Chest CT-scan for the Diagnosis of Community-acquired Pneumonia
PACSCAN
2 other identifiers
interventional
339
1 country
4
Brief Summary
Primary objective : to estimate impact of CT-scan on diagnostic for emergency department (ED) patients with suspected Community-acquired Pneumonia (CAP). Secondary objective: to estimate impact of CT-scan on treatment (antimicrobial therapy) and site of care for ED patients with suspected CAP.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable
Started Nov 2011
4 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
November 1, 2011
CompletedFirst Submitted
Initial submission to the registry
February 7, 2012
CompletedFirst Posted
Study publicly available on registry
April 10, 2012
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2012
CompletedStudy Completion
Last participant's last visit for all outcomes
July 1, 2013
CompletedDecember 1, 2025
November 1, 2025
1.1 years
February 7, 2012
November 24, 2025
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Chest CT-scan
Percentage of diagnoses modified by chest CT-scan.
in 28 days
Secondary Outcomes (5)
Treatments changes
in 28 days
Changes of site-of-care
in 28 days
Identification of viral and bacterial agents
at day of inclusion (day 1)
Markers of infection in the blood
at day of inclusion (day 1)
Markers of infection and markers of inflammation in urine
at day of inclusion (day 1)
Study Arms (1)
Chest CT-scan
EXPERIMENTALPatients with a suspicion of acquired pneumonia visiting the emergency department will do a chest CT-scan
Interventions
Patients with a suspicion of acquired pneumonia visiting the emergency department will do a chest CT-scan
Eligibility Criteria
You may qualify if:
- Patient above 18 years of age
- Patient with a presumptive diagnosis of CAP according to attending ED physician
- Patient experiencing at least one systemic sign (T°\>38°C or \< 36°C, HR\>90/min, RR\>20/min)
- Patient experiencing one respiratory sign (cough, lateral chest pain, localized crackles, dyspnea) that recently appeared
- Patient with a prior medical examination, the results have been or will be communicated
You may not qualify if:
- Pregnancy
- Patient with shock
- Patient with respiratory distress and immune suppression
- Patient with other criteria for immediate ICU referral to ICU
- Patient with living conditions making it impossible to follow 28 days
- Patient not affiliated with a social security system
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (4)
La Pitié Salpêtrière Hospital
Paris, 75013, France
Cochin Hospital
Paris, 75014, France
Bichat Hospital
Paris, 75018, France
Tenon Hospital
Paris, 75020, France
Related Publications (6)
Claessens YE, Debray MP, Tubach F, Brun AL, Rammaert B, Hausfater P, Naccache JM, Ray P, Choquet C, Carette MF, Mayaud C, Leport C, Duval X. Early Chest Computed Tomography Scan to Assist Diagnosis and Guide Treatment Decision for Suspected Community-acquired Pneumonia. Am J Respir Crit Care Med. 2015 Oct 15;192(8):974-82. doi: 10.1164/rccm.201501-0017OC.
PMID: 26168322RESULTLe Bel J, Hausfater P, Chenevier-Gobeaux C, Blanc FX, Benjoar M, Ficko C, Ray P, Choquet C, Duval X, Claessens YE; ESCAPED study group. Diagnostic accuracy of C-reactive protein and procalcitonin in suspected community-acquired pneumonia adults visiting emergency department and having a systematic thoracic CT scan. Crit Care. 2015 Oct 16;19:366. doi: 10.1186/s13054-015-1083-6.
PMID: 26472401RESULTDas D, Le Floch H, Houhou N, Epelboin L, Hausfater P, Khalil A, Ray P, Duval X, Claessens YE, Leport C; ESCAPED Study Group. Viruses detected by systematic multiplex polymerase chain reaction in adults with suspected community-acquired pneumonia attending emergency departments in France. Clin Microbiol Infect. 2015 Jun;21(6):608.e1-8. doi: 10.1016/j.cmi.2015.02.014. Epub 2015 Feb 20.
PMID: 25704448RESULTHofmeister J, Garin N, Montet X, Scheffler M, Platon A, Poletti PA, Stirnemann J, Debray MP, Claessens YE, Duval X, Prendki V. Validating the accuracy of deep learning for the diagnosis of pneumonia on chest x-ray against a robust multimodal reference diagnosis: a post hoc analysis of two prospective studies. Eur Radiol Exp. 2024 Feb 2;8(1):20. doi: 10.1186/s41747-023-00416-y.
PMID: 38302850DERIVEDTubiana S, Epelboin L, Casalino E, Naccache JM, Feydy A, Khalil A, Hausfater P, Duval X, Claessens YE; ESCAPED study group. Effect of diagnosis level of certainty on adherence to antibiotics' guidelines in ED patients with pneumonia: a post-hoc analysis of an interventional trial. Eur J Emerg Med. 2023 Apr 1;30(2):102-109. doi: 10.1097/MEJ.0000000000000954. Epub 2022 Jun 27.
PMID: 35758267DERIVEDLe Bel J, Pelaccia T, Ray P, Mayaud C, Brun AL, Hausfater P, Casalino E, Benjoar M, Claessens YE, Duval X; ESCAPED study group. Impact of emergency physician experience on decision-making in patients with suspected community-acquired pneumonia and undergoing systematic thoracic CT scan. Emerg Med J. 2019 Aug;36(8):485-492. doi: 10.1136/emermed-2018-207842. Epub 2019 Jun 24.
PMID: 31239315DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Yann-Erick Claessens, MD, PhD
Cochin Hospital, Paris, France
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NA
- Masking
- NONE
- Purpose
- DIAGNOSTIC
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
February 7, 2012
First Posted
April 10, 2012
Study Start
November 1, 2011
Primary Completion
December 1, 2012
Study Completion
July 1, 2013
Last Updated
December 1, 2025
Record last verified: 2025-11