An Observational Study of Avastin in First Line in Elderly Patients With Metastatic Colorectal Cancer (CASSIOPEE)
Non Interventional Study Evaluating Efficacy and Safety in a Cohort of Elderly Patients of First Line Therapy With Avastin ® Regimen for Metastatic Colorectal Cancer.
1 other identifier
observational
402
1 country
166
Brief Summary
This multicenter, prospective, observational study will evaluate the efficacy and safety of Avastin (bevacizumab) in first-line therapy in elderly patients with metastatic colorectal cancer. Data will be collected from eligible patients for24 months.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Mar 2012
Longer than P75 for all trials
166 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
March 5, 2012
CompletedFirst Submitted
Initial submission to the registry
March 14, 2012
CompletedFirst Posted
Study publicly available on registry
March 15, 2012
CompletedPrimary Completion
Last participant's last visit for primary outcome
July 20, 2016
CompletedStudy Completion
Last participant's last visit for all outcomes
July 20, 2016
CompletedResults Posted
Study results publicly available
January 22, 2019
CompletedMarch 5, 2019
February 1, 2019
4.4 years
March 14, 2012
September 28, 2017
February 8, 2019
Conditions
Outcome Measures
Primary Outcomes (1)
Progression-Free Survival
Progression was defined using Response Evaluation Criteria In Solid Tumors Criteria (RECIST v1.0), as a 20% increase in the sum of the longest diameter of target lesions, or a measurable increase in a non-target lesion, or the appearance of new lesions.
From the time of first dose of study treatment to the time of disease progression or death from any cause (Up to 53 months)
Secondary Outcomes (6)
Overall Survival
From the time of first dose of study treatment to the time of death from any cause (Up to 53 months)
Percentage of Participants With Bevacizumab Administration
Up to 36 months
Percentage of Participants With Adverse Events (AEs)
Up to 53 months
Percentage of Participants With Activities of Daily Living (ADL)
Baseline, Month 6, 12, 24
Lawton Instrumental Activities of Daily Living Score (IADL)
Baseline, Month 6, 12, 24
- +1 more secondary outcomes
Study Arms (1)
Cohort
Eligibility Criteria
Elderly patients with metastatic colorectal cancer initiating first-line treatment with Avastin
You may qualify if:
- Adult patients, \>/= 75 years of age
- Metastatic colorectal cancer
- Initiating Avastin first-line therapy in combination with chemotherapy
You may not qualify if:
- Previous Avastin therapy
- Patient participating in a clinical study evaluating a cytotoxic anti-cancer therapy and/or an investigational new drug
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (166)
Ch D Abbeville; Medecine B1
Abbeville, 80142, France
Clinique Du Docteur Calabet; Cromg
Agen, 47000, France
Ch D Agen; Medecine Interne II
Agen, 47923, France
C.H. Du Pays D'aix En Provence Service du Dr Blanc
Aix-en-Provence, 13616, France
Poly Parc Rambot La Provencale; Chimiotherapie Ambulatoire
Aix-en-Provence, 13617, France
Chd Castelluccio; Oncologie
Ajaccio, 20176, France
Clinique Claude Bernard; Onco Hematologie
Albi, 81030, France
Chi D Alencon; Medecine Ambulatoire
Alençon, 61014, France
Chi D Alencon; Medecine I
Alençon, 61014, France
Hopital Nord; Medecine A
Amiens, 80054, France
Clinique De L Europe; Pmsi
Amiens, 80090, France
Clinique De L Europe; Radiotherapie Chimiotherapie
Amiens, 80090, France
Centre Hospitalier de L'Agglomeration Montargeoise; Medecine Polyvalente A Orientation Mi & Cancero
Amilly, 45200, France
Cham; Medecine D
Amilly, 45200, France
Ctre Radiotherapie Et Onco Medic
Amilly, 45200, France
Hotel Dieu; Medecine A
Angers, 49093, France
Cabinet Medical
Arras, 62000, France
Centre Radiotherapie Marie Curie
Arras, 62000, France
Ch D Ardeche Meridionale; Medecine A2
Aubenas, 07205, France
Ch D Auch; Med Interne Chimiotherapie
Auch, 32008, France
Clinique Sainte Catherine; Hopital De Semaine
Avignon, 84918, France
Clinique Du Docteur Maymard; Hopital De Jour Chimiotherapie
Bastia, 20200, France
Hopital De Falconaja Furiani; Hopital De Jour
Bastia, 20604, France
Centre Hospitalier de La Cote Basque; Oncologie
Bayonne, 64109, France
Centre Hospitalier; Hematologie-Oncologie
Beauvais, 60021, France
Hopital Jean Minjoz; Gastro Enterologie
Besançon, 25030, France
Hopital Jean Minjoz; Hopital de Jour
Besançon, 25030, France
HOPITAL JEAN MINJOZ; Oncologie
Besançon, 25030, France
Clinique Anne D Artois; Gastro Enterologie
Béthune, 62404, France
Clinique Champeau Mediterranee; Radiotherapie Oncologie
Béziers, 34535, France
Hopital Avicenne; Cancerologie
Bobigny, 93009, France
Clinique Tivoli; Sce Radiotherapie
Bordeaux, 33000, France
Polyclin Bordeaux Nord Aquitaine; Gastro Enterologie
Bordeaux, 33077, France
Centre Hospitalier Dr Duchenne; Hepato Gastro Enterologie
Boulogne-sur-Mer, 62321, France
Clinique Du Docteur Convert; Medecine
Bourg-en-Bresse, 01004, France
Centre Hospitalier Fleyriat; Oncologie/Hematologie
Bourg-en-Bresse, 01012, France
Ch De Fleyriat; Gastro Enterologie
Bourg-en-Bresse, 01012, France
Hopital Augustin Morvan; Federation De Cancerologie
Brest, 29200, France
Clinique Pasteur Lanroze; Chimiotherapie Radiotherapie
Brest, 29220, France
CMC de Bligny; Hopital de Jour
Briis-sous-Forges, 91640, France
CMC de Bligny; Oncologie Court Sejour
Briis-sous-Forges, 91640, France
CMC de Bligny; Oncologie SSR
Briis-sous-Forges, 91640, France
Ch De Brive La Gaillarde; Radiotherapie Oncologie
Brive-la-Gaillarde, 19312, France
Hopital Cote De Nacre; Gastro Enterologie
Caen, 14033, France
Infirmerie Protestante; Endos Digestive Coelioscopie
Caluire-et-Cuire, 69300, France
Hopital Pierre Nouveau; Medecine A
Cannes, 06400, France
Ch Antoine Gayraud; Oncologie
Carcassonne, 11890, France
Clinique Montreal; Chimiotherapie
Carcassonne, France
Clinique Du Parc; Hematologie
Castelnau Lez, 34170, France
Cabinet Medical
Challes-les-Eaux, 73190, France
Medipole De Savoie; Departement Oncologie
Challes-les-Eaux, 73190, France
Oncologie 37; Bureau
Chambray-lès-Tours, 37170, France
Hopital Prive Paul d Egine; Chimiotherapie Ambulatoire
Champigny-sur-Marne, 94507, France
Centre Hospitalier; Oncologie
Châteauroux, 36019, France
Ch De Cholet; Gastro Enterologie
Cholet, 49325, France
Pole Sante Republique;Oncologie Hematologie
Clermont-Ferrand, 63050, France
Hopital Louis Pasteur; Medecine A
Colmar, 68024, France
Polyclinique Saint Come; Hopital De Jour Oncologie
Compiègne, 60204, France
CH Sud Francilien; Oncologie
Corbeil-Essonnes, 91100, France
Ch Laennec; Medecine V
Creil, 60109, France
CHU Henri Mondor; Service d'Oncologie Medicale
Créteil, 94010, France
Ch De Dax; Radiotherapie Oncologie
Dax, 40107, France
Centre Leonard De Vinci;Chimiotherapie
Dechy, 59187, France
Centre Georges Francois Leclerc; Oncologie 3
Dijon, 21079, France
Hopital Victor Jousselin; Gastro Enterologie
Druex, 28102, France
Centre D Oncologie Dunkerquois
Dunkirk, 59240, France
Chi Eure Seine D Evreux; Oncologie Conventionnelle
Évreux, 27015, France
Clinique Pasteur; Oncologie Medicale, Hematologie
Évreux, 27025, France
Ch Jacques Monod;Medecine A4 B4
Flers, 61104, France
Hopital De Freyming; Secteur 1
Freyming-Merlebach, 57804, France
Chi De Frejus Saint Raphael; Hopital De Jour
Fréjus, 83608, France
Chi Alpes Du Sud Site De Gap; Med Interne Et Polyvalente
Gap, 05000, France
Centre Gastro Loire
Gien, 45 500, France
Hopital Nord Ouest;Gastro Enterologie
Gleizé, 69400, France
CH Emmanuel Rain; Oncologie
Gonesse, 95503, France
Hopital Prive De Chantilly; Medecine
Gouvieux Chantilly, 60500, France
Hopital Alpha Sante De Hayange; Medecine B
Hayange, 57701, France
Clinique Sainte Marguerite; Oncologie Medicale
Hyères, 83400, France
Polyclinique de Blois; Chimiotherapie Ambulatoire
La Chaussée-Saint-Victor, 41260, France
Centre Hospitalier Departemental Les Oudairies
La Roche-sur-Yon, 85925, France
Centre Hospitalier Saint Louis; Oncologie Medicale
La Rochelle, 17019, France
Hopital Albert Michallon; Oncologie
La Tronche, 38700, France
Hopital Albert Michallon; Radiotherapie
La Tronche, 38700, France
Ch De Lagny Sur Marne; Oncologie
Lagny-sur-Marne, 77405, France
Hopital Robert Boulin; Oncologie
Libourne, 33505, France
Polyclinique Du Bois; Oncologie
Lille, 59003, France
Polyclinique De La Louviere; Chimiotherapie
Lille, 59042, France
Ch De Longjumeau; Hopital De Jour Et Semaine
Longjumeau, 91161, France
Clinique Des 4 Pavillons; Chimiotherapie
Lormont, 33310, France
Hopital De La Croix Rousse;Hepato Gastro Entero
Lyon, 69317, France
Ctre Consultations La Sauvegarde
Lyon, 69338, France
Ctre Hosp St Joseph Et St Luc; Gastro Enterologie Endoscopie
Lyon, 69365, France
Hopital Prive Jean Mermoz; Cancerologie
Lyon, 69373, France
Hopital Prive Jean Mermoz; Gastro Enterologie Hepatologie
Lyon, 69373, France
Clin Mut De Lyon Eugene Andre; Hopital De Jour 1er B
Lyon, 69424, France
Hopital Edouard Herriot; Pavillon E Oncologie Medicale
Lyon, 69437, France
Clinique Saint Francois; Oncologie Medicale
Mainvilliers, 28301, France
Clinique Mutualiste Bonneveine; Oncologie Medicale
Marseille, 13008, France
CH Prive Clairval; Chimiotherapie Ambulatoire
Marseille, 13274, France
Hôpital Saint Joseph; Oncologie Medicale
Marseille, 13285, France
Hopital Timone Adultes; Oncologie Digestive
Marseille, 13385, France
Clinique Du Parc; Centre de Radiotherapie Gray
Maubeuge, 59600, France
Hopital Clinique Claude Bernard; Oncologie Medicale
Metz, 57000, France
Chra; Gastro Enterologie
Metz-Tessy, 74370, France
Hopital Layne; Medecine A2
Mont-de-Marsan, 40024, France
Hopital Layne; Medecine Ambulatoire
Mont-de-Marsan, 40024, France
Ch De Montauban; Medecine Interne
Montauban, 82013, France
Site Le Mittan; Hopital De Jour
Montbéliard, 25209, France
Ch De Montelimar; Gastro Enterologie Oncologie
Montélimar, 26216, France
Ghi Le Raincy Montfermeil; Gastro Medecine Interne
Montfermeil, 93370, France
Ghi Le Raincy Montfermeil; Radiotherapie Oncologie
Montfermeil, 93370, France
Hopital Jacques Monod; Hopital De Semaine Unite 53
Montivilliers, 76290, France
Clinique Clementville; Hopital De Jour
Montpellier, 34070, France
Hopital Saint Eloi; Hopital De Jour
Montpellier, 34295, France
Polyclinique Saint Roch; Hop Jour Chimio Radiotherapie
Montpellier, 34967, France
Centre Azureen De Cancerologie; Cons externes
Mougins, 06250, France
Clinique D Occitanie; Chimiotherapie Ambulatoire
Muret, 31605, France
Centre D'Oncologie de Gentilly; Oncology
Nancy, 54100, France
Polyclinique Gentilly; CHIMIOTHERAPIE AMBULATOIRE
Nancy, 54100, France
Polyclinique Du Languedoc; Chimiotherapie
Narbonne, 11780, France
Hopital Americain; Sce Oncologie
Neuilly-sur-Seine, 92200, France
Ctre Radiotherapie Cyr Deguergue
Nevers, 58000, France
Centre Antoine Lacassagne; Hopital De Jour A2
Nice, 06189, France
Hopital Caremeau; Gastro Enterologie
Nîmes, 30029, France
Hopital Prive Armand Brillard; Groupe Sein Paris Est
Nogent-sur-Marne, 94130, France
Polyclinique Des Murlins;Ambulatoire
Orléans, 45000, France
Clinique sainte marie; chimiotherapie ambulatoire
Osny, 95520, France
Hopital Des Diaconesses; Oncologie
Paris, 75571, France
Hopital Saint Antoine; Oncologie Medicale
Paris, 75571, France
CH Pitie Salpetriere; Hepathologie Gastro Enterologie
Paris, 75651, France
GH Paris Saint Joseph; Hopital De Jour Oncologie
Paris, 75674, France
Hopital Bichat Claude Bernard; Hepatologie Gastro Enterologie
Paris, 75877, France
Hop Europeen Georges Pompidou; Gastro Enterologie
Paris, 75908, France
HOPITAL TENON; Cancerologie Medicale
Paris, 75970, France
Hopital Saint Jean; Hospitalisation Oncologie
Perpignan, 66046, France
Hopital Du Haut-Leveque; Gastro-Enterologie
Pessac, 33604, France
Clinique Francheville; Radiotherapie
Périgueux, 24000, France
Polyclinique Francheville; MED CHIMIOTHERAPIE RADIOTHERAPIE
Périgueux, 24000, France
Ch Lyon Sud; Chir Visc Sect Jules Courmont
Pierre-Bénite, 69495, France
Ch Lyon Sud; Gastro Secteur Jules Courmont
Pierre-Bénite, 69495, France
Ctre Hosp Des Vals D Ardeche; Medecine C
Privas, 07007, France
Ch De Rambouillet; Medecine A2
Rambouillet, 78514, France
Ch Arrondissement De Montreuil; Medecine 1
Rang-du-Fliers, 62180, France
Centre Frederic Joliot Curie
Rouen, 76000, France
Hopital Yves Le Foll; Hematologie Oncologie
Saint-Brieuc, 22027, France
Ctre De Radiotherapie St Vincent
Saint-Grégoire, 35768, France
Clinique de L'Union; Oncologie
Saint-Jean, 31240, France
Memorial France Etats Unis; Hopital De Jour
Saint-Lô, 50009, France
Centre Joliot Curie
Saint-Martin-Boulogne, 62280, France
Ch De Saint Quentin; Gastro Enterologie Endoscopie
Saint-Quentin, 02321, France
Ch De Selestat; Medecine A
Sélestat, 67604, France
Centre Clinical; Oncologie Medicale
Soyaux, 16800, France
Hopital Broussais; Medecine 2A
St-Malo, 35403, France
Clinique Chir De L Orangerie; Chimiotherapie
Strasbourg, 67010, France
Clinique Saint Anne; Hopital De Jour
Strasbourg, 67010, France
Fondation Maison Sante Bagatelle; Gastro Enterologie
Talence, 33401, France
Hopitaux Du Leman Site Thonon; Gastro Enterologie
Thonon-les-Bains, 74203, France
Clinique Pasteur; Oncologie Medicale
Toulouse, 31076, France
Hopital Joseph Ducuing; Medecine Interne
Toulouse, 31076, France
Hopital Prive Du Vert Galant; Cons Specialisees
Tremblay-en-France, 93290, France
Ch De Valence; Medecine 6
Valence, 26953, France
Clinique Oceane; Medecine B
Vannes, 56001, France
Hopital Saint Nicolas; Medecine A
Verdun, 55107, France
Clinique De La Porte Verte; EST 3
Versailles, 78004, France
Gh Mutualiste Les Portes Du Sud; Gastro-Enterologie
Vénissieux, 69200, France
Hopital Prive Villeneuve d Ascq;Chimiotherapie Radiotherapie
Villeneuve-d'Ascq, 59657, France
Related Publications (1)
Francois E, Mineur L, Deplanque G, Laplaige P, Smith D, Gourgou S, Tanang A, Ionescu-Goga M, Veerabudun K, Lelarge Y, Kim S, Rollot F. Efficacy and Safety of Bevacizumab Combined With First-Line Chemotherapy in Elderly (>/=75 Years) Patients With Metastatic Colorectal Cancer: A Real-World Study. Clin Colorectal Cancer. 2020 Sep;19(3):e100-e109. doi: 10.1016/j.clcc.2020.02.009. Epub 2020 Apr 13.
PMID: 32299778DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Results Point of Contact
- Title
- Medical Communications
- Organization
- Hoffmann-La Roche
Study Officials
- STUDY DIRECTOR
Clinical Trials
Hoffmann-La Roche
Publication Agreements
- PI is Sponsor Employee
- No
- Restriction Type
- OTHER
- Restrictive Agreement
- Yes
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- INDUSTRY
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
March 14, 2012
First Posted
March 15, 2012
Study Start
March 5, 2012
Primary Completion
July 20, 2016
Study Completion
July 20, 2016
Last Updated
March 5, 2019
Results First Posted
January 22, 2019
Record last verified: 2019-02