NCT01604538

Brief Summary

RAZIONALE Pulmonary embolism is a complex disease, with a highly variable clincal presentation. Diagnosis starts with clinical probability assessment mainly based on medical history and rapidly available clinical data. Pulmonary embolism can be managed by emergency department, cardiology, pneumology geriatrics or internal medicine physicians. Thus, initial clinical management can varies based on the attitude of the attending physician. Diagnosis is a crucial point as it can influence short term mortality. OBJECTIVE The registry has 3 main objectives:

  1. 1.educational objective,
  2. 2.improvement in the knowledge of epidemiology, management and outcome of acute pulmonary embolism in Italy
  3. 3.scientific objective

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
1,700

participants targeted

Target at P75+ for all trials

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

March 1, 2006

Completed
6.2 years until next milestone

First Submitted

Initial submission to the registry

May 21, 2012

Completed
2 days until next milestone

First Posted

Study publicly available on registry

May 23, 2012

Completed
Last Updated

May 23, 2012

Status Verified

May 1, 2012

First QC Date

May 21, 2012

Last Update Submit

May 21, 2012

Conditions

Acute Pulmonary Embolism

Study Arms (1)

patients with acute pulmonary embolism

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

consecutive patients with acute pulmonary embolism

You may qualify if:

  • consecutive patients with acute pulmonary embolism

You may not qualify if:

  • age \<18 years

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Related Publications (8)

  • Zuin M, Bilato C, Enea I, Bongarzoni A, Casazza F, Roncon L, Becattini C. The STAMP score: An exploratory model for short-term risk stratification in intermediate-high-risk pulmonary embolism running head: The STAMP score. Eur J Intern Med. 2025 Aug 20:106484. doi: 10.1016/j.ejim.2025.106484. Online ahead of print.

    PMID: 40841246DERIVED

  • Zuin M, Piazza G, Rigatelli G, Bongarzoni A, Enea I, Casazza F, Picariello C, Bilato C, Roncon L. Clinical phenotypes and risk of early hemodynamic deterioration in intermediate-high-risk patients with acute pulmonary embolism. Thromb Res. 2025 Aug;252:109380. doi: 10.1016/j.thromres.2025.109380. Epub 2025 Jun 10.

    PMID: 40505225DERIVED

  • Zuin M, Rigatelli G, Bilato C, Bongarzoni A, Zonzin P, Casazza F, Roncon L. Risk of early clinical deterioration and 30-day mortality in pulmonary embolism intermediate-high-risk patients with patent foramen ovale. Intern Emerg Med. 2024 Sep;19(6):1637-1644. doi: 10.1007/s11739-024-03657-w. Epub 2024 May 31.

    PMID: 38822190DERIVED

  • Zuin M, Piazza G, Rigatelli G, Bilato C, Bongarzoni A, Henkin S, Zonzin P, Casazza F, Roncon L. Prognostic Role of Tricuspid Annular Plane Systolic Excursion to Systolic Pulmonary Artery Pressure Ratio for the Identification of Early Clinical Deterioration in Intermediate-High-Risk Pulmonary Embolism Patients. Am J Cardiol. 2024 Mar 1;214:40-46. doi: 10.1016/j.amjcard.2023.12.053. Epub 2024 Jan 11.

    PMID: 38218392DERIVED

  • Zuin M, Bilato C, Bongarzoni A, Zonzin P, Casazza F, Roncon L. Prognostic impact of the e-TAPSE ratio in intermediate-high risk pulmonary embolism patients. Int J Cardiovasc Imaging. 2024 Mar;40(3):467-476. doi: 10.1007/s10554-023-03010-w. Epub 2023 Nov 30.

    PMID: 38032504DERIVED

  • Zuin M, Rigatelli G, Bongarzoni A, Enea I, Bilato C, Zonzin P, Casazza F, Roncon L. Mean arterial pressure predicts 48 h clinical deterioration in intermediate-high risk patients with acute pulmonary embolism. Eur Heart J Acute Cardiovasc Care. 2023 Feb 9;12(2):80-86. doi: 10.1093/ehjacc/zuac169.

    PMID: 36580441DERIVED

  • Zuin M, Bilato C, Bongarzoni A, Zonzin P, Casazza F, Rigatelli G, Roncon L. Impact of clinical profile at admission on the outcomes in patients hospitalized for acute pulmonary embolism: data from the IPER Registry. J Thromb Thrombolysis. 2023 Jan;55(1):166-174. doi: 10.1007/s11239-022-02726-1. Epub 2022 Nov 9.

    PMID: 36350468DERIVED

  • Becattini C, Casazza F, Forgione C, Porro F, Fadin BM, Stucchi A, Lignani A, Conte L, Imperadore F, Bongarzoni A, Agnelli G. Acute pulmonary embolism: external validation of an integrated risk stratification model. Chest. 2013 Nov;144(5):1539-1545. doi: 10.1378/chest.12-2938.

    PMID: 23764909DERIVED

Study Officials

  • Franco Casazza, MD

    San Carlo Borromeo hospital, Milan, Italy

    STUDY CHAIR

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Dr

Study Record Dates

First Submitted

May 21, 2012

First Posted

May 23, 2012

Study Start

March 1, 2006

Last Updated

May 23, 2012

Record last verified: 2012-05