Proton Pump Inhibitor Use is Associated With High Risk of Pneumonia in Chronic Kidney Disease Patients

NCT01588886 | Completed DMC

• 1 other identifier: 101013-E
• Study Type: observational
• Target: 9,000
• Locations: 0 countries
• Sites: N/A

Brief Summary

Chronic kidney disease is a severe medical problem in Taiwan public health issue, which the highest incidence and prevalence rate in the world.Proton pump inhibitors may increase the risk of pneumonia appearance, which were caused by profound irreversible gastric acid suppression. The study purpose was to characterize difference of developing pneumonia in chronic kidney disease of prior use proton pump inhibitors.

Conditions

Chronic Kidney Disease; Pneumonia

Keywords

Proton pump inhibitors; Pneumonia; Retrospective cohort study

Outcome Measures

Primary Outcomes (1)

• Chronic kidney disease ICD-9

  2012-Dec

Study Arms (2)

with PPI

CKD with PPI use, follow up at least 5 years began PPI use

with or without Pneumonia outcome

Patients were eligible for inclusion if they received any PPIs treatment between January 1, 1998 and December 31, 2002 and had been diagnosed with pneumonia between January 1, 1998 and December 31, 2008 in an inpatient setting.

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Investiators use the longitudinal health insurance database 2008 (LHID 2008) released by the Taiwan National Health Research Institutes (NHRI) in 2009. Taiwan implemented its National Health Insurance (NHI) program in 1995 to provide affordable health care for all the island's residents.

You may qualify if:

• Chronic kidney disease

You may not qualify if:

• excluded those patients who had ever been diagnosed with CKD before 1997

Sponsors & Collaborators

• Far Eastern Memorial Hospital: lead

Related Publications (3)

• Sheen E, Triadafilopoulos G. Adverse effects of long-term proton pump inhibitor therapy. Dig Dis Sci. 2011 Apr;56(4):931-50. doi: 10.1007/s10620-010-1560-3. Epub 2011 Mar 2.

  PMID: 21365243 RESULT

• Wu H, Jing Q, Wang J, Guo X. Pantoprazole for the prevention of gastrointestinal bleeding in high-risk patients with acute coronary syndromes. J Crit Care. 2011 Aug;26(4):434.e1-6. doi: 10.1016/j.jcrc.2010.12.007. Epub 2011 Jan 26.

  PMID: 21273036 RESULT

• Madanick RD. Proton pump inhibitor side effects and drug interactions: much ado about nothing? Cleve Clin J Med. 2011 Jan;78(1):39-49. doi: 10.3949/ccjm.77a.10087.

  PMID: 21199906 RESULT

MeSH Terms

Conditions

Renal Insufficiency, Chronic; Pneumonia

Condition Hierarchy (Ancestors)

Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Respiratory Tract Infections; Infections; Lung Diseases; Respiratory Tract Diseases

Study Officials

• Chen Chih-Hung, MD

  west-garden Hospital

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 27, 2012
• First Posted: May 1, 2012
• Study Start: March 1, 2012
• Primary Completion: June 1, 2012
• Study Completion: August 1, 2015
• Last Updated: February 16, 2017

Record last verified: 2013-11