Obesity as a Risk Factor for Musculoskeletal Diseases in the U.S. Air Force: Associations and Implications for Force Readiness

NCT01613001 | Completed

• 1 other identifier: FWH20120036H
• Study Type: observational
• Target: 67,904
• Locations: 0 countries
• Sites: N/A

Brief Summary

To study the first hypothesis, a retrospective cohort analysis of Air Force members from January 2005 to December 2010 will be performed to evaluate the association of obesity as an independent predictor variable with musculoskeletal disease as the dependent variable.

Conditions

Obesity

Outcome Measures

Primary Outcomes (1)

• Obesity vs musculoskeletal disease risk

  within 7 years

Study Arms (1)

DoD Beneficiaries

Exclusion: Active Duty Air Force members with the following conditions will be excluded from the study: * Documented preexisting musculoskeletal injury/disease before onset of obesity * Hypothyroidism/Hyperthyroidism * Hyperparathyroidism * Osteopenia/Osteoporosis * Nicotine dependence * Alcohol dependence * Eating disorders (anorexia nervosa, bulimia nervosa) * Cancer requiring chemotherapy or radiation therapy * Status-post gastrectomy * Status-post bilateral oophorectomy * Crohn's Disease * Ulcerative Colitis * Celiac Disease * Cushing's Disease * Prior to or during the study period, more than 6 months of taking proton pump inhibitors, medroxyprogesterone acetate, bisphosphonates, methotrexate, selective serotonin reuptake inhibitors, or inhaled/intranasal corticosteroids * Prior to or during the study period, more than 1 month of taking fluoroquinolones, oral or intramuscular corticosteroids, oral or intramuscular testosterone, or leuprolide

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

DoD Beneficiaries

You may not qualify if:

• Documented preexisting musculoskeletal injury/disease before onset of obesity
• Hypothyroidism/Hyperthyroidism
• Hyperparathyroidism
• Osteopenia/Osteoporosis
• Nicotine dependence
• Alcohol dependence
• Eating disorders (anorexia nervosa, bulimia nervosa)
• Cancer requiring chemotherapy or radiation therapy
• Status-post gastrectomy
• Status-post bilateral oophorectomy
• Crohn's Disease
• Ulcerative Colitis
• Celiac Disease
• Cushing's Disease
• Prior to or during the study period, more than 6 months of taking proton pump inhibitors, medroxyprogesterone acetate, bisphosphonates, methotrexate, selective serotonin reuptake inhibitors, or inhaled/intranasal corticosteroids

Sponsors & Collaborators

• Mike O'Callaghan Military Hospital: lead

MeSH Terms

Conditions

Obesity

Condition Hierarchy (Ancestors)

Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Nathaniel Nye, MD

  Mike O'Callaghan Military Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: FED
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Clinical Research Coordinator

Study Record Dates

• First Submitted: June 4, 2012
• First Posted: June 6, 2012
• Study Start: March 1, 2012
• Primary Completion: November 1, 2013
• Study Completion: November 1, 2013
• Last Updated: October 16, 2014

Record last verified: 2013-07