NCT01543178

Brief Summary

This study will evaluate the effectiveness and safety of repeat treatment with rifaximin 550 mg three times a day in patients with IBS with diarrhea who respond to initial treatment of rifaximin 550 mg three times a day.

Trial Health

90
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
2,583

participants targeted

Target at P75+ for phase_3

Timeline
Completed

Started Feb 2012

Geographic Reach
3 countries

296 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

February 1, 2012

Completed
26 days until next milestone

First Submitted

Initial submission to the registry

February 27, 2012

Completed
4 days until next milestone

First Posted

Study publicly available on registry

March 2, 2012

Completed
2.2 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 1, 2014

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

June 1, 2014

Completed
1.1 years until next milestone

Results Posted

Study results publicly available

July 8, 2015

Completed
Last Updated

December 12, 2017

Status Verified

December 1, 2017

Enrollment Period

2.3 years

First QC Date

February 27, 2012

Results QC Date

June 15, 2015

Last Update Submit

December 8, 2017

Conditions

Keywords

IBSIBS-DIBS with diarrheaDiarrheaIrritable bowel syndrome with diarrhea

Outcome Measures

Primary Outcomes (1)

  • Repeat Treatment Responders

    Subjects who respond to repeat treatment in both IBS-related abdominal pain and stool consistency. The proportion of patients who responded to repeat treatment during the first double-blind repeat treatment phase is presented. Response is defined as improvement from baseline in abdominal pain AND reduction from baseline in diarrhea.

    4-week treatment-free follow-up in double-blind repeat treatment phase.

Study Arms (3)

Rifaximin open-label

EXPERIMENTAL

Subjects will receive open-label rifaximin 550 mg TID for 2 weeks with a 4-week treatment-free follow-up. Responders will continue into Maintenance Phase 1 (treatment free). Nonresponders will withdraw from the study. Subjects who meet criteria for recurrence in Maintenance Phase 1 enter the double-blind period and are randomized 1:1 to receive rifaximin 550 mg or placebo.

Drug: open-label rifaximin

Double-blind rifaximin (retreatment)

EXPERIMENTAL

Subjects in this arm receive rifaximin 550 mg TID for 2 weeks with a 4-week treatment-free follow-up (first retreatment) followed by Maintenance Phase 2 (6 weeks \[treatment free\]) followed by a second retreatment with rifaximin 550 mg TID for 2 weeks with a 4-week treatment-free follow-up.

Drug: open-label rifaximinDrug: double-blind rifaximin

Double-blind placebo (retreatment)

PLACEBO COMPARATOR

Subjects in this arm receive placebo TID for 2 weeks with a 4-week treatment-free follow-up (first retreatment) followed by Maintenance Phase 2 (6 weeks \[treatment free\]) followed by a second retreatment with placebo TID for 2 weeks with a 4-week treatment-free follow-up.

Drug: open-label rifaximinDrug: double-blind placebo

Interventions

550 mg three times a day (open-label)

Also known as: rifaximin
Double-blind placebo (retreatment)Double-blind rifaximin (retreatment)Rifaximin open-label

3 times a day (double-blind)

Also known as: Placebo
Double-blind placebo (retreatment)

550 mg three times a day (double-blind)

Also known as: rifaximin
Double-blind rifaximin (retreatment)

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • IBS confirmed by Rome III diagnostic criteria.
  • At least 18 years of age.
  • Colonoscopy within the past 10 years to rule out inflammatory bowel disease; or flexible sigmoidoscopy if \< 50 years of age or previous colonoscopy \> 10 years prior.
  • Willing to maintain a stable diet. including vitamins, supplements, and nutraceuticals.

You may not qualify if:

  • Diabetes (Type 1 or 2).
  • Lactose intolerance and not controlled by a lactose-free diet.
  • Pregnant or planning to become pregnant or is lactating.
  • History of HIV or hepatitis B or C.
  • Participation in investigational study within past 30 days.
  • Taking rifaximin or any other antibiotic within past 60 days.
  • Unstable cardiovascular or pulmonary disease, with change in treatment in last 30 days due to worsening disease condition.
  • History of GI surgery.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (296)

Unknown Facility

Anniston, Alabama, 36207, United States

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Birmingham, Alabama, 35216, United States

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Birmingham, Alabama, 35235, United States

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Birmingham, Alabama, 35243, United States

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Birmingham, Alabama, 35405, United States

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Dothan, Alabama, 36305, United States

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Huntsville, Alabama, 35801, United States

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Montgomery, Alabama, 36104, United States

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Montgomery, Alabama, 36109, United States

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Selma, Alabama, 37601, United States

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Chandler, Arizona, 85224, United States

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Peoria, Arizona, 85381, United States

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Phoenix, Arizona, 85018, United States

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Scottsdale, Arizona, 85257, United States

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Tempe, Arizona, 85282, United States

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Tucson, Arizona, 85704, United States

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Tucson, Arizona, 85710, United States

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Tucson, Arizona, 85712, United States

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Jonesboro, Arkansas, 82401, United States

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Little Rock, Arkansas, 72204, United States

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Little Rock, Arkansas, 72205, United States

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Little Rock, Arkansas, 72212, United States

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North Little Rock, Arkansas, 72117, United States

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Sherwood, Arkansas, 72120, United States

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Anaheim, California, 92801, United States

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Artesia, California, 90701, United States

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Carlsbad, California, 92008, United States

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Chula Vista, California, 91910, United States

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Chula Vista, California, 91911, United States

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Concord, California, 94520, United States

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Encinitas, California, 92024, United States

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Encino, California, 91436, United States

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Escondido, California, 92025, United States

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Garden Grove, California, 92840, United States

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Garden Grove, California, 92844, United States

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Garden Grove, California, 92845, United States

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Glendale, California, 91204, United States

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Huntington Beach, California, 92647, United States

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La Mesa, California, 91942, United States

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La Mirada, California, 90638, United States

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Laguna Hills, California, 92653, United States

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Lakewood, California, 90712, United States

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Lincoln, California, 95648, United States

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Lomita, California, 90717, United States

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Long Beach, California, 90806, United States

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Long Beach, California, 90813, United States

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Los Angeles, California, 90036, United States

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Los Angeles, California, 90045, United States

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Los Angeles, California, 90048, United States

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Madera, California, 93619, United States

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Mill Valley, California, 94941, United States

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Montebello, California, 90640, United States

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North Hollywood, California, 91606, United States

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Orange, California, 92868, United States

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Redlands, California, 92374, United States

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Sacramento, California, 95821, United States

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San Carlos, California, 94070, United States

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San Diego, California, 92101, United States

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San Diego, California, 92108, United States

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San Diego, California, 92114, United States

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San Diego, California, 92123, United States

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Vista, California, 92083, United States

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Colorado Springs, Colorado, 80920, United States

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Colorado Springs, Colorado, 90807, United States

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Denver, Colorado, 80211, United States

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Denver, Colorado, 80220, United States

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Lakewood, Colorado, 80215, United States

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Lone Tree, Colorado, 80124, United States

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Bridgeport, Connecticut, 06606, United States

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Bristol, Connecticut, 06010, United States

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Danbury, Connecticut, 06810, United States

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Torrington, Connecticut, 06790, United States

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Boca Raton, Florida, 33428, United States

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Boca Raton, Florida, 33432, United States

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Boynton Beach, Florida, 33426, United States

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Boynton Beach, Florida, 33472, United States

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Brandon, Florida, 33511, United States

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Clearwater, Florida, 33756, United States

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Gainesville, Florida, 32607, United States

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Hialeah, Florida, 33010, United States

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Hialeah, Florida, 33012, United States

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Hialeah, Florida, 33016, United States

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Hollywood, Florida, 33021, United States

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Jupiter, Florida, 33458, United States

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Kissimmee, Florida, 34741, United States

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Lake Worth, Florida, 33449, United States

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Largo, Florida, 33777, United States

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Lauderdale Lakes, Florida, 33319, United States

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Maitland, Florida, 32751, United States

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Miami, Florida, 33015, United States

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Miami, Florida, 33136, United States

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Miami, Florida, 33143, United States

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Miami, Florida, 33144, United States

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Miami, Florida, 33155, United States

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Miami, Florida, 33156, United States

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Miami, Florida, 33165, United States

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Miami, Florida, 33174, United States

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Miami Springs, Florida, 33166, United States

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Naples, Florida, 34102, United States

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Orange Park, Florida, 32073, United States

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Orlando, Florida, 32806, United States

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Ormond Beach, Florida, 32174, United States

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Plant City, Florida, 33563, United States

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Pompano Beach, Florida, 33060, United States

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Port Orange, Florida, 32127, United States

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Sarasota, Florida, 34231, United States

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Seminole, Florida, 33777, United States

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St. Petersburg, Florida, 33709, United States

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Tampa, Florida, 33603, United States

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Tampa, Florida, 33613, United States

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Wellington, Florida, 33414, United States

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West Palm Beach, Florida, 33406, United States

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West Palm Beach, Florida, 33409, United States

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Winter Haven, Florida, 33880, United States

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Winter Park, Florida, 32789, United States

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Zephyrhills, Florida, 33542, United States

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Athens, Georgia, 30606, United States

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Atlanta, Georgia, 30338, United States

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Atlanta, Georgia, 30342, United States

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Augusta, Georgia, 30909, United States

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Augusta, Georgia, 30912, United States

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Columbus, Georgia, 31904, United States

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Columbus, Georgia, 31909, United States

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Macon, Georgia, 31201, United States

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Marietta, Georgia, 30060, United States

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Norcross, Georgia, 30092, United States

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Boise, Idaho, 83642, United States

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Boise, Idaho, 83709, United States

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Hayden Lake, Idaho, 83835, United States

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Idaho Falls, Idaho, 83406, United States

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Arlington Heights, Illinois, 60005, United States

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Chicago, Illinois, 60602, United States

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Evanston, Illinois, 60201, United States

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Oak Lawn, Illinois, 60453, United States

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Elkhart, Indiana, 46514, United States

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Evansville, Indiana, 47713, United States

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Evansville, Indiana, 47714, United States

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Indianapolis, Indiana, 46202, United States

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Mishawaka, Indiana, 46545, United States

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Clive, Iowa, 50325, United States

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Iowa City, Iowa, 52242, United States

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Kansas City, Kansas, 66160, United States

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Overland Park, Kansas, 66215, United States

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Topeka, Kansas, 66604, United States

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Wichita, Kansas, 67226, United States

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Bowling Green, Kentucky, 42101, United States

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Crestview Hills, Kentucky, 41017, United States

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Hebron, Kentucky, 41048, United States

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Lexington, Kentucky, 40504, United States

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Lexington, Kentucky, 40509, United States

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Louisville, Kentucky, 40291, United States

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Madisonville, Kentucky, 42431, United States

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Metairie, Louisiana, 70006, United States

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New Orleans, Louisiana, 70115, United States

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Shreveport, Louisiana, 71103, United States

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Annapolis, Maryland, 21401, United States

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Baltimore, Maryland, 21215, United States

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Baltimore, Maryland, 21229, United States

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Hagerstown, Maryland, 21742, United States

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Hollywood, Maryland, 20636, United States

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Boston, Massachusetts, 02135, United States

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Brockton, Massachusetts, 02302, United States

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Marlborough, Massachusetts, 01752, United States

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Watertown, Massachusetts, 02472, United States

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Ann Arbor, Michigan, 48109, United States

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Kalamazoo, Michigan, 49008, United States

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Kalamazoo, Michigan, 49009, United States

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Saginaw, Michigan, 48604, United States

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Wyoming, Michigan, 49519, United States

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Jackson, Mississippi, 39202, United States

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Ocean Springs, Mississippi, 39564, United States

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Kansas City, Missouri, 64114, United States

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Lee's Summit, Missouri, 64064, United States

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Mexico, Missouri, 65265, United States

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St Louis, Missouri, 63104, United States

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St Louis, Missouri, 63122, United States

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St Louis, Missouri, 63141, United States

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Missoula, Montana, 59808, United States

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Bellevue, Nebraska, 68005, United States

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Fremont, Nebraska, 68025, United States

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Omaha, Nebraska, 68130, United States

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Henderson, Nevada, 89052, United States

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Las Vegas, Nevada, 89109, United States

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Las Vegas, Nevada, 89128, United States

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Reno, Nevada, 89511, United States

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Lebanon, New Hampshire, 05756, United States

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Newington, New Hampshire, 03801, United States

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Haddon Heights, New Jersey, 08030, United States

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Marlton, New Jersey, 08053, United States

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Albuquerque, New Mexico, 87102, United States

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Unknown Facility

Albuquerque, New Mexico, 87108, United States

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Brooklyn, New York, 11206, United States

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Great Neck, New York, 11021, United States

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Unknown Facility

Great Neck, New York, 11023, United States

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Hollis, New York, 11423, United States

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Mineola, New York, 39202, United States

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New York, New York, 10075, United States

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Poughkeepsie, New York, 12601, United States

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Rochester, New York, 14609, United States

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Asheboro, North Carolina, 27203, United States

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Asheville, North Carolina, 28801, United States

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Boone, North Carolina, 28607, United States

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Cary, North Carolina, 27518, United States

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Chapel Hill, North Carolina, 27599, United States

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Charlotte, North Carolina, 28207, United States

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Unknown Facility

Greensboro, North Carolina, 27403, United States

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Greensboro, North Carolina, 27408, United States

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High Point, North Carolina, 27262, United States

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Kinston, North Carolina, 28501, United States

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Raleigh, North Carolina, 27613, United States

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Salisbury, North Carolina, 28144, United States

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Wilmington, North Carolina, 28479, United States

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Winston-Salem, North Carolina, 27103, United States

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Fargo, North Dakota, 85103, United States

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Akron, Ohio, 44302, United States

Location

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Akron, Ohio, 44311, United States

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Centerville, Ohio, 45459, United States

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Cincinnati, Ohio, 45219, United States

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Cincinnati, Ohio, 45242, United States

Location

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Cleveland, Ohio, 44115, United States

Location

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Columbus, Ohio, 43214, United States

Location

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Columbus, Ohio, 43215, United States

Location

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Dayton, Ohio, 45415, United States

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Dayton, Ohio, 45432, United States

Location

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Groveport, Ohio, 43215, United States

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Kettering, Ohio, 45429, United States

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Mentor, Ohio, 44060, United States

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Norman, Oklahoma, 73069, United States

Location

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Oklahoma City, Oklahoma, 73103, United States

Location

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Oklahoma City, Oklahoma, 73120, United States

Location

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Tulsa, Oklahoma, 74104, United States

Location

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Tulsa, Oklahoma, 74136, United States

Location

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Medford, Oregon, 97504, United States

Location

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Portland, Oregon, 97210, United States

Location

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Downingtown, Pennsylvania, 19335, United States

Location

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Pittsburgh, Pennsylvania, 15206, United States

Location

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Reading, Pennsylvania, 19606, United States

Location

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Sayre, Pennsylvania, 18840, United States

Location

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East Providence, Rhode Island, 02914, United States

Location

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Warwick, Rhode Island, 02886, United States

Location

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Charleston, South Carolina, 29407, United States

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Charleston, South Carolina, 29412, United States

Location

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Columbia, South Carolina, 29203, United States

Location

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Fort Mill, South Carolina, 29707, United States

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Gaffney, South Carolina, 29341, United States

Location

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Greer, South Carolina, 29650, United States

Location

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Brentwood, Tennessee, 37027, United States

Location

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Bristol, Tennessee, 37620, United States

Location

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Chattanooga, Tennessee, 37421, United States

Location

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Franklin, Tennessee, 37067, United States

Location

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Germantown, Tennessee, 38138, United States

Location

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Hermitage, Tennessee, 37076, United States

Location

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Kingsport, Tennessee, 37660, United States

Location

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Nashville, Tennessee, 37205, United States

Location

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Arlington, Texas, 76012, United States

Location

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Austin, Texas, 78705, United States

Location

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Austin, Texas, 78731, United States

Location

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Austin, Texas, 78735, United States

Location

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Austin, Texas, 78745, United States

Location

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Corsicana, Texas, 75110, United States

Location

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Dallas, Texas, 75224, United States

Location

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El Paso, Texas, 79905, United States

Location

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Houston, Texas, 77005, United States

Location

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Houston, Texas, 77011, United States

Location

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Houston, Texas, 77030, United States

Location

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Houston, Texas, 77074, United States

Location

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Houston, Texas, 77090, United States

Location

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Houston, Texas, 77098, United States

Location

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Lake Jackson, Texas, 77566, United States

Location

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Odessa, Texas, 79761, United States

Location

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Pasadena, Texas, 77505, United States

Location

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Plano, Texas, 75075, United States

Location

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San Antonio, Texas, 78215, United States

Location

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San Antonio, Texas, 78229, United States

Location

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San Antonio, Texas, 78258, United States

Location

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Sealy, Texas, 77474, United States

Location

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Southlake, Texas, 76092, United States

Location

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Tyler, Texas, 75701, United States

Location

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Bountiful, Utah, 84010, United States

Location

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Ogden, Utah, 84405, United States

Location

Unknown Facility

Salt Lake City, Utah, 84107, United States

Location

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West Jordan, Utah, 84088, United States

Location

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Charlottesville, Virginia, 22911, United States

Location

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Chesapeake, Virginia, 23320, United States

Location

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Danville, Virginia, 24541, United States

Location

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Fairfax, Virginia, 22031, United States

Location

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Richmond, Virginia, 23225, United States

Location

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Suffolk, Virginia, 23434, United States

Location

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Bellevue, Washington, 98004, United States

Location

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Seattle, Washington, 98105, United States

Location

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Spokane, Washington, 99208, United States

Location

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Milwaukee, Wisconsin, 53215, United States

Location

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Milwaukee, Wisconsin, 53226, United States

Location

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Berlin, 14193, Germany

Location

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Hamburg, 22297, Germany

Location

Unknown Facility

Manchester, M23 9LT, United Kingdom

Location

Related Publications (6)

  • Lacy BE, Chang L, Rao SSC, Heimanson Z, Sayuk GS. Rifaximin Treatment for Individual and Multiple Symptoms of Irritable Bowel Syndrome With Diarrhea: An Analysis Using New End Points. Clin Ther. 2023 Mar;45(3):198-209. doi: 10.1016/j.clinthera.2023.01.010. Epub 2023 Mar 14.

  • Fodor AA, Pimentel M, Chey WD, Lembo A, Golden PL, Israel RJ, Carroll IM. Rifaximin is associated with modest, transient decreases in multiple taxa in the gut microbiota of patients with diarrhoea-predominant irritable bowel syndrome. Gut Microbes. 2019;10(1):22-33. doi: 10.1080/19490976.2018.1460013. Epub 2018 Jul 18.

  • Cash BD, Pimentel M, Rao SSC, Weinstock L, Chang L, Heimanson Z, Lembo A. Repeat treatment with rifaximin improves irritable bowel syndrome-related quality of life: a secondary analysis of a randomized, double-blind, placebo-controlled trial. Therap Adv Gastroenterol. 2017 Sep;10(9):689-699. doi: 10.1177/1756283X17726087. Epub 2017 Sep 11.

  • Pimentel M, Cash BD, Lembo A, Wolf RA, Israel RJ, Schoenfeld P. Repeat Rifaximin for Irritable Bowel Syndrome: No Clinically Significant Changes in Stool Microbial Antibiotic Sensitivity. Dig Dis Sci. 2017 Sep;62(9):2455-2463. doi: 10.1007/s10620-017-4598-7. Epub 2017 Jun 6.

  • DuPont HL, Wolf RA, Israel RJ, Pimentel M. Antimicrobial Susceptibility of Staphylococcus Isolates from the Skin of Patients with Diarrhea-Predominant Irritable Bowel Syndrome Treated with Repeat Courses of Rifaximin. Antimicrob Agents Chemother. 2016 Dec 27;61(1):e02165-16. doi: 10.1128/AAC.02165-16. Print 2017 Jan. No abstract available.

  • Lembo A, Pimentel M, Rao SS, Schoenfeld P, Cash B, Weinstock LB, Paterson C, Bortey E, Forbes WP. Repeat Treatment With Rifaximin Is Safe and Effective in Patients With Diarrhea-Predominant Irritable Bowel Syndrome. Gastroenterology. 2016 Dec;151(6):1113-1121. doi: 10.1053/j.gastro.2016.08.003. Epub 2016 Aug 13.

MeSH Terms

Conditions

Diarrhea

Interventions

Rifaximin

Condition Hierarchy (Ancestors)

Signs and Symptoms, DigestiveSigns and SymptomsPathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

RifamycinsHeterocyclic Compounds, 4 or More RingsHeterocyclic Compounds, Fused-RingHeterocyclic CompoundsLactams, MacrocyclicMacrocyclic CompoundsPolycyclic Compounds

Results Point of Contact

Title
David Sorscher
Organization
Salix

Study Officials

  • Enoch Bortey, PhD

    Bausch Health Americas, Inc.

    STUDY DIRECTOR

Publication Agreements

PI is Sponsor Employee
No
Restriction Type
GT60
Restrictive Agreement
Yes

Study Design

Study Type
interventional
Phase
phase 3
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
PARTICIPANT, INVESTIGATOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

February 27, 2012

First Posted

March 2, 2012

Study Start

February 1, 2012

Primary Completion

June 1, 2014

Study Completion

June 1, 2014

Last Updated

December 12, 2017

Results First Posted

July 8, 2015

Record last verified: 2017-12

Locations