NCT01545479

Brief Summary

It is well established that renal hypoxia is associated with the development of renal injury. The purpose of this study is measure the alterations in renal blood oxygenation after angiotensin II converting enzyme inhibition. The understanding of kidney adaptive mechanisms to renin angiotensin system effects in healthy subjects will be useful for the early detection of renal disease and for the development of new therapies to decrease the progression of the disease and its consequences.

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
5

participants targeted

Target at below P25 for phase_4

Timeline
Completed

Started Jan 2010

Shorter than P25 for phase_4

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 1, 2010

Completed
9 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

October 1, 2010

Completed
2 months until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2010

Completed
1.1 years until next milestone

First Submitted

Initial submission to the registry

January 16, 2012

Completed
2 months until next milestone

First Posted

Study publicly available on registry

March 6, 2012

Completed
Last Updated

March 6, 2012

Status Verified

March 1, 2012

Enrollment Period

9 months

First QC Date

January 16, 2012

Last Update Submit

March 1, 2012

Conditions

Renal Disease

Keywords

ECABOLD-MRIkidney

Outcome Measures

Primary Outcomes (1)

  • Measure the renal blood oxigenation after angiotensin converting enzyme inhibition

    up to 12 months

Study Arms (1)

Captopril 25mg

OTHER

To study the renal blood oxygenation, the subjects took captopril (25mg).

Drug: captopril 25mg

Interventions

captopril 25mgDRUG

renal blood oxygenation after captopril

Also known as: BOLD-MRI
Captopril 25mg

Eligibility Criteria

Age45 Years - 55 Years
Sexfemale
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • healthy female between 45 and 55 years

You may not qualify if:

  • man and
  • health female below 45 and above 55 years

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Related Publications (1)

  • Stein A, Goldmeier S, Voltolini S, Setogutti E, Feldman C, Figueiredo E, Eick R, Irigoyen M, Rigatto K. Renal oxygen content is increased in healthy subjects after angiotensin-converting enzyme inhibition. Clinics (Sao Paulo). 2012 Jul;67(7):761-5. doi: 10.6061/clinics/2012(07)10.

    PMID: 22892920DERIVED

MeSH Terms

Conditions

Kidney Diseases

Interventions

Captopril

Condition Hierarchy (Ancestors)

Urologic DiseasesFemale Urogenital DiseasesFemale Urogenital Diseases and Pregnancy ComplicationsUrogenital DiseasesMale Urogenital Diseases

Intervention Hierarchy (Ancestors)

ProlineImino AcidsAmino Acids, CyclicAmino AcidsAmino Acids, Peptides, and Proteins

Study Officials

  • MAntonieta Moraes, Dr

    Instituto de Cardiologia do Rio Grande do Sul

    STUDY CHAIR

Study Design

Study Type
interventional
Phase
phase 4
Allocation
NA
Masking
NONE
Purpose
HEALTH SERVICES RESEARCH
Intervention Model
SINGLE GROUP
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Doctorate

Study Record Dates

First Submitted

January 16, 2012

First Posted

March 6, 2012

Study Start

January 1, 2010

Primary Completion

October 1, 2010

Study Completion

December 1, 2010

Last Updated

March 6, 2012

Record last verified: 2012-03