Influence of Transcranial Direct Current Stimulation on Cortical Plasticity in Concussed Athletes
Influence of Anodal Transcranial Direct Current Stimulation on Cortical Plasticity in Concussed Athletes and Healthy Volunteers
1 other identifier
interventional
30
1 country
1
Brief Summary
Concussed athlethes have discrete decreased abilities in motor learning. Recent research could further show, that cortical plasticity, as measured by transcranial magnetic stimulation (TMS) is reduced. This is possibly due to an increased GABAergic activity, what have been found in concussed athletes by paired pulse protocols in TMS. GABAergic acitivty can be modulated by transcranial direct current stimulation (tDCS) in a polar-specific manner: anodal tDCS was able to decrease GABA, whereas cathodal tDCS increased tDCS. Our study aimes to assess the influence of anodal tDCS on cortical plsticity in concussed athlethes. We hypothesize, that anodal tDCS is able to increase cortical plsticity in concussed athlethes.
Trial Health
Trial Health Score
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participants targeted
Target at below P25 for not_applicable
1 active site
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Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
March 1, 2012
CompletedFirst Submitted
Initial submission to the registry
May 7, 2012
CompletedFirst Posted
Study publicly available on registry
May 8, 2012
CompletedPrimary Completion
Last participant's last visit for primary outcome
July 1, 2013
CompletedMay 23, 2013
May 1, 2013
1.3 years
May 7, 2012
May 22, 2013
Conditions
Outcome Measures
Primary Outcomes (1)
Improvement of cortical plasticity after anodal tDCS in concussed athletes
Study Arms (2)
Concussed athletes
OTHERHealthy controls
OTHERInterventions
Eligibility Criteria
You may qualify if:
- history of at least 2 sports concussion
- age 18 - 50 years
You may not qualify if:
- structural deficit on cerebral MRI
- Epilepsy
- neurological disorder
- intake of CNS-active drugs
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Charité - Department of neurology
Berlin, 10117, Germany
Related Publications (3)
De Beaumont L, Tremblay S, Poirier J, Lassonde M, Theoret H. Altered bidirectional plasticity and reduced implicit motor learning in concussed athletes. Cereb Cortex. 2012 Jan;22(1):112-21. doi: 10.1093/cercor/bhr096. Epub 2011 May 13.
PMID: 21572090BACKGROUNDStagg CJ, Bachtiar V, Johansen-Berg H. The role of GABA in human motor learning. Curr Biol. 2011 Mar 22;21(6):480-4. doi: 10.1016/j.cub.2011.01.069. Epub 2011 Mar 3.
PMID: 21376596BACKGROUNDStagg CJ, Best JG, Stephenson MC, O'Shea J, Wylezinska M, Kincses ZT, Morris PG, Matthews PM, Johansen-Berg H. Polarity-sensitive modulation of cortical neurotransmitters by transcranial stimulation. J Neurosci. 2009 Apr 22;29(16):5202-6. doi: 10.1523/JNEUROSCI.4432-08.2009.
PMID: 19386916BACKGROUND
MeSH Terms
Interventions
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Jonathan List, MD
Charité - Department of Neurology
- PRINCIPAL INVESTIGATOR
Agnes Flöel, Prof.
Charité - Department of Neurology
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Purpose
- TREATMENT
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- MD
Study Record Dates
First Submitted
May 7, 2012
First Posted
May 8, 2012
Study Start
March 1, 2012
Primary Completion
July 1, 2013
Last Updated
May 23, 2013
Record last verified: 2013-05