Meta-analyses of the Effect of Dietary Pulses on Acute Postprandial Metabolic Control

NCT01605422 | Unknown

• 1 other identifier: PC 2011 KRS
• Study Type: observational
• Target: 1
• Locations: 1 country
• Sites: 1

Brief Summary

Dietary pulses (beans, peas, chickpeas, and lentils), more commonly known as "legumes", are generally recognized as healthy components of the diet. Canada's Food Guide encourages consumptions of meat alternatives, such as beans "more often"; and the dietary guidelines for Americans both recommend consumption of 3 cups of legumes per week. However, there remains insufficient information on the usefulness of these foods in protecting heart health. To improve evidence-based guidance for dietary pulse recommendations, the investigators propose to conduct a systematic review of the effect of dietary pulse consumption on after-meal blood sugar levels, appetite, and food intake regulation to help explain their mechanism for improving longterm blood sugar and body weight control. The systematic review process allows the combining of the results from many small studies in order to arrive at a pooled estimate, similar to a weighted average, of the true effect. The investigators will be able to explore whether eating pulses has different effects between men and women, in different age groups and background disease states, and whether or not the effect of pulses depends on the dose and background diet. The findings of this proposed knowledge synthesis will help improve the health of Canadians through informing recommendations for the general public, as well as those at risk of heart disease and diabetes.

Conditions

Diabetes; Prediabetes; Dysglycemia; Overweight; Obesity; Metabolic Syndrome; Cardiovascular Disease

Keywords

Systematic review and meta-analysis; Evidence-based medicine (EBM); Evidence-based nutrition (EBN); Clinical practice guidelines; Clinical trials; Dietary pulses; legumes; Beans, peas, chickpeas, lentils; glycemic index; postprandial glycemia; insulin resistance; body weight; appetite; food intake regulation; satiety; satiation

Outcome Measures

Primary Outcomes (2)

• Effect of pulse consumption on post-prandial glycemia in acute, single bolus controlled feeding trials.

  Area under the curve \[AUC\], glycemic index (GI)

  Up to 1.5-years

• Effect of pulse consumption on satiety in acute, single bolus controlled feeding trials.

  Subjective appetite scores, 2nd meal intake

  Up to 1.5-years

Interventions

Dietary pulses OTHER

beans, peas, chickpeas, lentils in whole or flour form

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Varied

You may qualify if:

• dietary trials in humans
• acute, single bolus feeding
• control matched for available carbohydrate
• viable endpoint data

You may not qualify if:

• non-human studies
• chronic feeding
• lack of a suitable control (not matched for available carbohydrate)
• no viable endpoint data

Sponsors & Collaborators

• John Sievenpiper: lead
• Pulse Canada: collaborator
• Canada Research Chairs Endowment of the Federal Government of Canada: collaborator
• Canadian Institutes of Health Research (CIHR): collaborator

Study Sites (1)

The Toronto 3D (Diet, Digestive tract and Disease) Knowledge Synthesis and Clinical Trials Unit, Clinical Nutrition and Risk Factor Modification Centre, St. Micheal's Hospital

Toronto, Ontario, M5C 2T2, Canada

Location

Related Publications (2)

• Sievenpiper JL, Kendall CW, Esfahani A, Wong JM, Carleton AJ, Jiang HY, Bazinet RP, Vidgen E, Jenkins DJ. Effect of non-oil-seed pulses on glycaemic control: a systematic review and meta-analysis of randomised controlled experimental trials in people with and without diabetes. Diabetologia. 2009 Aug;52(8):1479-95. doi: 10.1007/s00125-009-1395-7. Epub 2009 Jun 13.

  PMID: 19526214 BACKGROUND

• Li SS, Kendall CW, de Souza RJ, Jayalath VH, Cozma AI, Ha V, Mirrahimi A, Chiavaroli L, Augustin LS, Blanco Mejia S, Leiter LA, Beyene J, Jenkins DJ, Sievenpiper JL. Dietary pulses, satiety and food intake: a systematic review and meta-analysis of acute feeding trials. Obesity (Silver Spring). 2014 Aug;22(8):1773-80. doi: 10.1002/oby.20782. Epub 2014 May 13.

  PMID: 24820437 RESULT

MeSH Terms

Conditions

Diabetes Mellitus; Prediabetic State; Overweight; Obesity; Metabolic Syndrome; Cardiovascular Diseases; Insulin Resistance; Body Weight

Condition Hierarchy (Ancestors)

Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Endocrine System Diseases; Overnutrition; Nutrition Disorders; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Hyperinsulinism

Study Officials

• John L Sievenpiper, MD, PhD

  Department of Pathology and Molecular Medicine, McMaster University and Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital

  STUDY DIRECTOR

• Russell J de Souza, ScD, RD

  Department of Epidemiology and Biostatistics, McMaster University and Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital

  STUDY DIRECTOR

• David JA Jenkins, MD, PhD, DSc

  Department of Nutritional Sciences and Medicine, University of Toronto and Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital

  PRINCIPAL INVESTIGATOR

• Cyril WC Kendall, PhD

  Department of Nutritional Sciences, University of Toronto and College of Pharamcy and Nutrition, University of Saskatchewan

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Adjunct Research Fellow

Study Record Dates

• First Submitted: May 18, 2012
• First Posted: May 24, 2012
• Study Start: October 1, 2011
• Primary Completion: September 1, 2013
• Study Completion: December 1, 2015
• Last Updated: May 27, 2015

Record last verified: 2015-05

Locations

CA (1)