ATACT
Prospective Study for the Follow-up of Aortic Diameter in Patients With Arteritis Temporalis / Giant Cell Arteritis.
Sponsor study identifier
observational
163
1 country
1
Study Start
March 1, 2012
Actual (reported)Primary Completion
April 1, 2023
Actual (reported)Study Completion
April 1, 2023
Actual (reported)Giant cell arteritis (GCA) is the most frequent vasculitis in patients above 50 years of age. The disease has limited mortality, mostly due to the development of aortic aneurysms, leading to dissection and rupture. The probability to develop this complication is 17 x higher at the level of the thoracic aorta and 2,4 x at the level of the abdominal aorta in patients with GCA when compared with a control group. Therefore, follow-up of the aortic diameter in patients with GCA is part of good clinical practice. Previous retrospective research showed a link between FDG-uptake at the level of the thoracic aorta, on positron-emission-tomography (PET) at the time of diagnosis, and the increase of diameter and volume of the thoracic aorta during follow-up (on computed tomography (CT)). The purpose of this prospective study is to follow-up on the aortic diameter, and to correlate these measures with FDG-PET uptake at diagnosis. Ideally, this would allow us to define a group of patients at high risk to develop an aortic aneurysm, already at the time of diagnosis.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
April 1, 2023
Actual (reported)Click on a node to explore related trials.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
March 1, 2012
Actual (reported)April 23, 2012
Actual (reported)May 1, 2012
Actual (reported)April 1, 2023
Actual (reported)April 1, 2023
Actual (reported)Diameter of aorta.
diameter of ascending aorta, arcus aortae, descending aorta, suprarenal, juxtarenal and infrarenal abdominal aorta
yearly, until 10 years after diagnosis
Volume of aorta
volume of the thoracic and abdominal aorta
yearly, until 10 years after diagnosis
patients with biopsy and/or scintigraphy proven GCA
Proven Giant Cell Arteritis
University Hospital Leuven
Leuven, 3000, Belgium
Blockmans D, Coudyzer W, Vanderschueren S, Stroobants S, Loeckx D, Heye S, De Ceuninck L, Marchal G, Bobbaers H. Relationship between fluorodeoxyglucose uptake in the large vessels and late aortic diameter in giant cell arteritis. Rheumatology (Oxford). 2008 Aug;47(8):1179-84. doi: 10.1093/rheumatology/ken119. Epub 2008 May 31.
Daniël Blockmans, MD, PhD
University Hospital, Gasthuisberg
163 participants (actual enrollment reported by the registry).
First Submitted
April 23, 2012
First Posted
May 1, 2012
Study Start
March 1, 2012
Actual (reported)Diagnostic Accuracy of FDG PET/CT of Cranial Arteries in GCA
Contact the study team to confirm eligibility.
Primary Completion
April 1, 2023
Actual (reported)Study Completion
April 1, 2023
Actual (reported)Last Updated
April 6, 2023
Record last verified: 2023-04
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Source: ClinicalTrials.gov.
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