Establish a Vegetable Signature Database From Human Metabolomics Responses

NCT01600911 | Unknown

• 1 other identifier: EC0991003
• Study Type: interventional
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

Vegetable is well known to prevent chronic disease,however, the mechanism of its nutrients and non-nutrients still remains to be discovered.We design a feeding study which provides plant foods to subjects one by another and monitoring metabolomic changes up to 7 hours.The goal of this study is to establish a protocol for documenting metabolomics response to plant foods and try to characterize plant foods in terms of their anti-hypertension potentials with metabolomic profiling information.

Conditions

Human Metabolomic Responses to Plant Foods; Blood Pressure

Keywords

metabolomics; nutri-metabolomics; plant food; blood pressure

Outcome Measures

Primary Outcomes (1)

• blood pressure

  fasting, before lunch,and every 1 hr after lunch

  one day

Secondary Outcomes (1)

• metabolomic profile of serum and urine

  one day

Interventions

Low phytochemical diet(LPD), high phytochemical diet(HPD) OTHER

LPD is a basal diet which low in soy,vegetable and fruit and other plant food to approach low phytochemical. HPD is the diet which add two serving test vegetable in the lunch of LPD.

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Age :18-60 years
• Body Mass Index :18.5-30(kg/m2)
• Non-smoking,alcohol abusing,and other bad hobbies

You may not qualify if:

• With regular drug intake e.g. anti-hypertensive or antidiabetes drug or history of immune, hepatic and metabolic disease or other unsuitable disorders e.g. cancer.
• unwilling to stop regular food supplement e.g. vitamins, herb
• cannot cooperate with designed diet
• History of urinary tract infection or antibiotic use within the previous 3 month

Sponsors & Collaborators

• National Health Research Institutes, Taiwan: lead
• Tri-Service General Hospital: collaborator

Study Sites (1)

National Health Research institues, Taiwan

Miaoli County, Taiwan

Location

Study Officials

• Wen-Harn Pan, Ph.D.

  National Health Research Institutes, Taiwan

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 16, 2012
• First Posted: May 17, 2012
• Study Start: December 1, 2010
• Primary Completion: December 1, 2013
• Study Completion: December 1, 2013
• Last Updated: May 18, 2012

Record last verified: 2012-05

Locations

TW (1)