Schistosomiasis Effect on Response to Vaccines, Anaemia and Nutritional Status of Children of Northern Senegal

NCT01553552 | Completed DMC

• 1 other identifier: EPLS11-MS
• Study Type: observational
• Target: 99
• Locations: 1 country
• Sites: 1

Brief Summary

SchistoVAN aims to study the role of schistosomiasis infection in the modulation of the immune response of children to childhood vaccine antigens, as well as the impact of this infection on their nutritional status and their haemoglobinaemia.

Conditions

Schistosomiasis; Anemia; Underweight; Stunting; Intestinal Parasites

Keywords

Schistosoma haematobium; schistosoma mansoni; Anemia; Underweight; stunting; Blastocystis

Study Arms (2)

Infected by Schistosoma haematobium

Not infected by Schistosoma haematobium

Eligibility Criteria

• Age: 6 Years - 10 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17)
• Sampling Method: Non-Probability Sample

Study Population

Residents of 3 villages from the Senegal Valley River, belonging to the Podor District in Saint-Louis Region in Northern Senegal: Agniam Towguel, Fanaye Diery and Niandane. Subcohort of a previous study "AnoPalAnoVac" (ClinicalTrials.gov ID: NCT01545115)

You may qualify if:

• Members of AnoPalAnoVac cohort
• Age: between 6 and 10 years

You may not qualify if:

• body temperature \> 38.5 ºC
• malaria episode

Sponsors & Collaborators

• Biomedical Research Center EPLS: lead
• Institut Pasteur de Lille: collaborator
• University of Lille Nord de France: collaborator
• Région Nord-Pas de Calais, France: collaborator
• Centre d'Infection et d'Immunité de Lille: collaborator
• Centre National de la Recherche Scientifique, France: collaborator
• Institut National de la Santé Et de la Recherche Médicale, France: collaborator

Study Sites (1)

Biomedical Research Center EPLS

Saint-Louis, SL, Senegal

Location

Related Publications (1)

• Hermann E, Gaayeb L, Sow PS, Seck M, Sagna AB, Senghor S, Bandagny L, Brinkhuizen C, Delcroix-Genete D, Schacht AM, Riveau G. Sex-dependent interactions between leptin, wasting and humoral immunity in two ethnic communities of school-aged children differentially exposed to Schistosoma haematobium. Trans R Soc Trop Med Hyg. 2017 Oct 1;111(10):448-456. doi: 10.1093/trstmh/trx078.

  PMID: 29351649 DERIVED

Related Links

• EPLS website

Biospecimen

Retention: SAMPLES WITHOUT DNA

Whole blood Sera Urine Stool

MeSH Terms

Conditions

Schistosomiasis; Anemia; Thinness; Growth Disorders; Intestinal Diseases, Parasitic; Schistosomiasis haematobia

Condition Hierarchy (Ancestors)

Trematode Infections; Helminthiasis; Parasitic Diseases; Infections; Vector Borne Diseases; Hematologic Diseases; Hemic and Lymphatic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Pathologic Processes; Intestinal Diseases; Gastrointestinal Diseases; Digestive System Diseases; Urinary Tract Infections; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases

Study Officials

• Emmanuel Hermann, PhD A.Pr.

  Biomedical Research Center EPLS

  STUDY CHAIR

• Lobna Gaayeb, VetMed

  Biomedical Research Center EPLS

  STUDY DIRECTOR

• Modou Seck, MD

  Biomedical Research Center EPLS

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 12, 2012
• First Posted: March 14, 2012
• Study Start: October 1, 2011
• Primary Completion: October 1, 2011
• Study Completion: October 1, 2011
• Last Updated: March 14, 2012

Record last verified: 2012-03

Locations

SE (1)