Dual Task Aerobic Exercise for Older Adults With Cognitive Impairment (HM2)

NCT01572311 | Completed

• 1 other identifier: DAE-1234
• Study Type: interventional
• Target: 44
• Locations: 1 country
• Sites: 1

Brief Summary

The investigators proposed research will establish whether combining aerobic exercise with cognitive challenges is feasible and effective in community dwelling older adults with early signs of cognitive impairment.

Conditions

Cognitive Impairment

Keywords

Aerobic exercise; Cognition; Dual Task; Gait Training; Group-based exercise; Older adults

Outcome Measures

Primary Outcomes (1)

• Global cognitive functioning

  Four standardized domain-specific composite scores were averaged to create this standardized global cognitive functioning score (incorporates executive function, processing speed, verbal learning and memory, and verbal fluency.

  26 weeks

Secondary Outcomes (21)

• Global cognitive functioning

  12 & 52 weeks

• Executive Function/Mental Flexibility

  12, 26, and 52 weeks

• Processing Speed

  12, 26 and 52 weeks

• Verbal Learning and Memory

  12, 26 and 52 weeks

• Verbal Fluency

  12, 26 and 52 weeks

Study Arms (2)

Exercise Intervention Group

EXPERIMENTAL

For 26 weeks, attend Canadian Centre for Activity and Aging combined classes (75-minute or 60-minute classes, 2 to 3 days/week) and also complete 45 minutes of dual-task gait training (15 minutes for 3 days/week or 22.5 minutes for 2 days/week)

Behavioral: Exercise Intervention

Exercise Control group

ACTIVE COMPARATOR

For 26 weeks, attend Canadian Centre for Activity and Aging combined classes (75-minute or 60-minute classes, 2 to 3 days/week) and also complete 45 minutes of gait training (15 minutes for 3 days/week or 22.5 minutes for 2 days/week). Note: no dual-task challenges during gait training

Behavioral: Exercise Control

Interventions

Exercise Intervention BEHAVIORAL

Goal of 150 minutes of structured exercise/week; minimum of 120 minutes from CCAA classes/week. The 75-minute class includes: 5-minute warm-up; 25 minutes of AE (70-85% maximum heart rate); 5-minute cool-down; 20 minutes of strength training; 5 minutes of core strengthening; 5 minutes of balance training; and 10 minutes of stretching. The 60-minute program is identical except: 15 minutes total for all strength training (including core) and 5 minutes of stretching. Following CCAA classes, participants continue with dual-task gait training where they are required to walk on a special mat with a designated walking pattern (beginner level Square Stepping Exercise) while answering cognitively challenging questions.

Also known as: Aerobic exercise and dual-task training

Exercise Intervention Group

Exercise Control BEHAVIORAL

Goal of 150 minutes of structured exercise/week; minimum of 120 minutes from CCAA classes/week. The 75-minute class includes: 5-minute warm-up; 25 minutes of AE (70-85% maximum heart rate); 5-minute cool-down; 20 minutes of strength training; 5 minutes of core strengthening; 5 minutes of balance training; and 10 minutes of stretching. The 60-minute program is identical except: 15 minutes total for all strength training (including core) and 5 minutes of stretching. Following CCAA classes, participants continue with gait training where they are required to walk on a special mat with a designated walking pattern (beginner level Square Stepping Exercise). This will not include any dual-task challenges.

Also known as: Aerobic exercise and gait training

Exercise Control group

Eligibility Criteria

• Age: 55 Years - 90 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Male/Female 55-90 years old.
• Montreal Cognitive Assessment score ≤27
• Preserved Instrumental Activities of Daily Living (based on Lawton-Brody Instrumental Activities of Daily Living Sale)

You may not qualify if:

• Dementia (i.e., Mini-Mental Examination score \<24 or self-reported physician diagnosis)
• Major Depression (\>=16 on the Center for Epidemiologic Studies - Depression Scale combined with clinical judgment by primary study physician)
• Other neurological or psychiatric disorders
• Recent history of severe cardiovascular conditions
• Significant orthopedic conditions
• Have blood pressure \>180/100 mmHg or \<100/60 mmHg
• Unable to comprehend questionnaire material/study procedures

Sponsors & Collaborators

• Parkwood Hospital, London, Ontario: lead
• University of Western Ontario, Canada: collaborator
• Canadian Institutes of Health Research (CIHR): collaborator

Study Sites (1)

Aging, Rehabilitation and Geriatric Care Research Center

London, Ontario, N6C 5J1, Canada

Location

Related Publications (1)

• Gill DP, Gregory MA, Zou G, Liu-Ambrose T, Shigematsu R, Hachinski V, Fitzgerald C, Petrella RJ. The Healthy Mind, Healthy Mobility Trial: A Novel Exercise Program for Older Adults. Med Sci Sports Exerc. 2016 Feb;48(2):297-306. doi: 10.1249/MSS.0000000000000758.

  PMID: 26285025 DERIVED

MeSH Terms

Conditions

Cognitive Dysfunction

Interventions

Exercise

Condition Hierarchy (Ancestors)

Cognition Disorders; Neurocognitive Disorders; Mental Disorders

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Robert J Petrella, MD., PhD.

  London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: April 3, 2012
• First Posted: April 6, 2012
• Study Start: June 1, 2012
• Primary Completion: November 1, 2013
• Study Completion: May 1, 2014
• Last Updated: October 28, 2014

Record last verified: 2014-10

Locations

CA (1)