NCT01562808

Brief Summary

Dopamine receptor occupancy and brain metabolism were measured using positron emission tomography after the administration of aripiprazole. Working memory performance was also measured using N-back task. The investigators explored the relationship between changes in brain metabolism and working memory performance.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
15

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started Jan 2009

Typical duration for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 1, 2009

Completed
1.3 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

May 1, 2010

Completed
1.7 years until next milestone

Study Completion

Last participant's last visit for all outcomes

January 1, 2012

Completed
3 months until next milestone

First Submitted

Initial submission to the registry

March 22, 2012

Completed
4 days until next milestone

First Posted

Study publicly available on registry

March 26, 2012

Completed
Last Updated

March 26, 2012

Status Verified

March 1, 2012

Enrollment Period

1.3 years

First QC Date

March 22, 2012

Last Update Submit

March 23, 2012

Conditions

AntipsychoticsCognitionBrain MetabolismDopamine Receptor Occupancy

Outcome Measures

Primary Outcomes (1)

  • Reaction time of correct response in N-back task

    48 hrs after the administration of aripiprazole

Interventions

AripiprazoleDRUG

single oral administration of aripiprazole

Eligibility Criteria

Age19 Years - 30 Years
Sexmale
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • healthy volunteers
  • right-handed

You may not qualify if:

  • any significant abnormality on routine lab
  • any psychiatric disease

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Seoul National University Hospital

Seoul, 110-744, South Korea

Location

MeSH Terms

Interventions

Aripiprazole

Intervention Hierarchy (Ancestors)

PiperazinesHeterocyclic Compounds, 1-RingHeterocyclic CompoundsQuinolonesQuinolinesHeterocyclic Compounds, 2-RingHeterocyclic Compounds, Fused-Ring

Study Officials

  • Jun Soo Kwon, M.D., Ph.D.

    Seoul National University Hospital

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NA
Masking
SINGLE
Who Masked
PARTICIPANT
Purpose
BASIC SCIENCE
Intervention Model
SINGLE GROUP
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Professor

Study Record Dates

First Submitted

March 22, 2012

First Posted

March 26, 2012

Study Start

January 1, 2009

Primary Completion

May 1, 2010

Study Completion

January 1, 2012

Last Updated

March 26, 2012

Record last verified: 2012-03

Locations

KR(1)