Effect of the Intensity of Continuous Renal Replacement Therapy in Patients With Acute Kidney Injury
1 other identifier
interventional
211
1 country
1
Brief Summary
The current international Continuous Renal Replacement Therapy (CRRT) replacement fluid doses of 35 ml/kg/h is better, but the result is according to white people, black people . It is Whether the best amount of replacement fluid for Chinese people, it is unclear. Especially,there is little evidence about the optimal dose from randomized trials in Cardiac surgery associated acute kidney injury (CSA-AKI )required CRRT,According to the clinical situation, the design of replacement fluid to 25 ml/kg/h.The observation of two doses 14 days, 28 days, 90 days survival and renal function.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for phase_4
Started Mar 2011
Longer than P75 for phase_4
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
March 1, 2011
CompletedFirst Submitted
Initial submission to the registry
March 20, 2012
CompletedFirst Posted
Study publicly available on registry
March 22, 2012
CompletedPrimary Completion
Last participant's last visit for primary outcome
August 1, 2015
CompletedStudy Completion
Last participant's last visit for all outcomes
August 1, 2015
CompletedJanuary 20, 2016
January 1, 2016
4.4 years
March 20, 2012
January 17, 2016
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
death from any cause
The primary study outcome was death from any cause within 14, 28 ,90 and 365 days after randomization.
14, 28 ,90 and 365 days after randomization
Secondary Outcomes (1)
renal outcome of survivors
14, 28 ,90 and 365 days after randomization
Study Arms (2)
high dose (35ml/kg/h)
EXPERIMENTAL\> = 18 years of age, CRRT indications for acute kidney injury (RIFLE criteria) patients with cardiac surgery, was given filtration at a rate of 35 mL/kg/h.
low dose (25ml/kg/h)
EXPERIMENTAL\> = 18 years of age, CRRT indications for acute kidney injury (RIFLE criteria) patients with cardiac surgery, was given filtration at a rate of 25 mL/kg/h.
Interventions
Eligibility Criteria
You may qualify if:
- \> = 18 years of age, CRRT indications for acute kidney injury (RIFLE criteria) patients with cardiac surgery
You may not qualify if:
- \< 18 years old,
- with chronic kidney disease,
- dialysis history, to leave the ICU patients with acute kidney injury (AKI). - chronic kidney disease,
- all causes kidney damage (pathology, hematuria, and radiographic abnormalities)\> = 3 months or glomerular filtration rate \< 60ml/min for 3 months or more.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Wei Shilead
Study Sites (1)
Nephrology Department,Guangdong General Hospital
Guangzhou, Guangdong, China
Related Publications (1)
Fayad AI, Buamscha DG, Ciapponi A. Timing of kidney replacement therapy initiation for acute kidney injury. Cochrane Database Syst Rev. 2022 Nov 23;11(11):CD010612. doi: 10.1002/14651858.CD010612.pub3.
PMID: 36416787DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Wei Shi, MD, PhD
Guangdong Provincial People's Hospital
Study Design
- Study Type
- interventional
- Phase
- phase 4
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR INVESTIGATOR
- PI Title
- Director of renal division of Guangdong General Hospital
Study Record Dates
First Submitted
March 20, 2012
First Posted
March 22, 2012
Study Start
March 1, 2011
Primary Completion
August 1, 2015
Study Completion
August 1, 2015
Last Updated
January 20, 2016
Record last verified: 2016-01