NCT01553123

Brief Summary

The purpose of this study is to determine whether ulipristal acetate is effective in the treatment of females with anemia associated with uterine leiomyomas. The safety of this product will also be evaluated.

Trial Health

30
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Timeline
Completed

Started Apr 2012

Geographic Reach
1 country

47 active sites

Status
withdrawn

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

March 2, 2012

Completed
11 days until next milestone

First Posted

Study publicly available on registry

March 13, 2012

Completed
19 days until next milestone

Study Start

First participant enrolled

April 1, 2012

Completed
1.6 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

November 1, 2013

Completed
1 month until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2013

Completed
Last Updated

February 7, 2013

Status Verified

February 1, 2013

Enrollment Period

1.6 years

First QC Date

March 2, 2012

Last Update Submit

February 5, 2013

Conditions

Keywords

Leiomyomas

Outcome Measures

Primary Outcomes (1)

  • Change from baseline in hemoglobin levels (g/dL)

    Change from baseline in hemoglobin levels (g/dL)

    Day 1 of the first on-treatment menstrual cycle to the start, or scheduled start of menstrual cycle 3.

Study Arms (2)

Ulipristal with iron

EXPERIMENTAL
Drug: Ulipristal AcetateDrug: Iron

Placebo

PLACEBO COMPARATOR

Placebo with iron

Drug: Iron

Interventions

once daily, oral

Also known as: UPA
Ulipristal with iron
IronDRUG

once daily, dried ferrous sulfate

PlaceboUlipristal with iron

Eligibility Criteria

Age18 Years - 50 Years
Sexfemale
Healthy VolunteersNo
Age GroupsAdult (18-64)

You may qualify if:

  • Is a pre-menopausal female, 18 - 50 years;
  • Has documented leiomyoma(s);
  • Has leiomyoma-related anemia;
  • Has an endometrial biopsy within the screening period prior to the first dose of the test article which shows no endometrial hyperplasia;
  • Is willing and able to provide written informed consent and authorization to disclose protected health information.

You may not qualify if:

  • Has a history of uterine surgery that would interfere with the study;
  • Has a condition requiring immediate or intermittent blood transfusions;
  • Has a known coagulation disorder;
  • Has a history of uterine, cervix, ovarian, or breast cancer;
  • Has used a selective progesterone receptor modulator or a gonadotrophin releasing hormone agonist in previous 6 months;
  • Has received blood transfusion within 8 weeks before the screening visit;
  • Has abnormal liver functions;
  • Is pregnant.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (47)

Alabama Clinical Therapeutics

Birmingham, Alabama, 35235, United States

Location

Coastal Clinical Research, Inc

Mobile, Alabama, 36608, United States

Location

Women's Health Research

Phoenix, Arizona, 85015, United States

Location

Visions Clinical Research

Tucson, Arizona, 85712, United States

Location

Benchmark Research

Sacramento, California, 95816, United States

Location

Sharp Rees-Stealy Medical Group

San Diego, California, 92101, United States

Location

Medical Center for Clinical Research

San Diego, California, 92108, United States

Location

Downtown Women's Health Care

Denver, Colorado, 80218, United States

Location

Visions Clinical Research

Boynton Beach, Florida, 33472, United States

Location

Jacksonville Center for Clinical Research

Jacksonville, Florida, 32216, United States

Location

Altus Research

Lake Worth, Florida, 33461, United States

Location

Healthcare Clinical Data, Inc.

North Miami, Florida, 33161, United States

Location

All Women's Healthcare of West Broward

Plantation, Florida, 33324, United States

Location

Physician Care Clinical Research, LLC

Sarasota, Florida, 34321, United States

Location

Comprehensive Clinical Trials, LLC

West Palm Beach, Florida, 33409, United States

Location

Atlanta Women's Research Institute, Inc

Atlanta, Georgia, 30342, United States

Location

Mount Vernon Clinical Research, LLC

Sandy Springs, Georgia, 30328, United States

Location

Fellows Research Alliance

Savannah, Georgia, 31406, United States

Location

Women's Health Practice

Champaign, Illinois, 61820, United States

Location

Advanced Gynecologic Surgery Institute

Naperville, Illinois, 60540, United States

Location

Center for Women's Research

Palos Heights, Illinois, 60463, United States

Location

South Bend Clinical

Granger, Indiana, 46530, United States

Location

Praetorian Pharmaceutical Research, LLC

Marrero, Louisiana, 70072, United States

Location

Women Under Study, LLC

New Orleans, Louisiana, 70115, United States

Location

Hutzel Womens Health Specialists

Detroit, Michigan, 48201, United States

Location

Women's Clinic of Lincoln, P.C.

Lincoln, Nebraska, 68510, United States

Location

Office of Annette Mayes, MD, PC

Las Vegas, Nevada, 89106, United States

Location

Office of Edmond Pack, MD

Las Vegas, Nevada, 89106, United States

Location

Office of R. Garn Mabey, Jr

Las Vegas, Nevada, 89128, United States

Location

Lawrence Obstetrics-Gynecology Clinical Research

Lawrenceville, New Jersey, 08648, United States

Location

Southwest Clinical Research

Albuquerque, New Mexico, 87102, United States

Location

New York Center for Women's Health Research

New York, New York, 10038, United States

Location

Carolina Women's Research and Wellness Center

Durham, North Carolina, 27713, United States

Location

Physicians for Women of Greensboro

Greensboro, North Carolina, 27408, United States

Location

Eastern Carolina Women's Center

New Bern, North Carolina, 28562, United States

Location

Wake Research Associates

Raleigh, North Carolina, 27612, United States

Location

PMG Research of Wilmington

Wilmington, North Carolina, 28401, United States

Location

Hawthorne Medical Research

Winston-Salem, North Carolina, 27103, United States

Location

Columbus Center for Women's Health Research

Columbus, Ohio, 43213, United States

Location

Advanced Clinical Concepts

West Reading, Pennsylvania, 19611, United States

Location

Southeast Regional Research Group

Aiken, South Carolina, 29803, United States

Location

South Carolina Clinical Research Center, LLC

Columbia, South Carolina, 29201, United States

Location

Discovery Clinical Trials - Genesis Health Central Women's Care

Dallas, Texas, 75231, United States

Location

Advances in Health Inc

Houston, Texas, 77030, United States

Location

Willowbend Health and Wellness Associates

Plano, Texas, 75093, United States

Location

Clinical Trials of Texas Incorporated Laboratory

San Antonio, Texas, 78229, United States

Location

Riverside Regional Medical Center

Newport News, Virginia, 23601, United States

Location

MeSH Terms

Conditions

Leiomyoma

Interventions

ulipristal acetateIron

Condition Hierarchy (Ancestors)

Neoplasms, Muscle TissueNeoplasms, Connective and Soft TissueNeoplasms by Histologic TypeNeoplasms

Intervention Hierarchy (Ancestors)

Metals, HeavyElementsInorganic ChemicalsTransition ElementsMetals

Study Officials

  • Howard Zobrist, MS, PhD

    Watson Pharmaceuticals

    STUDY DIRECTOR
0

Study Design

Study Type
interventional
Phase
phase 3
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
PARTICIPANT, INVESTIGATOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

March 2, 2012

First Posted

March 13, 2012

Study Start

April 1, 2012

Primary Completion

November 1, 2013

Study Completion

December 1, 2013

Last Updated

February 7, 2013

Record last verified: 2013-02

Locations