown Facility

Edogawa-ku, Tokyo, Japan

Location

Unknown Facility

Higashikurume, Tokyo, Japan

Location

Unknown Facility

Koto-ku, Tokyo, Japan

Location

Unknown Facility

Setagaya-ku, Tokyo, Japan

Location

Unknown Facility

Yamagata, Yamagata, Japan

Location

MeSH Terms

Conditions

Pulmonary Disease, Chronic Obstructive

Condition Hierarchy (Ancestors)

Lung Diseases, ObstructiveLung DiseasesRespiratory Tract DiseasesChronic DiseaseDisease AttributesPathologic ProcessesPathological Conditions, Signs and Symptoms

Study Officials

  • Yukinori Sakata

    Drug Fostering and evolution Coodination Department, Corporate Regulattory Compliance, Safety and Quality Assurance Headquaters, Eisai Co., Ltd., Japan

    STUDY DIRECTOR

Study Design

Study Type
interventional
Phase
phase 4
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
PARTICIPANT, INVESTIGATOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

July 18, 2012

First Posted

July 20, 2012

Study Start

August 1, 2012

Primary Completion

January 1, 2015

Study Completion

March 1, 2015

Last Updated

October 21, 2015

Record last verified: 2015-10

Locations