Topographic Changes of Retinal Layers After Resolution of Acute Retinal Detachment

NCT01587794 | Completed

• 1 other identifier: 2011-3-31
• Study Type: observational
• Target: 21
• Locations: 0 countries
• Sites: N/A

Brief Summary

Experimental retinal detachment and reattachment models have demonstrated the recovery process of successfully reattached retina. However, optical coherence tomography analysis of each retinal layers following retinal reattachment has not been investigated This study investigated changes in thickness profiles of retinal layers after resolution of recent-onset rhegmatogenous retinal detachment (RRD) using optical coherence tomography images.

Conditions

Rhegmatogenous Retinal Detachment

Keywords

Rhegmatogenous retinal detachment; thickness of retinal layer; outer nuclear layer; photoreceptor layer

Outcome Measures

Primary Outcomes (1)

• Thickness of each retinal layer

  SD-OCT scans were performed for all patients enrolled using Spectralis optical coherence tomography. The thickness of each retinal layer was measured manually using the included Heidelberg Eye Explorer software.

  At least 6 months after the operation

Study Arms (1)

retinal detachment group

Patients who were diagnosed with unilateral rhegmatogenous retinal detachment involving only the superior or inferior half of the retina and who underwent successful scleral buckling procedure or vitrectomy by a single surgeon between January 1, 2008 and April 1, 2010 were included in the study sample.

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients who were diagnosed with unilateral RRD involving only the superior or inferior half of the retina and who underwent successful scleral buckling procedure or vitrectomy by a single surgeon between January 1, 2008 and April 1, 2010 were included in the study sample.

You may qualify if:

• Patients who could estimate the time of onset of visual symptom of retinal detachment (sudden decrease in visual acuity or onset of visual field defect) accurately

You may not qualify if:

• traumatic retinal detachment
• recurred retinal detachment
• less than 6 months of follow-up after surgery
• insufficient cooperation for optical coherence tomography examination
• media opacity that would preclude acquisition of clear optical coherence tomography images
• diopters or more of spherical equivalent
• prominent staphyloma
• history of intraocular surgery other than cataract surgery or intraocular lens implantation
• other ocular diseases that may influence the macular microstructure.
• individuals with indistinct intraretinal structure on optical coherence tomography images
• large retinal vessels at the location of thickness measurement, or epiretinal membrane

Sponsors & Collaborators

• Samsung Medical Center: lead

Related Publications (1)

• Kim JH, Park DY, Ha HS, Kang SW. Topographic changes of retinal layers after resolution of acute retinal detachment. Invest Ophthalmol Vis Sci. 2012 Oct 23;53(11):7316-21. doi: 10.1167/iovs.12-10155.

  PMID: 23033395 DERIVED

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: M.D.

Study Record Dates

• First Submitted: March 31, 2012
• First Posted: April 30, 2012
• Study Start: April 1, 2010
• Primary Completion: April 1, 2011
• Study Completion: April 1, 2011
• Last Updated: April 30, 2012

Record last verified: 2012-04