Cooperative Lifestyle Programs (CLIP-II)
CLIP-II
2 other identifiers
interventional
249
1 country
3
Brief Summary
The aim is to study the effects of weight loss and weight loss combined with different types of physical activity on changes in physical functioning of older adults who are at-risk for cardiovascular disease.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable
Started Mar 2012
Longer than P75 for not_applicable
3 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
March 1, 2012
CompletedStudy Start
First participant enrolled
March 1, 2012
CompletedFirst Posted
Study publicly available on registry
March 7, 2012
CompletedPrimary Completion
Last participant's last visit for primary outcome
October 1, 2016
CompletedStudy Completion
Last participant's last visit for all outcomes
October 1, 2016
CompletedAugust 15, 2018
August 1, 2018
4.6 years
March 1, 2012
August 13, 2018
Conditions
Outcome Measures
Primary Outcomes (1)
400-M walk test and Lower Leg Strength
18 months
Secondary Outcomes (1)
CT Scan
November 2013-March 2017
Study Arms (3)
Weight Loss
ACTIVE COMPARATORCaloric restriction
Weight Loss and Aerobic Training
EXPERIMENTALCaloric restriction and walking
Weight Loss and Resistance Training
EXPERIMENTALCaloric restriction and lifting weights
Interventions
Caloric restriction
Eligibility Criteria
You may qualify if:
- Residence: community-dwelling men and women from the counties of interest (SR)
- Age: between 60-79 yrs (SR)
- Activity Status: sedentary (less than 60 minutes of moderate intensity structured physical activity each week and occurs in no less than 10 minute blocks; SR)
- Adiposity: obese as defined by a BMI ≥ 30 (OAC)
- Medical Criteria: documented evidence of an MI, PCTI, chronic stable angina, cardiovascular surgery (coronary artery or valvular heart disease) or an ATP III diagnosis of the metabolic syndrome (PCP)
- Mobility Disability: disability defined as self-reported difficulty with walking ¼ mile, climbing stairs, lifting and carrying groceries, or performing other household chores such as cleaning and yard work (SR)
- Stability of Residence: does not plan to move out of the county of residence for the duration of the study (SR)
- Agreeableness: willing and able to participate in all aspects of the trial (SR)
- Consents: willing to give an informed consent and sign a HIPAA authorization form (SR)
You may not qualify if:
- Severe Symptomatic Heart Disease: evidence of unstable angina, symptomatic congestive heart failure, or exercise induced complex ventricular arrhythmias (PCP)
- MI or cardiovascular procedure within the last 3-months (PCP)
- Blood Pressure: a resting blood pressure \> 160/100 mmHg (OAC)
- Severe Systemic Disease: diagnosis of Parkinson's disease, chronic liver disease (cirrhosis, chronic hepatitis, etc.), systemic rheumatic condition (rheumatoid arthritis, psoriatic arthritis, Reiter's disease, systemic lupus erythematosus, etc.), end stage renal disease or other systemic diseases or abnormal laboratory values which would preclude participants from safely participating in the protocol or impair their ability to complete the study (PCP)
- Cancer: active treatment for cancer other than non-melanotic skin cancer (PCP)
- Hearing or Sight Impairments: significant visual or hearing impairment that cannot be corrected and results in the inability to use the telephone or hear normal conversation (SR, OAC)
- Psychiatric Illness: bipolar depression or schizophrenia (defined as self-reported treatment for these conditions), currently receiving lithium or neuroleptics (PCP)
- Cognitive Impairment: dementia, delirium or impaired cognitive function as defined by a score on the Folstein Mini-Mental Status Exam \< 21 (OAC)
- Participation in Other Trials: currently participating in or planning to participate in another medical intervention study (SR)
- Alcohol Intake: consuming more than 21 alcoholic drinks per week or alcoholism (SR)
- Functional Limitations: unable to walk unassisted (SR, OAC)
- English Literacy: unable to speak or read English
- Clinical Center Staff Evaluation: judged to be unsuitable for the trial for any reason by the clinic staff. A participant can be excluded prior to randomization because of some unspecified health problem that has been identified that would put the patient at risk for adherence or retention. These cases are discussed with a recruitment team consisting of the person who has raised the concern, an MD, and the study PIs.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (3)
Kernersville YMCA.
Kernersville, North Carolina, 27284, United States
William G. White YMCA
Winston-Salem, North Carolina, 27101, United States
Fulton YMCA
Winston-Salem, North Carolina, 27105, United States
Related Publications (5)
Rejeski JJ, Fanning J, Nicklas BJ, Rejeski WJ. Six-month changes in ghrelin and glucagon-like peptide-1 with weight loss are unrelated to long-term weight regain in obese older adults. Int J Obes (Lond). 2021 Apr;45(4):888-894. doi: 10.1038/s41366-021-00754-0. Epub 2021 Feb 1.
PMID: 33526855DERIVEDRejeski WJ, Marsh AP, Fanning J, Ambrosius WT, Walkup MP, Nicklas BJ. Dietary Weight Loss, Exercise, and Inflammation in Older Adults with Overweight or Obesity and Cardiometabolic Disease. Obesity (Silver Spring). 2019 Nov;27(11):1805-1811. doi: 10.1002/oby.22600.
PMID: 31689007DERIVEDKammire DE, Walkup MP, Ambrosius WT, Lenchik L, Shapses SA, Nicklas BJ, Houston DK, Marsh AP, Rejeski WJ, Beavers KM. Effect of Weight Change Following Intentional Weight Loss on Bone Health in Older Adults with Obesity. Obesity (Silver Spring). 2019 Nov;27(11):1839-1845. doi: 10.1002/oby.22604. Epub 2019 Sep 4.
PMID: 31486297DERIVEDBeavers KM, Ambrosius WT, Rejeski WJ, Burdette JH, Walkup MP, Sheedy JL, Nesbit BA, Gaukstern JE, Nicklas BJ, Marsh AP. Effect of Exercise Type During Intentional Weight Loss on Body Composition in Older Adults with Obesity. Obesity (Silver Spring). 2017 Nov;25(11):1823-1829. doi: 10.1002/oby.21977.
PMID: 29086504DERIVEDMarsh AP, Janssen JA, Ambrosius WT, Burdette JH, Gaukstern JE, Morgan AR, Nesbit BA, Paolini JB, Sheedy JL, Rejeski WJ. The Cooperative Lifestyle Intervention Program-II (CLIP-II): design and methods. Contemp Clin Trials. 2013 Nov;36(2):382-93. doi: 10.1016/j.cct.2013.08.006. Epub 2013 Aug 23.
PMID: 23974035DERIVED
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
W. Jack Rejeski, PhD
Wake Forest University
- PRINCIPAL INVESTIGATOR
Anthony Marsh, PhD
Wake Forest University
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- OUTCOMES ASSESSOR
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
March 1, 2012
First Posted
March 7, 2012
Study Start
March 1, 2012
Primary Completion
October 1, 2016
Study Completion
October 1, 2016
Last Updated
August 15, 2018
Record last verified: 2018-08
Data Sharing
- IPD Sharing
- Will not share