The Relation Between Uric Acid Level and Endothelial Dysfunction in Patients With Polycystic Kidney Disease

NCT01589705 | Terminated

• 1 other identifier: Erciyes 2011/273
• Study Type: observational
• Target: 150
• Locations: 1 country
• Sites: 1

Brief Summary

There are substantial data demonstrating increased endothelial dysfunction, inflammation and oxidative stress in patients with Autosomal dominant polycystic kidney disease (ADPKD), the association between serum uric acid level and endothelial dysfunction has not been elucidated yet in these patients. Therefore, in this study, the investigators aimed to examine the relationship between the uric acid level and the ED in normotensive ADPKD patients with preserved renal function.

Conditions

Polycystic Kidney, Autosomal Dominant

Keywords

Uric acid; polycystic kidney disease

Outcome Measures

Primary Outcomes (1)

• Measurement of asymmetric dimethylarginine (ADMA) and flow mediated dilatation (FMD)

  ADMA,FMD and uric acid measurements were performed to determine endothelial dysfunction in ADPKD patients

  4 months

Study Arms (1)

polycystic kidney ,no hypertension

The study evaluated the association of serum uric acid levels with endothelial dysfunction in early ADPKD patients with normal renal function

Eligibility Criteria

• Age: 20 Years - 60 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Patients with early stage(preserved renal function) Autosomal dominant polycystic kidney disease (n = 91) from two academic medical center.We also excluded the patients with a previous diagnosis of hypertension, gout, diabetes, current use of oral antidiabetic medication, insulin, thiazide, allopurinol or uricosuric, or a fasting glucose level 126 mg/dl. In addition, the subjects with a history of smoking or current use of any anti-hypertensive medication and statins were excluded

You may qualify if:

• ADPKD patients with normal renal function,
• Normotensive ADPKD patients

You may not qualify if:

• Patients with impaired kidney function,
• Atherosclerotic disorders,
• Diagnosis of hypertension, gout, diabetes,
• Using of insulin, thiazide, allopurinol or uricosuric drugs

Sponsors & Collaborators

• TC Erciyes University: lead

Study Sites (1)

Erciyes University Medical School

Kayseri, 38039, Turkey (Türkiye)

Location

Related Publications (1)

• Kocyigit I, Yilmaz MI, Orscelik O, Sipahioglu MH, Unal A, Eroglu E, Kalay N, Tokgoz B, Axelsson J, Oymak O. Serum uric acid levels and endothelial dysfunction in patients with autosomal dominant polycystic kidney disease. Nephron Clin Pract. 2013;123(3-4):157-64. doi: 10.1159/000353730. Epub 2013 Jul 25.

  PMID: 23887359 DERIVED

MeSH Terms

Conditions

Polycystic Kidney, Autosomal Dominant; Polycystic Kidney Diseases

Condition Hierarchy (Ancestors)

Kidney Diseases, Cystic; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Abnormalities, Multiple; Congenital Abnormalities; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Ciliopathies; Genetic Diseases, Inborn

Study Officials

• Bulent Tokgoz, Professor

  Erciyes University Medical School

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: TC Erciyes University Medical School

Study Record Dates

• First Submitted: April 30, 2012
• First Posted: May 2, 2012
• Study Start: January 1, 2012
• Primary Completion: April 1, 2012
• Study Completion: April 1, 2012
• Last Updated: July 31, 2012

Record last verified: 2012-07

Locations

TU (1)